Healthcare resource utilization of patients with mitochondrial disease in an outpatient hospital setting
Orphanet J Rare Dis. 2023 May 29;18(1):129. doi: 10.1186/s13023-023-02746-x. ABSTRACT BACKGROUND AND OBJECTIVES: Mitochondrial diseases present as multi-system disorders requiring a comprehensive multidisciplinary approach. The data on healthcare resource utilization associated with mitochondrial diseases and the clinical drivers of these costs are limited including for the out-patient setting where the majority of the clinical care […]
Dysfunctional Autophagy, Proteostasis, and Mitochondria as a Prelude to Age-Related Macular Degeneration
Int J Mol Sci. 2023 May 15;24(10):8763. doi: 10.3390/ijms24108763. ABSTRACT Retinal pigment epithelial (RPE) cell dysfunction is a key driving force of AMD. RPE cells form a metabolic interface between photoreceptors and choriocapillaris, performing essential functions for retinal homeostasis. Through their multiple functions, RPE cells are constantly exposed to oxidative stress, which leads to the […]
CORM-A1 Alleviates Pro-Atherogenic Manifestations via miR-34a-5p Downregulation and an Improved Mitochondrial Function
Antioxidants (Basel). 2023 Apr 25;12(5):997. doi: 10.3390/antiox12050997. ABSTRACT Atherogenesis involves multiple cell types undergoing robust metabolic processes resulting in mitochondrial dysfunction, elevated reactive oxygen species (ROS), and consequent oxidative stress. Carbon monoxide (CO) has been recently explored for its anti-atherogenic potency; however, the effects of CO on ROS generation and mitochondrial dysfunction in atherosclerosis remain […]
Traumatic Brain Injury Alters Cerebral Concentrations and Redox States of Coenzymes Q9 and Q10 in the Rat
Antioxidants (Basel). 2023 Apr 23;12(5):985. doi: 10.3390/antiox12050985. ABSTRACT To date, there is no information on the effect of TBI on the changes in brain CoQ levels and possible variations in its redox state. In this study, we induced graded TBIs (mild TBI, mTBI and severe TBI, sTBI) in male rats, using the weight-drop closed-head impact […]
NFAT5 Restricts Bovine Herpesvirus 1 Productive Infection in MDBK Cell Cultures
Microbiol Spectr. 2023 May 25:e0011723. doi: 10.1128/spectrum.00117-23. Online ahead of print. ABSTRACT Bovine herpesvirus 1 (BoHV-1), an important bovine viral pathogen, causes severe disease in the upper respiratory tract and reproductive system. Tonicity-responsive enhancer-binding protein (TonEBP), also known as nuclear factor of activated T cells 5 (NFAT5), is a pleiotropic stress protein involved in a […]
Klotho prevents transforming growth factor-β2-induced senescent-like morphological changes in the retinal pigment epithelium
Cell Death Dis. 2023 May 20;14(5):334. doi: 10.1038/s41419-023-05851-8. ABSTRACT Degenerative changes of the retinal pigment epithelium (RPE) triggered by transforming growth factor-β2 (TGF-β2) and oxidative stress play a critical role in the progression of age-related macular degeneration (AMD). The expression of α-klotho, an antiaging protein, declines with age, increasing the risk factors for age-related diseases. […]
Non-invasive treatment of ischemia/reperfusion injury: Effective transmission of therapeutic near-infrared light into the human brain through soft skin-conforming silicone waveguides
Bioeng Transl Med. 2023 Feb 7;8(3):e10496. doi: 10.1002/btm2.10496. eCollection 2023 May. ABSTRACT Noninvasive delivery of near-infrared light (IRL) to human tissues has been researched as a treatment for several acute and chronic disease conditions. We recently showed that use of specific IRL wavelengths, which inhibit the mitochondrial enzyme cytochrome c oxidase (COX), leads to robust […]
Mitochondrial dysfunction in glaucomatous degeneration
Int J Ophthalmol. 2023 May 18;16(5):811-823. doi: 10.18240/ijo.2023.05.20. eCollection 2023. ABSTRACT Glaucoma is a kind of optic neuropathy mainly manifested in the permanent death of retinal ganglion cells (RGCs), atrophy of the optic nerve, and loss of visual ability. The main risk factors for glaucoma consist of the pathological elevation of intraocular pressure (IOP) and […]
Reactive oxygen species-responsive mitochondria-targeted liposomal quercetin attenuates retinal ischemia-reperfusion injury via regulating SIRT1/FOXO3A and p38 MAPK signaling pathways
Bioeng Transl Med. 2022 Dec 1;8(3):e10460. doi: 10.1002/btm2.10460. eCollection 2023 May. ABSTRACT Retinal ischemia-reperfusion (RIR) injury is involved in the pathogenesis of various vision-threatening diseases. The overproduction of reactive oxygen species (ROS) is thought to be the main cause of RIR injury. A variety of natural products, including quercetin (Que), exhibit potent antioxidant activity. However, […]
The Presence of Guttae in Fuchs Endothelial Corneal Dystrophy Explants Correlates With Cellular Markers of Disease Progression
Invest Ophthalmol Vis Sci. 2023 May 1;64(5):13. doi: 10.1167/iovs.64.5.13. ABSTRACT PURPOSE: Fuchs endothelial corneal dystrophy (FECD) is characterized by an accelerated depletion of corneal endothelial cells. There is growing evidence that mitochondrial exhaustion is central in the pathology. Indeed, endothelial cells loss in FECD forces the remaining cells to increase their mitochondrial activity, leading to […]