Storage of Corneas With Predissected Descemet Membrane in an Active Storage Machine
Transl Vis Sci Technol. 2026 Mar 2;15(3):19. doi: 10.1167/tvst.15.3.19. ABSTRACT PURPOSE: We previously demonstrated the superiority of an active storage machine (ASM; which restores a physiologic intraocular pressure [IOP]) over conventional passive storage for whole corneas. To reduce surgical time, corneas are often predissected in eye banks, 2 to 4 days before surgery for endothelial […]
Exosomes for Polycystic Ovary Syndrome Treatment: Mechanisms and Therapeutic Potential
Int J Nanomedicine. 2026 Jan 10;21:574044. doi: 10.2147/IJN.S574044. eCollection 2026. ABSTRACT Polycystic ovary syndrome (PCOS) is a major health concern for women of reproductive age and a leading cause of infertility and metabolic dysfunction. Current treatments mainly involve lifestyle modification and pharmacological therapies, such as oral contraceptives and metformin, and may also include laparoscopic ovarian […]
Histone H3K9 lactylation activates the TXNIP/NLRP3 pathway to drive macrophage inflammation after spinal cord injury
Redox Biol. 2026 Feb 26;92:104078. doi: 10.1016/j.redox.2026.104078. Online ahead of print. ABSTRACT Spinal cord injury (SCI) induces metabolic and immune disruptions that impede tissue repair. However, the underlying mechanisms are poorly understood. In this study, we identified lactate accumulation as a critical driver of macrophage-mediated inflammation through histone H3K9 lactylation (H3K9la). Targeted metabolomics revealed elevated […]
The aging cornea: from mechanisms to clinical applications
Ageing Res Rev. 2026 Mar 16:103103. doi: 10.1016/j.arr.2026.103103. Online ahead of print. ABSTRACT Aging is a multifactorial process characterized by a gradual decline in function, increased susceptibility to diseases, and diminished regenerative capacity. As the primary refractive structure and barrier of the eye, the cornea undergoes significant structural and functional changes during aging, making individuals […]
A preclinical candidate of cyclophilin D inhibition improves alcohol-associated liver injury
Cell Rep Med. 2026 Mar 17;7(3):102654. doi: 10.1016/j.xcrm.2026.102654. ABSTRACT Currently, no therapies are approved for alcohol-associated liver disease (ALD). Here, we identify cyclophilin D (CypD) as a critical mediator in the progression of ALD. We observe elevated expression of CypD in ALD patients and a corresponding mouse model. Hepatocyte-specific knockout of CypD mitigates hepatic mitochondrial […]
GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis
Adv Sci (Weinh). 2026 Mar 18:e22929. doi: 10.1002/advs.202522929. Online ahead of print. ABSTRACT Glaucoma is a leading cause of irreversible blindness worldwide. One hallmark of glaucoma is the degeneration of retinal ganglion cells (RGCs). In this study, a dual role for growth hormone-releasing hormone receptor (GHRHR) modulation under glaucoma-relevant conditions and complementary injury paradigms involving […]
A heterozygous pathogenic RPE65 variant phenocopies a mitochondrial retinopathy
Ophthalmic Genet. 2026 Mar 17:1-5. doi: 10.1080/13816810.2026.2631747. Online ahead of print. ABSTRACT The gene retinoid isomerohydrolase retinal pigment epithelium 65 (RPE65; OMIM# 180069), is abundantly expressed in the RPE and encodes an isomerohydrolase enzyme that catalyzes an essential step in the visual cycle by converting all-trans retinyl ester to 11-cis retinol. Most pathogenic variants in […]
A Case Report of Late-Onset Leber’s Hereditary Optic Neuropathy Diagnosed Following Vision Loss After Cataract Surgery
Neuroophthalmology. 2025 May 6;50(2):180-185. doi: 10.1080/01658107.2025.2495295. eCollection 2026. ABSTRACT Leber’s Hereditary Optic Neuropathy (LHON) is a rare mitochondrial disorder characterized by acute to subacute vision loss, predominantly affecting young males. We report a case of a 65-year-old male diagnosed with late-onset LHON after experiencing significant vision decline following cataract surgery. The patient initially presented with […]
Visual Loss from Leber’s Optic Neuropathy Presenting in a 76-Year-Old Man with the 14484 Mutations
Neuroophthalmology. 2025 May 19;50(2):159-166. doi: 10.1080/01658107.2025.2487842. eCollection 2026. ABSTRACT Leber’s Hereditary Optic Neuropathy (LHON) is an important hereditary optic neuropathy that typically causes bilateral visual loss, predominantly in male patients. While it usually manifests in young adults, it can uncommonly present in older individuals without a family history, potentially leading to diagnostic confusion. The mechanisms […]
Optic Atrophy Associated With a Mitochondrial G8363A Mutation in a Family
Clin Genet. 2026 Mar 18. doi: 10.1111/cge.70152. Online ahead of print. ABSTRACT We report a rare family of optic atrophy diseases associated with mitochondrial DNA G8363A transfer ribonucleic acid (RNA) cleavage mutations. This family does not exhibit the characteristic symptoms of myoclonic epilepsy or cutaneous lipomas, but instead presents with bilateral optic atrophy. The clinical […]