Category: Ophthalmology AND mitochondrial

Long-term Efficacy and Safety of Photobiomodulation in Dry Age-Related Macular Degeneration (LIGHTSITE III: 24-Month Analysis)

Retina. 2026 Mar 3. doi: 10.1097/IAE.0000000000004822. Online ahead of print. ABSTRACT PURPOSE: To evaluate the safety and efficacy of multiwavelength photobiomodulation (PBM) in nonexudative (dry) age-related macular degeneration (AMD). METHODS: LIGHTSITE III employed a double-masked, randomized, sham-controlled, parallel-group, prospective study design. Subjects were enrolled with a diagnosis of dry AMD and treated with multiwavelength PBM […]

Neuropilin-2 Deficiency Promotes Mitochondrial Dysfunction and NAD+-Dependent Cellular Senescence in Retinal Degeneration

Invest Ophthalmol Vis Sci. 2026 Mar 2;67(3):11. doi: 10.1167/iovs.67.3.11. ABSTRACT PURPOSE: Retinal pigment epithelial (RPE) dysfunction is a central pathological feature of retinal degenerative diseases, leading to irreversible vision loss. RPE dysfunction is substantially driven by mitochondrial impairment and senescence. However, the upstream regulators of these processes remain largely undefined. This study investigated the role […]

Bilateral optic neuropathy following prolonged linezolid use: A case report

IDCases. 2026 Feb 19;43:e02524. doi: 10.1016/j.idcr.2026.e02524. eCollection 2026. ABSTRACT This report describes a case of bilateral linezolid-associated optic neuropathy in a 65-year-old woman treated for Mycobacterium abscessus infection and highlights the importance of early recognition and intervention. The patient developed progressive, painless bilateral visual decline after more than six months of linezolid therapy. Ophthalmic examination […]

Physical exercise modulates T cell activity and mitigates synaptic dysfunction in multiple sclerosis through vagus nerve engagement

Brain Behav Immun. 2026 Mar 2:106523. doi: 10.1016/j.bbi.2026.106523. Online ahead of print. ABSTRACT Physical exercise (PE) exerts beneficial effects in people with multiple sclerosis (pwMS). Preclinical studies in mice with experimental autoimmune encephalomyelitis (EAE), an animal model of MS, indicate that PE may attenuate key pathological features of the disease-including immune dysregulation and inflammation-driven synaptotoxicity-although […]

Photoreceptor deletion of pyruvate dehydrogenase E1 subunit α1 induces retinal degeneration and reprograms retinal metabolism

Mol Metab. 2026 Mar 2:102343. doi: 10.1016/j.molmet.2026.102343. Online ahead of print. ABSTRACT Rod and cone photoreceptors are among the most energy-demanding cells in the body, exhibiting a high rate of ATP consumption. Their primary energy source is glucose, which is metabolized through both glycolysis and mitochondrial pyruvate oxidative phosphorylation. The pyruvate dehydrogenase E1 subunit α1 […]

A Heteroplasmic MT-CO2 m.8024G > A Variant Is Associated with Mitochondrial Bioenergetic Deficiency and Optic Atrophy

Mol Neurobiol. 2026 Mar 4;63(1):485. doi: 10.1007/s12035-026-05774-3. ABSTRACT Leber’s hereditary optic neuropathy (LHON) is a hereditary neurodegenerative disorder caused by pathogenic mitochondrial DNA (mtDNA) variants. While MT-CO2 defects are implicated in neurodegeneration, their direct association with optic atrophy has not been reported. We identify a heteroplasmic MT-CO2 variant, m.8024G > A (p.Glu147Lys), in a patient […]

cGAS-STING signaling in pollution-induced toxicity: mechanism and relieving medication

Apoptosis. 2026 Mar 3;31(3):81. doi: 10.1007/s10495-026-02301-6. ABSTRACT Environmental pollutants have long been a major threat to human health, and long-term or high-concentration exposure can trigger acute or chronic diseases. These hazards often mediate tissue dysfunction and drive disease progression by inducing cell senescence and cell death (including apoptosis, pyroptosis, and ferroptosis). In recent years, the […]

Beyond readthrough: ataluren restores mitochondrial function and reduces oxidative stress in FANCA-mutated cells via mTOR-DRP1 modulation

Cell Death Discov. 2026 Feb 28. doi: 10.1038/s41420-026-02983-6. Online ahead of print. ABSTRACT Fanconi anemia (FA) is a rare inherited bone marrow failure syndrome characterized by genomic instability, mitochondrial dysfunction, and oxidative stress. While the therapeutic potential of ataluren, a translational readthrough-inducing drug, has been investigated in FA cells carrying nonsense mutations, its broader metabolic […]

Exercise-Induced Irisin: A Novel Strategy for Neuroinflammation Alleviation and Neurorepair in Diabetic Retinopathy

Int J Mol Sci. 2026 Feb 14;27(4):1849. doi: 10.3390/ijms27041849. ABSTRACT Diabetic retinopathy (DR) stands as a classic microvascular complication of diabetes mellitus. DR is characterized by multidimensional pathological changes in retinal neurons, microvasculature and supportive cells, leading to an intricate damage network. It is predominantly marked by neuropathy, encompassing retinal neuronal dysfunction, aberrant activation of […]