Metabolomic Analysis of Aqueous Humor to Predict Glaucoma Progression and Overall Survival After Glaucoma Surgery-The MISO II Study
Metabolites. 2026 Jan 29;16(2):100. doi: 10.3390/metabo16020100. ABSTRACT BACKGROUND/OBJECTIVES: Although advances in understanding glaucoma have been made, early detection remains challenging due to the asymptomatic nature of the disease. The Metabolomics In Surgical Ophthalmological Patients (MISO) study previously demonstrated that aqueous humor (AH) metabolomics can distinguish glaucoma patients from controls. We aimed to determine if the […]
Mitochondrial Resilience in Glaucoma: Targeting NAD(+) Metabolism and Oxidative Stress in Retinal Ganglion Cell Degeneration with Nicotinamide Riboside and Berberine: Preliminary Clinical Evidence
Diseases. 2026 Feb 2;14(2):56. doi: 10.3390/diseases14020056. ABSTRACT BACKGROUND: Glaucoma is a chronic neurodegenerative disorder characterized by the selective vulnerability of retinal ganglion cells (RGCs), in which mitochondrial dysfunction, redox imbalance, and impaired bioenergetic signaling play central pathogenetic roles. Mitochondrial homeostasis in RGCs critically depends on maintaining intracellular NAD+ pools, which support oxidative phosphorylation, sirtuin-mediated deacetylation, […]
Regulation of Mitochondrial Biogenesis in Diabetic Retinopathy
Cells. 2026 Feb 17;15(4):357. doi: 10.3390/cells15040357. ABSTRACT Mitochondrial dysfunction plays a major role in diabetic retinopathy development and in its resistance to halt after the reversal of hyperglycemia (metabolic memory). Diabetes also upregulates many long noncoding RNAs, RNAs with >200 nucleotides with no reading frame, and several of them resist reversal after hyperglycemia cessation. Our […]
mRNA Sequencing of Limbal Epithelial Cells and mRNA/miRNA Profiling of Limbal Stromal Cells in PAX6-Related Congenital Aniridia
Cells. 2026 Feb 13;15(4):340. doi: 10.3390/cells15040340. ABSTRACT The dysfunction of limbal epithelial cells (LECs) and limbal stromal cells (LSCs) in congenital aniridia remains incompletely understood. We aimed to analyze mRNA expression profiles of primary human LECs and LSCs, as well as microRNA (miRNA) expression in LSCs, from patients with congenital aniridia (AN-LECs and AN-LSCs). mRNA […]
Actin depolymerization promotes axon regeneration by restoring axonal mitochondrial transport in mouse models of optic neuropathy
Sci Transl Med. 2026 Feb 25;18(838):eadw0908. doi: 10.1126/scitranslmed.adw0908. Epub 2026 Feb 25. ABSTRACT Adult mammalian central nervous system (CNS) axons do not spontaneously regenerate after injury. We recently identified multiple genes that promote optic nerve regeneration, protect retinal ganglion cell (RGC) somata and axons, and preserve visual function in mouse glaucoma models. Here, we investigated […]
Natural killer cell-inspired dendritic mesoporous rare-earth nanoparticles potentiate X-ray-triggered reactive oxygen generation for low-dose radiotherapy-radiodynamic therapy
Bioact Mater. 2026 Feb 17;61:464-481. doi: 10.1016/j.bioactmat.2026.02.011. eCollection 2026 Jul. ABSTRACT The efficacy of traditional radiotherapy has been significantly limited by its severe side effects, tumor hypoxia, and insufficient tumor accumulation. To address these challenges, we developed a multifarious radio enhancer composed of NK cell-derived extracellular vesicle (NKEV)-cloaked dendritic mesoporous thulium oxide (Tm2O3) encapsulated with […]
AMPK Deficiency Induces Corneal Epithelial Barrier Dysfunction by Modulating Energy Homeostasis
Invest Ophthalmol Vis Sci. 2026 Feb 2;67(2):47. doi: 10.1167/iovs.67.2.47. ABSTRACT PURPOSE: This study aims to examine the impact of adenosine monophosphate-activated protein kinase (AMPK) on corneal epithelial barrier function and energy metabolism. METHODS: Corneal epithelial specific AMPK knockout mice were constructed to evaluate ocular surface phenotypes. In vitro experiments were performed using human corneal epithelial […]
Repair of Corneal Epithelial Defects
Prog Mol Subcell Biol. 2026;63:155-174. doi: 10.1007/978-3-032-17771-1_5. ABSTRACT The corneal epithelium, a stratified squamous non-keratinized layer of 50-60 μm thickness, forms the outermost barrier of the cornea and provides both optical clarity and protection against trauma, infection, and fluid imbalance. It plays a vital role in protecting the eye and maintaining visual clarity. A range […]
NOTCH2NLC GGC repeat expansions cause retinal neurodegeneration in neuronal intranuclear inclusion disease mouse model
Cell Biosci. 2026 Feb 23. doi: 10.1186/s13578-026-01542-x. Online ahead of print. ABSTRACT Neuronal intranuclear inclusion disease (NIID) patients frequently exhibit ocular abnormalities, yet the pathogenic mechanisms remain unclear. Using a transgenic mouse model ubiquitously expressing NOTCH2NLC with 98GGC repeats, we revealed that polyglycine aggregates, translated from the expanded GGC repeats, predominantly localize in PAX6- and […]
Molecular Mechanism of Mitochondrial Complex I Disruption by m.14484T>C Underlying Leber Hereditary Optic Neuropathy
bioRxiv [Preprint]. 2026 Jan 30:2026.01.28.701874. doi: 10.64898/2026.01.28.701874. ABSTRACT Leber’s Hereditary Optic Neuropathy (LHON) is a rare genetic condition and severe neurological disorder characterized by dysfunctional mitochondria under extreme oxidative stress, resulting in retinal ganglion cell death and subsequent rapid bilateral loss of central vision. The m.14484T>C mutation in the ND6 subunit of mitochondrial complex I […]