Trends Mol Med. 2024 Jul 24:S1471-4914(24)00187-4. doi: 10.1016/j.molmed.2024.07.001. Online ahead of print.
ABSTRACT
Lactylation, a post-translational modification (PTM) induced by lactate, has crucial roles in the regulation of transcription, DNA repair, and mitochondrial metabolism. Here, we discuss the role of lactate/lactylation signaling in regulating eye morphogenesis and retinal homeostasis, as well as various ophthalmic disorders, such as myopia, intraocular malignancies, and retinal angiogenesis.
PMID:39054226 | DOI:10.1016/j.molmed.2024.07.001