Dual regulation of metabolic reprogramming and protein competitive modifications: the core role and mechanism of MRPL36 in glioblastoma malignant progression
J Exp Clin Cancer Res. 2026 Jun 18. doi: 10.1186/s13046-026-03764-w. Online ahead of print. ABSTRACT BACKGROUND: Glioblastoma (GBM) has an extremely poor prognosis. Abnormal mitochondrial function, metabolic disorders, and dysregulated ferroptosis all drive its malignant progression, and the underlying molecular regulatory mechanisms still need further clarification. This study focuses on the regulatory mechanisms linking mitochondrial […]
Therapeutic Potential of miR-196a in Protecting Corneal Endothelial Cells From Senescence Through Mitochondrial and TGF-beta Signaling Modulation
Transl Vis Sci Technol. 2026 Jun 1;15(6):23. doi: 10.1167/tvst.15.6.23. ABSTRACT PURPOSE: Corneal endothelial cells (CECs) play a vital role in maintaining corneal transparency and function, with their hexagonal morphology being a hallmark of proper cellular packing and barrier integrity. This study investigates the functional role of miR-196a in regulating key cellular processes, including viability, cell […]
Spatially resolved in vivo ratiometric imaging of mitochondrial quality control using co-registered confocal-OCT
Biomed Opt Express. 2026 May 8;17(6):2852-2864. doi: 10.1364/BOE.597380. eCollection 2026 Jun 1. ABSTRACT Mitochondrial quality control is essential for maintaining cellular bioenergetic homeostasis, but in vivo monitoring of its spatial dynamics remains difficult to quantify. Here we present a multimodal retinal imaging approach that enables spatially resolved ratiometric assessment of mitochondrial turnover using a hybrid […]
Targeting lysosomal pH restores mitochondrial quality control in GBA1-mutant Parkinson’s disease
Transl Neurodegener. 2026 Jun 17;15(1):27. doi: 10.1186/s40035-026-00559-z. ABSTRACT BACKGROUND: Heterozygous mutations in the glucocerebrosidase gene (GBA1), which encodes the lysosomal enzyme β-glucocerebrosidase (GCase), are a genetic risk factor for Parkinson’s disease (PD). The pathophysiological consequences of GBA1 mutations on dopaminergic neuronal function, especially their impact on lysosomal function, mitophagy, and mitochondrial bioenergetics, remain unclear. METHODS: […]
Targeting STAT3-mediated lipid metabolism reprogramming overcomes chemoresistance in acute myeloid leukemia
Cell Death Dis. 2026 Jun 17. doi: 10.1038/s41419-026-08988-4. Online ahead of print. ABSTRACT Chemotherapy resistance and intolerance present significant challenges in the effective treatment of acute myeloid leukemia (AML). However, the role of metabolic reprogramming, particularly lipid metabolic rewiring, in promoting chemotherapy resistance in leukemia has not been fully elucidated. Here, we found that multiple […]
SLC25A3 exports mitochondrial copper to metalate cytochrome c oxidase and prevent cuproptosis
Proc Natl Acad Sci U S A. 2026 Jun 23;123(25):e2612098123. doi: 10.1073/pnas.2612098123. Epub 2026 Jun 17. ABSTRACT Copper (Cu) is an essential cofactor for cytochrome c oxidase (CcO), a mitochondrial respiratory chain enzyme that is metalated in the intermembrane space (IMS) primarily using Cu derived from the mitochondrial matrix pool. While Cu import into the […]
Genetic and transcriptomic signatures of host control in HIV-1 infection
Retrovirology. 2026 Jun 16. doi: 10.1186/s12977-026-00679-4. Online ahead of print. ABSTRACT BACKGROUND: The interaction between HIV-1 and the host immune system plays a crucial role in the natural control and progression of the infection. Previous studies have identified APOBEC3G, Tetherin, SAMHD1, and SERINC5 as HIV-1 host restriction factors, which are counteracted by the viral proteins […]
Polycatechol-based iron predators disrupt fungal iron homeostasis to drive selective antifungal action
Proc Natl Acad Sci U S A. 2026 Jun 23;123(25):e2537796123. doi: 10.1073/pnas.2537796123. Epub 2026 Jun 15. ABSTRACT Fungal infections pose a growing global health challenge, exacerbated by a scarcity of effective treatments and rising drug resistance. Although cationic polymers emerge as promising antifungal candidates owing to structural tunability, design flexibility, and resistance to proteolytic degradation, […]
Age-Related Dry Eye Disease: Redefining a Distinct Subtype Driven by Aging
Ocul Surf. 2026 Jun 11:S1542-0124(26)00077-7. doi: 10.1016/j.jtos.2026.06.011. Online ahead of print. ABSTRACT Dry eye disease (DED) is highly prevalent in older adults and represents a growing public health burden in aging societies. Although age is a well-recognized risk factor for DED, it is still often treated as a background variable rather than an active biological […]
ZONAB Regulates DNA Methylation, Mitochondrial Function, and Entry into Cell Senescence of Endothelial Cells
Cells. 2026 May 31;15(11):1015. doi: 10.3390/cells15111015. ABSTRACT Regulation of the endothelial stress response is important for blood vessel homeostasis and angiogenesis, processes disrupted in common vascular diseases and ageing. Here, we discovered that the Y-box factor ZONAB (ZO-1-associated nucleic acid binding protein; YBX3), a gene associated with risk loci for severe vascular disorders, regulates endothelial […]