Mitochondrial Dysfunction and Diabetic Retinopathy: Research Progress from Pathogenic Mechanisms to Therapeutic Targets
Exp Eye Res. 2026 Jul 3:111157. doi: 10.1016/j.exer.2026.111157. Online ahead of print. ABSTRACT Diabetic retinopathy (DR) is one of the most common microvascular complications of diabetes mellitus (DM) and remains a major cause of visual impairment and blindness in adults. Accumulating evidence indicates that DR is not merely a microvascular disorder, but a complex neurovascular […]
High glucose-induced mitochondrial fission promotes Muller cell activation via suppression of the Hippo pathway
Mol Cell Biochem. 2026 Jul 3. doi: 10.1007/s11010-026-05625-8. Online ahead of print. ABSTRACT Diabetic retinopathy (DR) is the leading cause of blindness in diabetic patients, in which high glucose (HG)-induced Müller cell activation constitutes a central pathological event. This study aimed to untangle the critical role and mechanism of mitochondrial fission in this process. We […]
6PPD-quinone induces systemic and transgenerational effects in Caenorhabditis elegans
J Hazard Mater. 2026 Jun 25;514:142781. doi: 10.1016/j.jhazmat.2026.142781. Online ahead of print. ABSTRACT N-(1,3-dimethylbutyl)-N’-phenyl-p-phenylenediamine quinone (6PPD-Q), a redox-active transformation product of the tire antioxidant 6PPD, has emerged as a pervasive urban contaminant. Although acute lethality (LC50 ≥ 100 μg/L) occurs above most environmental concentrations, growing evidence indicates that environmentally relevant levels (0.1-10 μg/L), which overlap […]
AMPK Activation by AICAR Mitigates Hypoxic Corneal Damage Through Rebuilding Energy and Metabolic Homeostasis
Chem Biol Interact. 2026 Jul 2:112229. doi: 10.1016/j.cbi.2026.112229. Online ahead of print. ABSTRACT Hypoxia disrupts corneal physiological function by impairing energy metabolism. We identify AMP-activated protein kinase (AMPK) as a central regulator of coordinated metabolic adaptation in the hypoxic cornea. Using human corneal epithelial cells and an alkali burn-induced mouse model of corneal hypoxia, we […]
Archetypal Visual Field Analysis of Patients With Chronic Leber Hereditary Optic Neuropathy in Relation to Visual Recovery
Invest Ophthalmol Vis Sci. 2026 Jul 1;67(8):8. doi: 10.1167/iovs.67.8.8. ABSTRACT PURPOSE: To use the machine learning algorithm archetypal analysis (AA) to characterize visual field (VF) loss patterns in patients with chronic Leber hereditary optic neuropathy (LHON) and to determine whether these VF patterns differentiate for patients who recovered visual acuity (VA). METHODS: For patients with […]
Multi-targeted biomimetic CeO2-based nanoplatform for sepsis therapy via mitochondrial homeostasis
Int J Pharm X. 2026 Jun 15;12:100585. doi: 10.1016/j.ijpx.2026.100585. eCollection 2026 Dec. ABSTRACT Sepsis is a life – threatening systemic inflammatory response syndrome triggered by pathogenic infections, which is characterized by severe oxidative stress, immune dysregulation, and multiple organ dysfunction, accompanied by a high mortality rate. Its primary pathogenesis encompasses pathogen – induced immune overactivation, […]
AMPK orchestrates mitochondrial homeostasis via dynamics and mitophagy to combat hypoxia-induced energetic crisis in keratocytes
Cell Biol Toxicol. 2026 Jul 1. doi: 10.1007/s10565-026-10222-y. Online ahead of print. ABSTRACT BACKGROUND: Hypoxia disrupts corneal stromal physiology and alters cellular energy metabolism. This study aimed to elucidate the molecular role of the cellular energy sensor AMP-activated protein kinase (AMPK) in modulating the energy metabolism of human keratocytes (HKs) under hypoxic conditions and to […]
A Critical Role for Mitochondrial Dynamics in Cigarette Smoke Condensate-induced RPE Senescence
Free Radic Biol Med. 2026 Jul 1:S0891-5849(26)00915-9. doi: 10.1016/j.freeradbiomed.2026.06.060. Online ahead of print. ABSTRACT Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly. Its pathogenesis remains incompletely understood, partly due to the complex interplay of genetic risk, aging, and environmental stressors. Cigarette smoking (CS) is a major modifiable risk factor for […]
Concurrence of Inherited Nuclear and Mitochondrial DNA Optic Neuropathies
J Neuroophthalmol. 2026 Jul 2. doi: 10.1097/WNO.0000000000002466. Online ahead of print. NO ABSTRACT PMID:42384543 | DOI:10.1097/WNO.0000000000002466
Regulation of SARM1 on SNPH expression and its participation in glaucomatous optic neuropathy
Zhonghua Yan Ke Za Zhi. 2026 Jul 11;62(7):520-527. doi: 10.3760/cma.j.cn112142-20251106-00463. ABSTRACT Objective: To investigate the molecular mechanism of toll-like receptor adaptor protein SARM1 in glaucomatous optic neuropathy. Methods: The experimental study was conducted from February 2024 to October 2025. A chronic ocular hypertension glaucoma model was established by injecting micro-magnetic beads into the anterior chamber […]