Remote ischemic preconditioning-induced late cardioprotection: possible role of melatonin-mitoKATP-H2S signaling pathway
Acta Cir Bras. 2023 May 15;38:e380423. doi: 10.1590/acb380423. eCollection 2023. ABSTRACT PURPOSE: Remote ischemic preconditioning (RIPC) confers cardioprotection against ischemia reperfusion (IR) injury. However, the precise mechanisms involved in RIPC-induced cardioprotection are not fully explored. The present study was aimed to identify the role of melatonin in RIPC-induced late cardioprotective effects in rats and to […]
Suppression of NLRP3/Caspase-1/GSDMD Mediated Corneal Epithelium Pyroptosis Using Melatonin-Loaded Liposomes to Inhibit Benzalkonium Chloride-Induced Dry Eye Disease
Int J Nanomedicine. 2023 May 9;18:2447-2463. doi: 10.2147/IJN.S403337. eCollection 2023. ABSTRACT INTRODUCTION: Benzalkonium chloride (BAC) is widely employed as a preservative in eye drops, which will cause the death of corneal epithelial cells due to ROS production, DNA strand breakage, and mitochondrial dysfunction, resulting in dry eye disease (DED)-like changes in ocular surface tissues. In […]
JP1 normalizes tumor vasculature to suppress metastasis and facilitate drug delivery by inhibiting IL8
JCI Insight. 2023 May 16:e161675. doi: 10.1172/jci.insight.161675. Online ahead of print. ABSTRACT Tumor vascular normalization prevents tumor cells from breaking through the basement membrane and entering the vasculature, and then inhibiting metastasis initiation. In this study, we reported that the anti-tumor peptide JP1 regulates the mitochondria metabolic reprogramming through AMPK/FOXO3a/UQCRC2 signaling, which improves the tumor […]
Biallelic variants in Ribonuclease Inhibitor (RNH1), an inflammasome modulator, are associated with a distinctive subtype of acute necrotizing encephalopathy
Genet Med. 2023 May 13:100897. doi: 10.1016/j.gim.2023.100897. Online ahead of print. ABSTRACT PURPOSE: Mendelian etiologies for acute encephalopathies in previously healthy children are poorly understood, with the exception of RAN Binding Protein 2 (RANBP2) associated Acute Necrotizing Encephalopathy sub-type 1 (ANE1). We provide clinical, genetic and neuroradiological evidence that biallelic variants in ribonuclease inhibitor (RNH1) […]
Anaphylatoxin C5a receptor signaling induces mitochondrial fusion and sensitizes retina pigment epithelial cells to oxidative stress
Biochim Biophys Acta Gen Subj. 2023 May 13:130374. doi: 10.1016/j.bbagen.2023.130374. Online ahead of print. ABSTRACT Mitochondrial dynamics is a morphological balance between fragmented and elongated shapes, reflecting mitochondrial metabolic status, cellular damage, and mitochondrial dysfunction. The anaphylatoxin C5a derived from complement component 5 cleavage, enhances cellular responses involved in pathological stimulation, innate immune responses, and […]
Mitochondria and the eye-manifestations of mitochondrial diseases and their management
Eye (Lond). 2023 Apr 25. doi: 10.1038/s41433-023-02523-x. Online ahead of print. ABSTRACT Historically, distinct mitochondrial syndromes were recognised clinically by their ocular features. Due to their predilection for metabolically active tissue, mitochondrial diseases frequently involve the eye, resulting in a range of ophthalmic manifestations including progressive external ophthalmoplegia, retinopathy and optic neuropathy, as well as […]
lncRNA TUG1 regulates Smac/DIABLO expression by competitively inhibiting miR-29b and modulates the apoptosis of lens epithelial cells in age-related cataracts
Chin Med J (Engl). 2023 Apr 26. doi: 10.1097/CM9.0000000000002530. Online ahead of print. ABSTRACT BACKGROUND: As one of the early discovered long non-coding RNAs (lncRNA), taurine upregulation gene 1 (TUG1) has been widely expressed in a variety of tumors. Moreover, it promotes cell proliferation, differentiation, apoptosis, and migration. However, our understanding of its importance in […]
Wolfram syndrome: new pathophysiological insights and therapeutic strategies
Ther Adv Rare Dis. 2021 Aug 16;2:26330040211039518. doi: 10.1177/26330040211039518. eCollection 2021 Jan-Dec. ABSTRACT Wolfram Syndrome (WS) is an ultra-rare, progressive neurodegenerative disease characterized by early-onset diabetes mellitus and irreversible loss of vision, secondary to optic nerve degeneration. Visual loss in WS is an important cause of registrable blindness in children and young adults and the […]
Mitochondrial Quality Control and Metabolic Memory Phenomenon Associated with Continued Progression of Diabetic Retinopathy
Int J Mol Sci. 2023 Apr 29;24(9):8076. doi: 10.3390/ijms24098076. ABSTRACT Diabetic retinopathy continues to progress even when hyperglycemia is terminated, suggesting a ‘metabolic memory’ phenomenon. Mitochondrial dysfunction is closely associated with the development of diabetic retinopathy, and mitochondria remain dysfunctional. Quality control of mitochondria requires a fine balance between mitochondrial fission-fusion, removal of the damaged […]
Tunneling nanotubes-based intercellular mitochondrial trafficking as a novel therapeutic target in dry eye
Exp Eye Res. 2023 May 9:109497. doi: 10.1016/j.exer.2023.109497. Online ahead of print. ABSTRACT Cell-to-cell mitochondria transfer via tunneling nanotubes (TNTs) has recently been revealed as a spontaneous way to protect damaged cells. Previously, we have reported mesenchymal stem cells (MSCs) can rescue retinal ganglion cell and corneal epithelium through intercellular mitochondrial trafficking. Mitochondrial damage and […]