Letter to the editor on: prophylactic nicotinamide treatment protects from rotenone-induced neurodegeneration by increasing mitochondrial content and volume
Acta Neuropathol Commun. 2024 Apr 5;12(1):53. doi: 10.1186/s40478-024-01768-1. NO ABSTRACT PMID:38581047 | DOI:10.1186/s40478-024-01768-1
PGC-1α regulates the interplay between oxidative stress, senescence and autophagy in the ageing retina important in age-related macular degeneration
J Cell Mol Med. 2024 Apr;28(8):e18051. doi: 10.1111/jcmm.18051. ABSTRACT We previously showed that mice with knockout in the peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A) gene encoding the PGC-1α protein, and nuclear factor erythroid 2 like 2 (NFE2L2) gene, exhibited some features of the age-related macular degeneration (AMD) phenotype. To further explore the mechanism behind […]
Secondary follicles enable efficient germline mtDNA base editing at hard-to-edit site
Mol Ther Nucleic Acids. 2024 Mar 11;35(2):102170. doi: 10.1016/j.omtn.2024.102170. eCollection 2024 Jun 11. ABSTRACT Efficient germline mtDNA editing is required to construct disease-related animal models and future gene therapy. Recently, the DddA-derived cytosine base editors (DdCBEs) have made mitochondrial genome (mtDNA) precise editing possible. However, there still exist challenges for editing some mtDNA sites in […]
Correlative light and X-ray tomography jointly unveil the critical role of connexin43 channels on inflammation-induced cellular ultrastructural alterations
Heliyon. 2024 Mar 21;10(7):e27888. doi: 10.1016/j.heliyon.2024.e27888. eCollection 2024 Apr 15. ABSTRACT Non-junctional connexin43 (Cx43) plasma membrane hemichannels have been implicated in several inflammatory diseases, particularly playing a role in ATP release that triggers activation of the inflammasome. Therapies targeting the blocking of the hemichannels to prevent the pathological release or uptake of ions and signalling […]
Real-time monitoring of mitochondrial oxygenation during machine perfusion using resonance Raman spectroscopy predicts organ function
Sci Rep. 2024 Mar 27;14(1):7328. doi: 10.1038/s41598-024-57773-w. ABSTRACT Organ transplantation is a life-saving procedure affecting over 100,000 people on the transplant waitlist. Ischemia reperfusion injury (IRI) is a major challenge in the field as it can cause post-transplantation complications and limit the use of organs from extended criteria donors. Machine perfusion technology has the potential […]
Transketolase promotes MAFLD by limiting inosine-induced mitochondrial activity
Cell Metab. 2024 Mar 23:S1550-4131(24)00082-2. doi: 10.1016/j.cmet.2024.03.003. Online ahead of print. ABSTRACT Metabolic dysfunction-associated fatty liver disease (MAFLD) has a global prevalence of about 25% and no approved therapy. Using metabolomic and proteomic analyses, we identified high expression of hepatic transketolase (TKT), a metabolic enzyme of the pentose phosphate pathway, in human and mouse MAFLD. […]
The Role and Mechanism of Nicotinamide Riboside in Oxidative Damage and a Fibrosis Model of Trabecular Meshwork Cells
Transl Vis Sci Technol. 2024 Mar 1;13(3):24. doi: 10.1167/tvst.13.3.24. ABSTRACT PURPOSE: To investigate the potential effects and mechanism of nicotinamide riboside (NR) on the oxidative stress and fibrosis model of human trabecular meshwork (HTM) cell line cells. METHODS: HTM cells were pretreated with NR, followed by the induction of oxidative injury and fibrosis by hydrogen […]
Diabetic Retinopathy and Regulation of Mitochondrial Glutathione-Glutathione Peroxidase Axis in Hyperhomocysteinemia
Antioxidants (Basel). 2024 Feb 20;13(3):254. doi: 10.3390/antiox13030254. ABSTRACT Diabetic patients have elevated homocysteine levels, and hyperhomocysteinemia is shown to exacerbate mitochondrial damage, which plays a central role in diabetic retinopathy. Glutathione peroxidases (GPx) catalyze hydrogen peroxide (H2O2) reduction using glutathione (GSH) as a cofactor. GSH and GPx are mainly cytosolic but are also present in […]
CASK Mediates Oxidative Stress-Induced Microglial Apoptosis-Inducing Factor-Independent Parthanatos Cell Death via Promoting PARP-1 Hyperactivation and Mitochondrial Dysfunction
Antioxidants (Basel). 2024 Mar 13;13(3):343. doi: 10.3390/antiox13030343. ABSTRACT Calcium/calmodulin-dependent serine protein kinase (CASK) is a scaffold protein and plays critical roles in neuronal synaptic formation and brain development. Previously, CASK was shown to associate with EGFR to maintain the vulval cell differentiation in C. elegans. In this study, we explored the role of CASK in […]
Nucleus-Mitochondria Contact Sites Are Associated With Asynthetic Fission in Zebrafish Skin
Contact (Thousand Oaks). 2024 Mar 14;7:25152564241239445. doi: 10.1177/25152564241239445. eCollection 2024 Jan-Dec. ABSTRACT Rapid increase in body surface area of growing zebrafish larvae (Danio rario) is partially accomplished by asynthetic fission of superficial epithelial cells (SECs) of the skin. There are two cycles of this atypical form of cell division which is unaccompanied by DNA replication; […]