AARS2-Related Disorder
2024 Oct 31. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024. ABSTRACT CLINICAL CHARACTERISTICS: AARS2-related disorder includes two distinct phenotypes, infantile-onset cardiomyopathy and neurodegeneration with or without leukoencephalopathy. AARS2-related infantile-onset cardiomyopathy is characterized by hypertrophic cardiomyopathy, hypotonia, skeletal myopathy, and […]
Hexokinase 2 senses fructose in tumor-associated macrophages to promote colorectal cancer growth
Cell Metab. 2024 Oct 24:S1550-4131(24)00398-X. doi: 10.1016/j.cmet.2024.10.002. Online ahead of print. ABSTRACT Fructose is associated with colorectal cancer tumorigenesis and metastasis through ketohexokinase-mediated metabolism in the colorectal epithelium, yet its role in the tumor immune microenvironment remains largely unknown. Here, we show that a modest amount of fructose, without affecting obesity and associated complications, promotes […]
Corrigendum: Cytosolic protein translation regulates cell asymmetry and function in early TCR activation of human CD8+ T lymphocytes
Front Immunol. 2024 Oct 14;15:1500666. doi: 10.3389/fimmu.2024.1500666. eCollection 2024. ABSTRACT [This corrects the article DOI: 10.3389/fimmu.2024.1411957.]. PMID:39469710 | PMC:PMC11513589 | DOI:10.3389/fimmu.2024.1500666
Retinal G-protein-coupled receptor deletion exacerbates AMD-like changes via the PINK1-parkin pathway under oxidative stress
FASEB J. 2024 Oct;38(20):e70135. doi: 10.1096/fj.202401160RR. ABSTRACT The intake of high dietary fat has been correlated with the progression of age-related macular degeneration (AMD), affecting the function of the retinal pigment epithelium through oxidative stress. A high-fat diet (HFD) can lead to lipid metabolism disorders, excessive production of circulating free fatty acids, and systemic inflammation […]
Ion Channel Piezo1 Induces Ferroptosis of Trabecular Meshwork Cells: A Novel Observation in the Pathogenesis in Primary Open Angle Glaucoma
Am J Physiol Cell Physiol. 2024 Oct 28. doi: 10.1152/ajpcell.00173.2024. Online ahead of print. ABSTRACT PURPOSE: This study aims to elucidate the role of Piezo1, a mechanosensitive molecule, in trabecular meshwork cells (TMCs) in the context of Primary Open Angle Glaucoma (POAG), a leading cause of irreversible visual impairment. Dysfunction of the trabecular meshwork (TM) […]
Prognostic Prediction and Immune Microenvironment Characterization in Uveal Melanoma: A Novel Mitochondrial Metabolism-Related Gene Signature
ACS Omega. 2024 Oct 10;9(42):43034-43045. doi: 10.1021/acsomega.4c06294. eCollection 2024 Oct 22. ABSTRACT Uveal Melanoma (UM), a highly aggressive and metastatic intraocular cancer with a strong propensity for liver metastasis, presents limited therapeutic alternatives and unfavorable survival outcomes. Despite its low incidence, the underlying mechanisms of UM pathogenesis and the precise role of mitochondrial metabolism in […]
Oxidative Stress in Cataract Formation: Is There a Treatment Approach on the Horizon?
Antioxidants (Basel). 2024 Oct 16;13(10):1249. doi: 10.3390/antiox13101249. ABSTRACT Cataracts, a leading cause of blindness worldwide, are closely linked to oxidative stress-induced damage to lens epithelial cells (LECs). Key factors contributing to cataract formation include aging, arterial hypertension, and diabetes mellitus. Given the high global prevalence of cataracts, the burden of cataract-related visual impairment is substantial, […]
Prevention of Sunlight-Induced Cell Damage by Selective Blue-Violet-Light-Filtering Lenses in A2E-Loaded Retinal Pigment Epithelial Cells
Antioxidants (Basel). 2024 Oct 1;13(10):1195. doi: 10.3390/antiox13101195. ABSTRACT Blue light accelerates retinal aging. Previous studies have indicated that wavelengths between 400 and 455 nm are most harmful to aging retinal pigment epithelia (RPE). This study explored whether filtering these wavelengths can protect cells exposed to broad sunlight. Primary porcine RPE cells loaded with 20 µM […]
Unexpected and Synergistical Effects of All-Trans Retinoic Acid and TGF-β2 on Biological Aspects of 2D and 3D Cultured ARPE19 Cells
Biomedicines. 2024 Sep 30;12(10):2228. doi: 10.3390/biomedicines12102228. ABSTRACT Objectives: To study the effects of all-trans retinoic acid (ATRA) on TGF-β2-induced effects of human retinal pigment epithelium cells under normoxia and hypoxia conditions. Methods: Two-dimensionally (2D) and three-dimensionally (3D) cultured ARPE19 cells were subjected to cellular functional analyses by transepithelial electrical resistance (TEER) and an extracellular flux […]
AIBP Protects Muller Glial Cells Against Oxidative Stress-Induced Mitochondrial Dysfunction and Reduces Retinal Neuroinflammation
Antioxidants (Basel). 2024 Oct 17;13(10):1252. doi: 10.3390/antiox13101252. ABSTRACT Glaucoma, an optic neuropathy with the loss of retinal ganglion cells (RGCs), is a leading cause of irreversible vision loss. Oxidative stress and mitochondrial dysfunction have a significant role in triggering glia-driven neuroinflammation and subsequent glaucomatous RGC degeneration in the context of glaucoma. It has previously been […]