Ocular IL-1alpha/IFN-gamma Delay the Corneal Wound Healing in Rheumatoid Arthritis Through Mitochondrial Dysfunction and NLRP3 Inflammasome Activation
Invest Ophthalmol Vis Sci. 2026 Jul 1;67(8):27. doi: 10.1167/iovs.67.8.27. ABSTRACT PURPOSE: Rheumatoid arthritis (RA) is an autoimmune disease often associated with corneal ulceration and impaired corneal epithelial wound healing (CEWH), although the underlying cause remains unclear. This study aims to elucidate the pathogenic mechanism of RA-associated delayed CEWH. METHODS: We integrated analyses of human clinical […]
The first complete mitochondrial genome sequences of Neopsylla specialis dechingensis and Neopsylla stevensi sichuanyunnana, with an assessment of their phylogenetic placement
Front Vet Sci. 2026 Jun 23;13:1865746. doi: 10.3389/fvets.2026.1865746. eCollection 2026. ABSTRACT Fleas are common blood-sucking external parasites found on mammals; they serve as important vectors for various pathogenic microorganisms and pose a serious threat to human and animal health. Mitochondrial genomes have been widely used in studies such as DNA barcoding for species identification and […]
Attenuating Ischemia and Reperfusion Injury Using NAD+-Loaded Nanoparticles in Mouse Kidneys
Transplant Direct. 2025 Dec 12;12(1):e1890. doi: 10.1097/TXD.0000000000001890. eCollection 2026 Jan. ABSTRACT BACKGROUND: Ischemia and reperfusion (IR) injury is a major complication in solid organ transplantation, necessitating new therapeutic strategies to suppress IR injury and thereby reduce early allograft dysfunction and delayed graft function. In kidney transplantation, IR injury is associated with disruption of mitochondrial homeostasis, […]
Modified Hotz Operation Combined with Modified Medial Canthoplasty to Correct Congenital Lower Eyelid Epiblepharon in a Chinese Population
Aesthetic Plast Surg. 2026 Jul 7. doi: 10.1007/s00266-026-06018-4. Online ahead of print. ABSTRACT BACKGROUND: Epiblepharon correction combined with epicanthoplasty is useful for the treatment of congenital lower eyelid epiblepharon (CE). To further refine this approach, we developed a modified medial canthoplasty (Mod-MC) involving removal of the medial canthus fibrous band (MCFB), combined with a modified […]
TRPM7-mediated calcium signaling contributes to Hyperglycemia-induced mitochondrial dysfunction and apoptosis in retinal Muller cells
Cell Signal. 2026 Jul 7:112728. doi: 10.1016/j.cellsig.2026.112728. Online ahead of print. ABSTRACT Calcium signaling dysregulation is a critical trigger of mitochondrial dysfunction in metabolic disorders, yet the upstream mechanisms linking hyperglycemic stress to organellar Ca2+ overload remain poorly defined. The transient receptor potential melastatin 7 (TRPM7) channel functions as a Ca2+-permeable signaling node with unique […]
Endosymbiotic theory of aging revisited: Age-related leakage of mitochondrial dsDNA/RNA stimulates cytosolic nucleic acid sensors which remodel the immune network and promote the aging process
Biogerontology. 2026 Jul 7;27(4):124. doi: 10.1007/s10522-026-10470-9. ABSTRACT About 1.5-2 billion years ago, an endosymbiosis between aerobic α-proteobacteria and anaerobic archaeal cells generated mitochondria, i.e., organelles capable of producing oxidative energy. The bacterial genome was fundamentally reduced and a circular mitochondrial genome evolved containing mainly the genes coding for the subunits of the electron transport chain. […]
Enhanced Endocytosis and Mitochondrial Stress Underlie Severe Retinitis Pigmentosa With RHO P347L Mutant
Invest Ophthalmol Vis Sci. 2026 Jul 1;67(8):23. doi: 10.1167/iovs.67.8.23. ABSTRACT PURPOSE: RHO mutations are the primary cause of autosomal dominant retinitis pigmentosa (adRP), with Class 1 mutations typically exhibiting more severe phenotypes than Class 2. This study aims to clarify the mechanistic basis for this clinical disparity by systematically comparing protein degradation pathways, mitochondrial stress, […]
TRPM7 Channel-Mediated Mitochondrial Oxidative Stress Induces Dysfunction of Muller Cells Under High Glucose and Low Mg(2+) Stress
Front Biosci (Landmark Ed). 2026 Jun 8;31(6):50306. doi: 10.31083/FBL50306. ABSTRACT BACKGROUND: Clinical epidemiological data have shown that hypomagnesemia, defined as a serum Mg2+ concentration of <0.7 mmol/L, independently increases the risk of diabetic retinopathy (DR) in patients with type 2 diabetes mellitus (T2DM). The molecular and cellular mechanisms through which hypomagnesemia accelerates the onset and […]
Dual-Hit Myopia Mechanism Unveiled by Multi-Omics: Opn1mw Deficiency Primed the Retina for Exaggerated Response to Environmental Defocus
Invest Ophthalmol Vis Sci. 2026 Jul 1;67(8):11. doi: 10.1167/iovs.67.8.11. ABSTRACT PURPOSE: Chromatic cues have long been implicated in refractive development, and OPN1MW variants are strongly associated with high myopia in humans. This study aimed to elucidate how cone opsin dysfunction translates into molecular and functional susceptibility to myopia. METHODS: Retinal transcriptome and metabolome sequencing were […]
The Molecular Basis of Ocular Aging: Mechanisms, Pathologies, and Emerging Therapeutics
Invest Ophthalmol Vis Sci. 2026 Jul 1;67(8):13. doi: 10.1167/iovs.67.8.13. ABSTRACT Age-related eye diseases (AREDs)-including age-related macular degeneration (AMD), glaucoma, and diabetic retinopathy-are leading causes of permanent blindness. Current treatments manage clinical manifestations but do not halt the molecular processes that drive disease progression. This limitation has shifted attention toward “geroscience,” a strategy that targets the […]