Glucose controls glucagon secretion by regulating fatty acid oxidation in pancreatic alpha cells
Diabetes. 2023 Jul 26:db230056. doi: 10.2337/db23-0056. Online ahead of print. ABSTRACT Whole-body glucose homeostasis is coordinated through secretion of glucagon and insulin from pancreatic islets. When glucose is low, glucagon is released from α-cells to stimulate hepatic glucose production. However, the mechanisms that regulate glucagon secretion from pancreatic α-cells remain unclear. Here we show that […]
The role of mitochondrial genes on nuclear gene expression in neovascular age related macular degeneration: analysis of nuclear VEGF gene expression after ranibizumab treatment in cytoplasmic hybrid retinal pigment epithelial cell lines correlated with clinical evolution
Int J Retina Vitreous. 2023 Jul 25;9(1):44. doi: 10.1186/s40942-023-00476-7. ABSTRACT PURPOSE: The present study tests the hypothesis that mitochondrial genes have retrograde signaling capacity that influences the expression of nuclear genes related to angiogenesis pathways. Cytoplasmic hybrid (cybrid) in vitro cell lines with patient specific mitochondria inserted into an immortalized retinal pigment epithelial cell line […]
High-Fat Diet Alters Acylcarnitine Metabolism of the Retina and Retinal Pigment Epithelium/Choroidal Tissues in Laser-Induced Choroidal Neovascularization Rat Models
Mol Nutr Food Res. 2023 Jul 25:e2300080. doi: 10.1002/mnfr.202300080. Online ahead of print. ABSTRACT SCOPE: Choroidal neovascularization (CNV) is age-related macular degeneration’s (AMD) main pathological change. High-fat diet (HFD) is associated with a form of CNV; however, the specific mechanism is unclear. Mitochondrial dysfunction, characterized by abnormal acylcarnitine, occurs during metabolic screening of serum or […]
Correction: PSF functions as a repressor of hypoxia-induced angiogenesis by promoting mitochondrial function
Cell Commun Signal. 2023 Jul 24;21(1):183. doi: 10.1186/s12964-023-01237-7. NO ABSTRACT PMID:37488561 | DOI:10.1186/s12964-023-01237-7
Exome sequencing reveals IFT172 variants in patients with non-syndromic cholestatic liver disease
PLoS One. 2023 Jul 20;18(7):e0288907. doi: 10.1371/journal.pone.0288907. eCollection 2023. ABSTRACT BACKGROUND AND AIM: Gene defects contribute to the aetiology of intrahepatic cholestasis. We aimed to explore the outcome of whole-exome sequencing (WES) in a cohort of 51 patients with this diagnosis. PATIENTS AND METHODS: Both paediatric (n = 33) and adult (n = 18) patients […]
Mitochondrial DNA 13513G>A Mutation Causing Leber Hereditary Optic Neuropathy Associated With Adult-Onset Renal Failure
J Neuroophthalmol. 2023 Jul 21. doi: 10.1097/WNO.0000000000001946. Online ahead of print. ABSTRACT BACKGROUND: Leber hereditary optic neuropathy (LHON) is one of the more common mitochondrial diseases and is rarely associated with mitochondrial renal disease. We report 3 unrelated patients with a background of adult-onset renal failure who presented to us with LHON and were shown […]
Exposure to long wavelength light that improves aged mitochondrial function shifts acute cytokine expression in serum and the retina
PLoS One. 2023 Jul 21;18(7):e0284172. doi: 10.1371/journal.pone.0284172. eCollection 2023. ABSTRACT Aged mitochondrial function can be improved with long wavelength light exposure. This reduces cellular markers of inflammation and can improve system function from fly through to human. We have previously shown that with age there are increases in cytokine expression in mouse serum. Here, we […]
Aqueous Fluid Transcriptome Profiling Differentiates Between Non-Neovascular and Neovascular AMD
Invest Ophthalmol Vis Sci. 2023 Jul 3;64(10):26. doi: 10.1167/iovs.64.10.26. ABSTRACT PURPOSE: Early and intermediate non-neovascular AMD (NN-AMD) has the potential to progress to either advanced NN-AMD with geographic atrophy, or to neovascular AMD (N-AMD) with CNV. This exploratory study performed an unbiased analysis of aqueous humor transcriptome in patients with early or intermediate NN-AMD vs. […]
Diurnal proteome profile of the mouse cerebral cortex: Conditional deletion of the Bmal1 circadian clock gene elevates astrocyte protein levels and cell abundance in the neocortex and hippocampus
Glia. 2023 Jul 20. doi: 10.1002/glia.24443. Online ahead of print. ABSTRACT Circadian oscillators, defined by cellular 24 h clock gene rhythms, are found throughout the brain. Cerebral cortex-specific conditional knockout of the clock gene Bmal1 (Bmal1 CKO) leads to depressive-like behavior, but the molecular link from clock gene to altered behavior is unknown. Further, diurnal […]
Congenital cataracts affect the retinal visual cycle and mitochondrial function: A multi-omics study of GJA8 knockout rabbits
J Proteomics. 2023 Jul 17:104972. doi: 10.1016/j.jprot.2023.104972. Online ahead of print. ABSTRACT Congenital cataracts are a threat to visual development in children, and the visual impairment persists after surgical treatment; however, the mechanisms involved remain unclear. Previous clinical studies have identified the effect of congenital cataracts on retinal morphology and function. To further understand the […]