Neuropathic corneal pain: Tear proteomic and neuromediator profiles, imaging features, and clinical manifestations
Am J Ophthalmol. 2024 Mar 21:S0002-9394(24)00117-X. doi: 10.1016/j.ajo.2024.03.015. Online ahead of print. ABSTRACT PURPOSE: To investigate the tear proteomic and neuromediator profiles, in vivo confocal microscopy (IVCM) imaging features, and clinical manifestations in neuropathic corneal pain (NCP) patients. DESIGN: Cross-sectional study. METHODS: Twenty NCP patients and twenty age-matched controls were recruited. All subjects were evaluated […]
CRISPR editing of anti-anemia drug target rescues independent preclinical models of retinitis pigmentosa
Cell Rep Med. 2024 Mar 15:101459. doi: 10.1016/j.xcrm.2024.101459. Online ahead of print. ABSTRACT Retinitis pigmentosa (RP) is one of the most common forms of hereditary neurodegeneration. It is caused by one or more of at least 3,100 mutations in over 80 genes that are primarily expressed in rod photoreceptors. In RP, the primary rod-death phase […]
Sirt3 Protects Retinal Pigment Epithelial Cells From High Glucose-Induced Injury by Promoting Mitophagy Through the AMPK/mTOR/ULK1 Pathway
Transl Vis Sci Technol. 2024 Mar 1;13(3):19. doi: 10.1167/tvst.13.3.19. ABSTRACT PURPOSE: The regulation of mitophagy by Sirt3 has rarely been studied in ocular diseases. In the present study, we determined the effects of Sirt3 on AMPK/mTOR/ULK1 signaling pathway-mediated mitophagy in retinal pigment epithelial (RPE) cells in a high glucose environment. METHODS: The mRNA expression levels […]
Human ocular thelaziasis with genetic analysis in Niigata Prefecture, Japan: A case report on an emerging zoonosis
Am J Ophthalmol Case Rep. 2024 Mar 9;34:102030. doi: 10.1016/j.ajoc.2024.102030. eCollection 2024 Jun. ABSTRACT PURPOSE: We report the clinical findings and molecular identification of ocular Thelazia callipaeda from Niigata Prefecture in the Hokuriku area of Japan during winter. OBSERVATIONS: A 77-year-old male visited an ophthalmology clinic in Niigata Prefecture in January 2022 after a 2-week-duration […]
Glial Cell Activation and Immune Responses in Glaucoma: A Systematic Review of Human Postmortem Studies of the Retina and Optic Nerve
Aging Dis. 2024 Mar 2. doi: 10.14336/AD.2024.0103. Online ahead of print. ABSTRACT Although researched extensively the understanding regarding mechanisms underlying glaucoma pathogenesis remains limited. Further, the exact mechanism behind neuronal death remains elusive. The role of neuroinflammation in retinal ganglion cell (RGC) death has been prominently theorised. This review provides a comprehensive summary of neuroinflammatory […]
Quantifying nanoscopic alterations associated with mitochondrial dysfunction using three-dimensional single-molecule localization microscopy
Biomed Opt Express. 2024 Feb 12;15(3):1571-1584. doi: 10.1364/BOE.510351. eCollection 2024 Mar 1. ABSTRACT Mitochondrial morphology provides unique insights into their integrity and function. Among fluorescence microscopy techniques, 3D super-resolution microscopy uniquely enables the analysis of mitochondrial morphological features individually. However, there is a lack of tools to extract morphological parameters from super-resolution images of mitochondria. […]
p38 MAPK inhibitor SB202190 suppresses ferroptosis in the glutamate-induced retinal excitotoxicity glaucoma model
Neural Regen Res. 2024 Oct 1;19(10):2299-2309. doi: 10.4103/1673-5374.391193. Epub 2023 Dec 21. ABSTRACT JOURNAL/nrgr/04.03/01300535-202410000-00031/figure1/v/2024-02-06T055622Z/r/image-tiff Glutamate excitotoxicity has been shown to play an important role in glaucoma, and glutamate can induce ferroptosis. The p38 mitogen-activated protein kinase (MAPK) pathway inhibitor SB202190 has a potential ability to suppress ferroptosis, and its downstream targets, such as p53, have […]
Acetazolamide Challenge Changes Outer Retina Bioenergy-Linked and Anatomical OCT Biomarkers Depending on Mouse Strain
Invest Ophthalmol Vis Sci. 2024 Mar 5;65(3):21. doi: 10.1167/iovs.65.3.21. ABSTRACT PURPOSE: The purpose of this study was to test the hypothesis that optical coherence tomography (OCT) bioenergy-linked and anatomical biomarkers are responsive to an acetazolamide (ACZ) provocation. METHODS: C57BL/6J mice (B6J, a strain with relatively inefficient mitochondria) and 129S6/ev mice (S6, a strain with relatively […]
Curcumin relieves oxaliplatin-induced neuropathic pain via reducing inflammation and activating antioxidant response
Cell Biol Int. 2024 Mar 13. doi: 10.1002/cbin.12153. Online ahead of print. ABSTRACT Oxaliplatin (OXA) has shown high effectiveness in the treatment of cancers, but its anticancer clinical effects often induce neurotoxicity leading to neuropathic pain. Oxidative damage and NLRP3 inflammasome play important roles in neuropathic pain development. Here, neuropathic pain mouse model was constructed […]
Digenic Leigh syndrome on the background of the m.11778G>A Leber hereditary optic neuropathy variant
Brain. 2024 Mar 13:awae057. doi: 10.1093/brain/awae057. Online ahead of print. ABSTRACT Leigh syndrome spectrum (LSS) is a primary mitochondrial disorder defined neuropathologically by a subacute necrotizing encephalomyelopathy and characterised by bilateral basal ganglia and/or brainstem lesions. LSS is associated with variants in several mitochondrial DNA (mtDNA) genes and more than 100 nuclear genes, most often […]