RETHINKING AEROBIC METABOLISM IN RETINAL ROD OUTER SEGMENTS: TRIPLE METABOLIC HYPOTHESIS AND CLINICAL IMPLICATIONS
Prog Retin Eye Res. 2026 Aug 21:101513. doi: 10.1016/j.preteyeres.2026.101513. Online ahead of print. ABSTRACT The vertebrate retina is among the most energy-demanding tissues in the body, with photoreceptors accounting for most of its metabolic activity. The photoreceptor outer segment, devoid of mitochondria, carries out visual transduction. Oxidative phosphorylation in the rod inner segment has been […]
Dysfunction of the Neurovascular Unit in Diabetic Retinopathy: Advances from Molecular Mechanisms to Targeted Interventions
Stem Cell Rev Rep. 2026 Aug 20. doi: 10.1007/s12015-026-11213-6. Online ahead of print. ABSTRACT Diabetic retinopathy (DR) is a leading cause of vision loss and is now increasingly understood as a neurovascular disease rather than a purely microvascular complication of diabetes. The retinal neurovascular unit (NVU), composed of neurons, Müller cells, microglia, astrocytes, endothelial cells, […]
Novel Variants in Mitochondrial Ribosomal RNA Genes MT-RNR1 and MT-RNR2 Identified in Hereditary Optic Neuropathy Initially Presenting as Normal Tension Glaucoma: A Case Report
Case Rep Ophthalmol. 2026 Jul 15;17(1):853-859. doi: 10.1159/000553606. eCollection 2026 Jan-Dec. ABSTRACT INTRODUCTION: Hereditary optic neuropathy may be caused by various mitochondrial or nuclear DNA mutations affecting the mitochondrial function. A growing body of evidence shows that mutations in non-classical mitochondrial genes, including the ribosomal RNA genes MT-RNR1 and MT-RNR2, have been reported in patients […]
Advancing Treatment of Degenerative Eye Diseases at the Nanoscale
Smart Med. 2026 Aug 12;5(4):e70050. doi: 10.1002/smmd.70050. eCollection 2026 Aug. ABSTRACT Degenerative ocular diseases are characterized by a convergence of molecular perturbations, including oxidative stress, chronic inflammation, failure of proteostasis, mitochondrial dysfunction, abnormal angiogenic signaling, and biomechanical remodeling. The eye’s unique architecture, sealed by the blood-retina barrier, presents formidable anatomical and cellular topological challenges to […]
Zhuhuang granules inhibit HIF-1alpha signaling to regulate oxidative stress-mitochondrial function axis to improve psoriasis
Tissue Cell. 2026 Aug 13;104(Pt 1):103861. doi: 10.1016/j.tice.2026.103861. Online ahead of print. ABSTRACT Psoriasis is a chronic immune-mediated skin disorder characterized by keratinocyte hyperproliferation and persistent inflammation. This study evaluated the therapeutic effects of Zhuhuang granules and investigated their underlying mechanism. Ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS), network pharmacology, and molecular docking were combined with […]
Dual-Action Cationic Nanoparticle Eye Drops Synergistically Disrupt the Pathological Cycle of Dry Eye Disease via ROS-Scavenging and Inflammation Inhibition
ACS Appl Mater Interfaces. 2026 Aug 20. doi: 10.1021/acsami.6c13824. Online ahead of print. ABSTRACT Dry eye disease (DED) is an increasingly prevalent ocular surface disorder that causes discomfort and, in severe cases, visual impairment. A central feature of DED is a self-perpetuating oxidative stress-inflammation cycle, in which excessive reactive oxygen species (ROS) production initiates and […]
New mitogenomic evidence for the phylogeny of Siphonaptera: insights from Callopsylla dolabris and Oropsylla silantiewi
Front Vet Sci. 2026 Aug 4;13:1876060. doi: 10.3389/fvets.2026.1876060. eCollection 2026. ABSTRACT As important vectors of infectious diseases such as plague, fleas require accurate classification and phylogenetic analysis, which are essential for public health prevention and control. However, complete mitochondrial genome resources for Siphonaptera in public databases are still extremely scarce. In this study, the complete […]
Exploring the effect of red and near-infrared light on neurodegenerative disease: A focus on amyotrophic lateral sclerosis, Charcot’s devastating disease of the motor system
Int Rev Neurobiol. 2026;189:205-236. doi: 10.1016/bs.irn.2026.01.013. Epub 2026 Feb 9. ABSTRACT All neurodegenerative diseases, from Alzheimer’s disease to amyotrophic lateral sclerosis (ALS), are characterised by a relentless and progressive degeneration of neurones. The degenerating neurones suffer from mitochondrial dysfunction, glutamate excitotoxicity, metabolic disorder and atypical protein aggregations; there is also widespread neuroinflammation and damage to […]
Late-onset Leber Hereditary Optic Neuropathy: disease triggers and prognostic factors in a large Italian cohort
Ophthalmology. 2026 Aug 18:S0161-6420(26)00586-5. doi: 10.1016/j.ophtha.2026.08.017. Online ahead of print. ABSTRACT PURPOSE: To characterize the clinical and genetic features, investigate disease triggers, and explore factors associated with visual recovery in late-onset Leber Hereditary Optic Neuropathy (LHON). DESIGN: Retrospective cohort study. SUBJECTS, PARTICIPANTS, AND/OR CONTROLS: Seventy-seven patients with late-onset LHON (onset ≥ 40 years of age) […]
Hierarchical ROS-scavenging hydrogel system for coordinating the modulation of RGC necroptosis and oxidative stress in an acute glaucoma model
Bioact Mater. 2026 Aug 7;66:1252-1271. doi: 10.1016/j.bioactmat.2026.07.012. eCollection 2026 Dec. ABSTRACT Glaucoma, a leading cause of irreversible blindness, is characterized by the progressive loss of retinal ganglion cells (RGCs). Beyond intraocular pressure (IOP)-dependent injury, IOP-independent pathways, specifically the self-amplifying axis between oxidative stress and the necroptotic cascade, are key drivers of disease progression. Mediated by […]