Early Proteomic and Metabolic Signatures of Liver and Eye in OAT-Deficient Mice
Exp Eye Res. 2026 Jun 29:111140. doi: 10.1016/j.exer.2026.111140. Online ahead of print. ABSTRACT Ornithine aminotransferase (OAT) deficiency causes hyperornithinemia and gyrate atrophy (GA) of the choroid and retina, a rare inherited retinal degeneration. To understand the early molecular changes that make the eye susceptible to damage, we performed quantitative proteomic and metabolomic profiling of liver, […]
Lipocalin-2 Restores Mitochondrial and Antioxidant Adaptation in a Strain-Specific Manner During LPS Induced Sepsis
J Cell Physiol. 2026 Jun;241(6):e70205. doi: 10.1002/jcp.70205. ABSTRACT Sepsis induces profound metabolic and mitochondrial dysfunction, contributing to multiple organ injury and mortality. Lipocalin-2 (Lcn2), an acute-phase protein, regulates iron homeostasis and oxidative stress, but its impact on mitochondrial resilience remains poorly understood. Here, we investigated the role of Lcn2 in modulating mitochondrial function and hepatic […]
Retraction notice to ‘Mitochondrial ferritin upregulation reduced oxidative stress and blood-brain-barrier disruption by maintaining cellular iron homeostasis in a neonatal rat model of germinal matrix hemorrhage’ [Experimental Neurology 374 (2024) 114703]
Exp Neurol. 2026 Jun 28:115735. doi: 10.1016/j.expneurol.2026.115735. Online ahead of print. NO ABSTRACT PMID:42366134 | DOI:10.1016/j.expneurol.2026.115735
NAD+ modulates mitochondrial vulnerability in MERTK-associated models of retinitis pigmentosa
Nat Commun. 2026 Jun 27. doi: 10.1038/s41467-026-74400-6. Online ahead of print. ABSTRACT Retinitis pigmentosa (RP) is the most common inherited retinal degenerative disease leading to blindness. RP is characterized by progressive loss of photoreceptors and retinal pigment epithelium (RPE), leading to retinal degeneration. The mechanisms that initiate RP and drive retinal vulnerability are poorly understood, […]
Diagnostic Yield and Clinical Impact of Comprehensive WES/WGS Testing Beyond Common Genetic Causes in Hereditary Optic Atrophy
Clin Genet. 2026 Jun 27. doi: 10.1111/cge.70203. Online ahead of print. ABSTRACT Hereditary optic atrophy is characterized by degeneration of retinal ganglion cells and may result from a wide range of genetic etiologies. While pathogenic variants in OPA1 and primary mitochondrial variants causing Leber hereditary optic neuropathy (LHON) account for a substantial proportion of cases, […]
Analysis of genetic risk factors for Leber hereditary optic neuropathy in the Polish population
J Appl Genet. 2026 Jun 27. doi: 10.1007/s13353-026-01090-7. Online ahead of print. ABSTRACT Leber hereditary optic neuropathy (LHON) is primarily caused by pathogenic mitochondrial DNA (mtDNA) variants, most commonly the m.11778G>A variant in the MT-ND4 gene. The presence of this variant alone is insufficient to trigger disease symptoms, of which vision loss is the hallmark. […]
Comprehensive, High-Spatiotemporal-Resolution Intravital Two-Photon Imaging of the Mouse Conventional Outflow Pathway: Green Intravital Imaging
Invest Ophthalmol Vis Sci. 2026 Jun 1;67(6):53. doi: 10.1167/iovs.67.6.53. ABSTRACT PURPOSE: To develop an intravital imaging method that comprehensively shows the mouse conventional outflow pathway at high spatiotemporal resolution and to investigate the fine structures and dynamics within this pathway. METHODS: Intravital two-photon imaging was performed using Green, Prox1-reporter, and mito-Dendra2 mice. Schlemm’s canal (SC) […]
Oxidative Stress in Glaucoma: From Pathogenic Mechanisms to Emerging Antioxidant Therapies
Antioxidants (Basel). 2026 Jun 14;15(6):751. doi: 10.3390/antiox15060751. ABSTRACT Glaucoma is the leading cause of irreversible blindness worldwide and is characterized by progressive retinal ganglion cell (RGC) loss and optic nerve degeneration. While elevated intraocular pressure (IOP) remains the primary modifiable risk factor, a certain proportion of patients continue to deteriorate despite adequate IOP control, pointing […]
Epigenetic-Mitochondrial-Metabolic Crosstalk in Retinal Pigment Epithelium (RPE) Dysfunction in Age-Related Macular Degeneration (AMD)
Antioxidants (Basel). 2026 Jun 4;15(6):713. doi: 10.3390/antiox15060713. ABSTRACT Age-related macular degeneration (AMD) is a leading cause of irreversible vision loss in older adults and is characterized by progressive dysfunction of the retinal pigment epithelium (RPE). Although genetic susceptibility and environmental exposure both contribute to disease risk, the mechanisms through which chronic metabolic and oxidative stress […]
Mitochondrial Dysfunction and Oxidative Stress in Retinal Degeneration: Mechanisms, Biomarkers, and Therapeutic Perspectives
Curr Issues Mol Biol. 2026 Jun 11;48(6):612. doi: 10.3390/cimb48060612. ABSTRACT Mitochondrial dysfunction and oxidative stress are increasingly recognized as key contributors to the development and progression of retinal degenerative diseases, including age-related macular degeneration and inherited retinal dystrophies. Growing evidence suggests that alterations in mitochondrial function, excessive production of reactive oxygen species, defective mitophagy, and […]