Central retinal artery occlusion as a result of symptomatic patent foramen ovale
Rom J Ophthalmol. 2023 Jan-Mar;67(1):69-72. doi: 10.22336/rjo.2023.12. ABSTRACT Objective: The objective of this case report is to highlight the importance of patent foramen ovale (PFO) as a potential cause of central retinal artery occlusion (CRAO). Methods: A teenage girl presented with a sudden painless onset of vision loss in the right eye, which was accompanied […]
Hyperglycemia induces tear reduction and dry eye in diabetic mice through the norepinephrine-α1AR -mitochondrial impairment axis of lacrimal gland
Am J Pathol. 2023 Apr 21:S0002-9440(23)00132-3. doi: 10.1016/j.ajpath.2023.03.015. Online ahead of print. ABSTRACT Dry eye syndrome is a common complication in diabetic patients with a prevalence of up to 54.3%. However, the pathogenic mechanisms underlying hyperglycemia-induced tear reduction and dry eye remain less understood. In the present study, we found that both norepinephrine (NE) and […]
Watching the human retina breath in real time and the slowing of mitochondrial respiration with age
Sci Rep. 2023 Apr 20;13(1):6445. doi: 10.1038/s41598-023-32897-7. ABSTRACT The retina has the greatest metabolic demand in the body particularly in dark adaptation when its sensitivity is enhanced. This requires elevated level of perfusion to sustain mitochondrial activity. However, mitochondrial performance declines with age leading to reduced adaptive ability. We assessed human retina metabolism in vivo […]
Therapeutic possibilities of stimulating reparative neurogenesis in patients with glaucoma who have recovered from a coronavirus infection
Vestn Oftalmol. 2023;139(2):44-51. doi: 10.17116/oftalma202313902144. ABSTRACT In patients with glaucoma, the neuroplasticity of retinal cells, their axons and neuroglial elements is pathogenetically reduced, including due to a decrease in the concentration of neurotrophic factors. Coronavirus infections contribute to the damage processes, causing apoptosis of retinal and optic nerve cells. In this regard, the possibility of […]
Comparison of different gene-therapy methods to treat Leber hereditary optic neuropathy in a mouse model
Front Neurosci. 2023 Mar 27;17:1119724. doi: 10.3389/fnins.2023.1119724. eCollection 2023. ABSTRACT INTRODUCTION: Therapies for Leber hereditary optic neuropathy (LHON), in common with all disorders caused by mutated mitochondrial DNA, are inadequate. We have developed two gene therapy strategies for the disease: mitochondrial-targeted and allotopic expressed and compared them in a mouse model of LHON. METHODS: A […]
The Pathological Mechanisms and Novel Therapeutics for Leber’s Hereditary Optic Neuropathy
J Chin Med Assoc. 2023 Apr 10. doi: 10.1097/JCMA.0000000000000927. Online ahead of print. ABSTRACT Optic neuropathies were estimated to affect 115 in 100,000 population in 2018. Leber’s Hereditary Optic Neuropathy (LHON) as one of such optic neuropathy diseases that was first identified in 1871 and can be defined as a hereditary mitochondrial disease. LHON is […]
Wolfberry water extract attenuates blue light-emitting diode damage to ARPE-19 cells and mouse retina by activating the NRF2 signaling pathway
J Food Sci. 2023 Apr 6. doi: 10.1111/1750-3841.16559. Online ahead of print. ABSTRACT The wolfberry is believed to improve eyesight in traditional Chinese medicine. Soaking wolfberry in thermos cups has become a common health-preserving practice. The object of this paper was to research the protective effects of wolfberry water extract (WWE) on oxidative injury induced […]
Nonsyndromic Retinitis Pigmentosa Overview
2000 Aug 4 [updated 2023 Mar 30]. In: Adam MP, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2023. ABSTRACT The goals of this overview on nonsyndromic retinitis pigmentosa are the following. GOAL 1: Describe the clinical characteristics of nonsyndromic retinitis pigmentosa. […]
Ocular Stress Enhances Contralateral Transfer of Lenadogene Nolparvovec Gene Therapy through Astrocyte Networks
Mol Ther. 2023 Apr 3:S1525-0016(23)00195-8. doi: 10.1016/j.ymthe.2023.03.035. Online ahead of print. ABSTRACT Lenadogene nolparvovec (GS010) was developed to treat a point mutation in mitochondrial ND4 that causes Leber hereditary optic neuropathy. Lenadogene nolparvovec delivers human cDNA encoding wild-type ND4 packaged into an rAAV2/2 vector that transduces retinal ganglion cells, to induce allotopic expression of hybrid […]
SRT1720 attenuates UVA-induced corneal endothelial damage via inhibition of oxidative stress and cellular apoptosis
Exp Eye Res. 2023 Apr 2:109464. doi: 10.1016/j.exer.2023.109464. Online ahead of print. ABSTRACT Corneal endothelium is mostly sensitive to oxidative pressure and mitochondrial dysfunction. However, the oxidative-antioxidant mechanism of corneal endothelial cells (CECs) remains partially defined. Silent information regulator 1 (SIRT1) is a well-studied therapeutic target of oxidative damage. This study aimed to determine the […]