Use of 31 P magnetisation transfer magnetic resonance spectroscopy to measure ATP changes after 670 nm transcranial photobiomodulation in older adults
Aging Cell. 2023 Oct 6:e14005. doi: 10.1111/acel.14005. Online ahead of print. ABSTRACT Mitochondrial function declines with age, and many pathological processes in neurodegenerative diseases stem from this dysfunction when mitochondria fail to produce the necessary energy required. Photobiomodulation (PBM), long-wavelength light therapy, has been shown to rescue mitochondrial function in animal models and improve human […]
Early proteomic characteristics and changes in the optic nerve head, optic nerve, and retina in a rat model of ocular hypertension
Mol Cell Proteomics. 2023 Oct 2:100654. doi: 10.1016/j.mcpro.2023.100654. Online ahead of print. ABSTRACT The pathogenesis of glaucoma is still unknown. There are few studies on the dynamic change of tissue-specific and time-specific molecular pathophysiology caused by ocular hypertension (OHT). This study aimed to identify the early proteomic alterations in the retina, optic nerve head (ONH), […]
Repeated Low-Level Red-Light Therapy for Controlling Onset and Progression of Myopia-a Review
Int J Med Sci. 2023 Sep 4;20(10):1363-1376. doi: 10.7150/ijms.85746. eCollection 2023. ABSTRACT Repeated low-level red-light (RLRL), characterized by increased energy supply and cellular metabolism, thus enhancing metabolic repair processes, has gained persistent worldwide attention in recent years as a new novel scientific approach for therapeutic application in myopia. This therapeutic revolution led by RLRL therapy […]
CircRNA itchy E3 ubiquitin protein ligase improves mitochondrial dysfunction in sepsis-induced acute kidney injury by targeting microRNA-214-3p/ATP-binding cassette A1 axis
Ren Fail. 2023;45(2):2261552. doi: 10.1080/0886022X.2023.2261552. Epub 2023 Oct 2. ABSTRACT BACKGROUND: Circular RNAs (circRNAs) are promising biomarkers and therapeutic targets for acute kidney injury (AKI). In this study, we investigated the mechanism by which circRNA itchy E3 ubiquitin protein ligase (circ-ITCH) regulates sepsis-induced AKI. METHODS: A sepsis-induced AKI mouse model was created using LPS induction […]
5-aminolevulinate and CHIL3/CHI3L1 treatment amid ischemia aids liver metabolism and reduces ischemia-reperfusion injury
Theranostics. 2023 Aug 28;13(14):4802-4820. doi: 10.7150/thno.83163. eCollection 2023. ABSTRACT Rationale: Liver resection and transplantation surgeries are accompanied by hepatic ischemia-reperfusion (HIR) injury that hampers the subsequent liver recovery. Given that the liver is the main organ for metabolism and detoxification, ischemia-reperfusion in essence bestows metabolic stress upon the liver and disrupts local metabolic and immune […]
Genipin relieves diabetic retinopathy by down-regulation of advanced glycation end products via the mitochondrial metabolism related signaling pathway
World J Diabetes. 2023 Sep 15;14(9):1349-1368. doi: 10.4239/wjd.v14.i9.1349. ABSTRACT BACKGROUND: Glycation is an important step in aging and oxidative stress, which can lead to endothelial dysfunction and cause severe damage to the eyes or kidneys of diabetics. Inhibition of the formation of advanced glycation end products (AGEs) and their cell toxicity can be a useful […]
Shedding Light on Photobiomodulation Therapy for Age-Related Macular Degeneration: A Narrative Review
Ophthalmol Ther. 2023 Sep 28. doi: 10.1007/s40123-023-00812-y. Online ahead of print. ABSTRACT BACKGROUND: Photobiomodulation (PBM) relies on the pathophysiological mechanism whereby red to near-infrared light can target mitochondrial activity and promote ATP synthesis. Preclinical and clinical studies have shown promising results in treating intermediate age-related macular degeneration (AMD), since PBM can produce photochemical reactions in […]
TGF-β2 Induces Epithelial-Mesenchymal Transitions in 2D Planer and 3D Spheroids of the Human Corneal Stroma Fibroblasts in Different Manners
Biomedicines. 2023 Sep 12;11(9):2513. doi: 10.3390/biomedicines11092513. ABSTRACT To examine the epithelial-mesenchymal transition (EMT) that is induced on the human corneal stroma, two- and three-dimensional (2D and 3D) cultures of human corneal stroma fibroblasts (HCSFs) were used. In this study, HCSF 2D monolayers and 3D spheroids were characterized by (1) scanning electron microscopy (SEM), (2) trans-endothelial […]
Tacrolimus Improves Therapeutic Efficacy of Umbilical Cord Blood-Derived Mesenchymal Stem Cells in Diabetic Retinopathy by Suppressing DRP1-Mediated Mitochondrial Fission
Antioxidants (Basel). 2023 Sep 6;12(9):1727. doi: 10.3390/antiox12091727. ABSTRACT Diabetic retinopathy (DR) is a leading cause of blindness in diabetic patients. Umbilical cord blood-derived mesenchymal stem cells (UCB-MSCs) are emerging as a promising new drug for degenerative disease associated with diabetes. Recent studies have shown that high glucose-increased excessive calcium levels are a major risk factor […]
Mesoporous Titanium Dioxide Nanoparticles-Poly(N-isopropylacrylamide) Hydrogel Prepared by Electron Beam Irradiation Inhibits the Proliferation and Migration of Oral Squamous Cell Carcinoma Cells
Polymers (Basel). 2023 Sep 5;15(18):3659. doi: 10.3390/polym15183659. ABSTRACT An urgently needed approach for the treatment of oral squamous cell carcinoma (OSCC) is the development of novel drug delivery systems that offer targeted specificity and minimal toxic side effects. In this study, we developed an injectable and temperature-sensitive composite hydrogel by combining mesoporous titanium dioxide nanoparticles […]