Overexpression of TRPV1 activates autophagy in human lens epithelial cells under hyperosmotic stress through Ca2+-dependent AMPK/mTOR pathway
Int J Ophthalmol. 2024 Mar 18;17(3):420-434. doi: 10.18240/ijo.2024.03.03. eCollection 2024. ABSTRACT AIM: To explore whether autophagy functions as a cellular adaptation mechanism in lens epithelial cells (LECs) under hyperosmotic stress. METHODS: LECs were treated with hyperosmotic stress at the concentration of 270, 300, 400, 500, or 600 mOsm for 6, 12, 18, 24h in vitro. […]
Mitochondrial DNA-Associated Leigh Syndrome Spectrum
2003 Oct 30 [updated 2024 May 9]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024. ABSTRACT CLINICAL CHARACTERISTICS: Mitochondrial DNA-associated Leigh syndrome spectrum (mtDNA-LSS) is part of a continuum of progressive neurodegenerative disorders caused by abnormalities […]
Mitochondria Energy Metabolism Depression as Novel Adjuvant to Sensitize Radiotherapy and Inhibit Radiation Induced-Pulmonary Fibrosis
Adv Sci (Weinh). 2024 May 7:e2401394. doi: 10.1002/advs.202401394. Online ahead of print. ABSTRACT Currently, the typical combination therapy of programmed death ligand-1 (PD-L1) antibodies with radiotherapy (RT) still exhibits impaired immunogenic antitumor response in clinical due to lessened DNA damage and acquired immune tolerance via the upregulation of some other immune checkpoint inhibitors. Apart from […]
Galactose-Replacement Unmasks the Biochemical Consequences of the G11778A Mitochondrial DNA Mutation of LHON in Patient-Derived Fibroblasts
Exp Cell Res. 2024 May 4:114075. doi: 10.1016/j.yexcr.2024.114075. Online ahead of print. ABSTRACT Leber’s hereditary optic neuropathy (LHON) is a visual impairment associated with mutations of mitochondrial genes encoding elements of the electron transport chain. While much is known about the genetics of LHON, the cellular pathophysiology leading to retinal ganglion cell degeneration and subsequent […]
Mitochondria-Targeted Nanoadjuvants Induced Multi-Functional Immune-Microenvironment Remodeling to Sensitize Tumor Radio-Immunotherapy
Adv Sci (Weinh). 2024 May 5:e2400297. doi: 10.1002/advs.202400297. Online ahead of print. ABSTRACT It is newly revealed that collagen works as a physical barrier to tumor immune infiltration, oxygen perfusion, and immune depressor in solid tumors. Meanwhile, after radiotherapy (RT), the programmed death ligand-1 (PD-L1) overexpression and transforming growth factor-β (TGF-β) excessive secretion would accelerate […]
Mitochondrial retinopathies and optic neuropathies: the impact of retinal imaging on modern understanding of pathogenesis, diagnosis, and management
Prog Retin Eye Res. 2024 May 2:101264. doi: 10.1016/j.preteyeres.2024.101264. Online ahead of print. ABSTRACT Advancements in ocular imaging have significantly broadened our comprehension of mitochondrial retinopathies and optic neuropathies by examining the structural and pathological aspects of the retina and optic nerve in these conditions. This article aims to review the prominent imaging characteristics associated […]
Near infrared/ red light therapy a potential countermeasure for mitochondrial dysfunction in spaceflight associated neuro-ocular syndrome (SANS)
Eye (Lond). 2024 May 3. doi: 10.1038/s41433-024-03091-4. Online ahead of print. NO ABSTRACT PMID:38702514 | DOI:10.1038/s41433-024-03091-4
Gossypol acetic acid regulates leukemia stem cells by degrading LRPPRC via inhibiting IL-6/JAK1/STAT3 signaling or resulting mitochondrial dysfunction
World J Stem Cells. 2024 Apr 26;16(4):444-458. doi: 10.4252/wjsc.v16.i4.444. ABSTRACT BACKGROUND: Leukemia stem cells (LSCs) are found to be one of the main factors contributing to poor therapeutic effects in acute myeloid leukemia (AML), as they are protected by the bone marrow microenvironment (BMM) against conventional therapies. Gossypol acetic acid (GAA), which is extracted from […]
Ocular Brugia pahangi Filariasis Complicated by Severe Macular Damage in Thailand: Case Report and Literature Review
Am J Trop Med Hyg. 2024 Apr 30:tpmd240047. doi: 10.4269/ajtmh.24-0047. Online ahead of print. ABSTRACT Extralymphatic filariasis caused by filaria of zoonotic origins has been frequently reported in Thailand over recent years. Here, we report the first case of ocular filariasis in a 7.5-year-old Thai boy who initially presented with progressive conjunctival redness and blurred […]
Cytosolic DNA initiates a vicious circle of aging-related endothelial inflammation and mitochondrial dysfunction via STING: the inhibitory effect of Cilostazol
Acta Pharmacol Sin. 2024 Apr 30. doi: 10.1038/s41401-024-01281-0. Online ahead of print. ABSTRACT Endothelial senescence, aging-related inflammation, and mitochondrial dysfunction are prominent features of vascular aging and contribute to the development of aging-associated vascular disease. Accumulating evidence indicates that DNA damage occurs in aging vascular cells, especially in endothelial cells (ECs). However, the mechanism of […]