Selective effects of estradiol on human corneal endothelial cells
Sci Rep. 2023 Sep 15;13(1):15279. doi: 10.1038/s41598-023-42290-z. ABSTRACT In Fuchs endothelial corneal dystrophy (FECD), mitochondrial and oxidative stresses in corneal endothelial cells (HCEnCs) contribute to cell demise and disease progression. FECD is more common in women than men, but the basis for this observation is poorly understood. To understand the sex disparity in FECD prevalence, […]
Ocular manifestations of the genetic renal tubulopathies
Ophthalmic Genet. 2023 Sep 13:1-15. doi: 10.1080/13816810.2023.2253901. Online ahead of print. ABSTRACT BACKGROUND: The genetic tubulopathies are rare and heterogenous disorders that are often difficult to identify. This study examined the tubulopathy-causing genes for ocular associations that suggested their genetic basis and, in some cases, the affected gene. METHODS: Sixty-seven genes from the Genomics England […]
Contribution of common and rare variants to Asian neovascular age-related macular degeneration subtypes
Nat Commun. 2023 Sep 11;14(1):5574. doi: 10.1038/s41467-023-41256-z. ABSTRACT Neovascular age-related macular degeneration (nAMD), along with its clinical subtype known as polypoidal choroidal vasculopathy (PCV), are among the leading causes of vision loss in elderly Asians. In a genome-wide association study (GWAS) comprising 3,128 nAMD (1,555 PCV and 1,573 typical nAMD), and 5,493 controls of East […]
Research progress on the pathogenesis of diabetic retinopathy
BMC Ophthalmol. 2023 Sep 11;23(1):372. doi: 10.1186/s12886-023-03118-6. ABSTRACT Diabetic retinopathy is one of the most common and serious microvascular complications of diabetes mellitus. There are many factors leading to diabetic retinopathy, and its pathogenesis is still unclear. At present, there are still no effective measures for the early treatment of diabetic retinopathy, and the treatment […]
Mechanisms of Extraorbital Lacrimal Gland Aging in Mice: An Integrative Analysis of the Temporal Transcriptome
Invest Ophthalmol Vis Sci. 2023 Sep 1;64(12):18. doi: 10.1167/iovs.64.12.18. ABSTRACT PURPOSE: This study used high-throughput RNA sequencing (RNA-Seq) and bioinformatics analysis to investigate the altered transcriptome profile of aging lacrimal glands in mice that occurs over the course of a 24-hour cycle. METHODS: Male C57BL/6J mice aged 12 weeks (young) and 20 months (aging) were […]
Insulin-like growth factor binding protein-3 mediates hyperosmolar stress-induced mitophagy through the mechanistic target of rapamycin
J Biol Chem. 2023 Sep 8:105239. doi: 10.1016/j.jbc.2023.105239. Online ahead of print. ABSTRACT Hyperosmolarity of the ocular surface triggers inflammation and pathological damage in dry eye disease (DED). In addition to a reduction in quality of life, DED causes vision loss and when severe, blindness. Mitochondrial dysfunction occurs as a consequence of hyperosmolar stress. We […]
The RLR intrinsic antiviral system is expressed in neural retina and restricts lentiviral transduction of human Mueller cells
Exp Eye Res. 2023 Sep 7:109647. doi: 10.1016/j.exer.2023.109647. Online ahead of print. ABSTRACT The retinoic acid-inducible gene I (RIG)-I-like receptor (RLR) family of RNA sensor proteins plays a key role in the innate immune response to viral nucleic acids, including viral gene delivery vectors, but little is known about the expression of RLR proteins in […]
Probucol attenuates high glucose-induced Müller cell damage through enhancing the Nrf2/p62 signaling pathway
Int Ophthalmol. 2023 Sep 9. doi: 10.1007/s10792-023-02859-z. Online ahead of print. ABSTRACT PURPOSE: This study investigated the protective effect of probucol on Müller cells exposed to high glucose conditions and examined potential mechanisms of action. METHODS: Primary human retinal Müller cells were incubated with high glucose (HG, 35 mM) in the present or absence of […]
Pyrroloquinoline quinone drives ATP synthesis in vitro and in vivo and provides retinal ganglion cell neuroprotection
Acta Neuropathol Commun. 2023 Sep 8;11(1):146. doi: 10.1186/s40478-023-01642-6. ABSTRACT Retinal ganglion cells are highly metabolically active requiring strictly regulated metabolism and functional mitochondria to keep ATP levels in physiological range. Imbalances in metabolism and mitochondrial mechanisms can be sufficient to induce a depletion of ATP, thus altering retinal ganglion cell viability and increasing cell susceptibility […]
Physical Properties and Cellular Metabolic Characteristics of 3D Spheroids Are Possible Definitive Indices for the Biological Nature of Cancer-Associated Fibroblasts
Cells. 2023 Aug 28;12(17):2160. doi: 10.3390/cells12172160. ABSTRACT The current study’s objective was to elucidate some currently unknown biological indicators to evaluate the biological nature of cancer-associated fibroblasts (CAFs). For this purpose, four different CAFs, CAFS1, CAFS2, SCC17F and MO-1000, were established using surgical specimens from oral squamous cell carcinomas (OSCC) with different clinical malignant stages […]