Acute High Intraocular Pressure Induced by Vitreous Cavity Infusion: an animal model to evaluate corneal endothelial injuries
Exp Eye Res. 2025 Nov 20:110765. doi: 10.1016/j.exer.2025.110765. Online ahead of print. ABSTRACT Elevated intraocular pressure (IOP) is a critical factor in corneal endothelial cells (CECs) injury, yet the precise mechanisms remain poorly understood due to confounding variables in clinical studies. This study developed an acute high IOP model in New Zealand rabbits by vitreous […]
First record of Argulus japonicus infestation on Cyprinus carpio in Hungary, and the first description of Argulus japonicus europaeus subsp. nov. Keve, 2025
Parasit Vectors. 2025 Nov 21;18(1):480. doi: 10.1186/s13071-025-07106-1. ABSTRACT BACKGROUND: Species belonging to the genus Argulus are globally distributed fish parasites. Their veterinary significance primarily lies in their disruptive presence and their role as mechanical vectors. Although Argulus japonicus Thiele, 1900 is a widely distributed representative of this genus that feeds on freshwater fish, only Argulus […]
Amniotic membrane transplantation promotes retinal hole closure in a rabbit model
Sci Rep. 2025 Nov 21;15(1):41253. doi: 10.1038/s41598-025-25162-6. ABSTRACT Amniotic membrane transplantation (AMT) is an effective treatment for refractory macular hole closure, yet the underlying mechanism supporting that effectiveness remains unclear. Here, we investigated the role of retinal regeneration in this process using an in vivo rabbit retinal-hole (RH) model in which AMT was performed on […]
RAB3GAP2 silencing alleviates oxidative stress in cataracts by enhancing Mfn2-mediated mitochondrial autophagy by activating JNK/STAT3
Int J Biol Macromol. 2025 Nov 19:149102. doi: 10.1016/j.ijbiomac.2025.149102. Online ahead of print. ABSTRACT Cataracts seriously affect the vision of patients and can even lead to blindness. RAB3GAP2 is associated with cataracts, but its regulatory effects on cataracts need to be determined. We established a mouse model of cataracts and cell models of cataracts induced […]
IT TAKES TWO TO TANGO: potential novel therapies for autosomal dominant optic atrophy
Front Ophthalmol (Lausanne). 2025 Nov 5;5:1688232. doi: 10.3389/fopht.2025.1688232. eCollection 2025. ABSTRACT Autosomal dominant optic atrophy (ADOA) is among the most prevalent inherited optic neuropathies with hallmark symptoms of bilateral, painless, progressive, and typically permanent vision loss over time. ADOA can affect patients’ quality of life with debilitating visual symptoms, and there is a pressing need […]
3-Hydroxyisobutyryl-CoA Hydrolase Deficiency
2025 Nov 20. In: Adam MP, Bick S, Mirzaa GM, Pagon RA, Wallace SE, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2025. ABSTRACT CLINICAL CHARACTERISTICS: 3-Hydroxyisobutyryl-CoA hydrolase (HIBCH) deficiency can be categorized into three subtypes based on age of presentation. Neonatal onset, the least frequent phenotype, is characterized by hypotonia, seizures, […]
Kenny mediates the recruitment of the phagophore for ubiquitin-dependent mitophagy in Drosophila neurons
Mol Biol Cell. 2025 Nov 19:mbcE25050235. doi: 10.1091/mbc.E25-05-0235. Online ahead of print. ABSTRACT The maintenance of healthy mitochondria is essential to neuronal homeostasis. Mitophagy is a critical mechanism that degrades damaged mitochondria, and disruption of this process is associated with neurodegenerative disease. Previous work has shown that mammalian optineurin (OPTN), a gene mutated in familial […]
Protective effects of luteolin on high glucose-induced ferroptosis in müller cells
Int Ophthalmol. 2025 Nov 19;45(1):494. doi: 10.1007/s10792-025-03850-6. ABSTRACT PURPOSE: This study aims to investigate the protective effects of luteolin on Müller cells under high glucose conditions and to elucidate its potential mechanisms of action. METHODS: Firstly, Primary rat retinal Müller cells were divided into three groups: a control group (Control), a high glucose group (HG), […]
Impact of the Warburg effect on nucleotide homeostasis in human retinal endothelial cells and its relevance to proliferative diabetic retinopathy
Front Pharmacol. 2025 Nov 3;16:1660067. doi: 10.3389/fphar.2025.1660067. eCollection 2025. ABSTRACT PURPOSE: While great progress has been made in screening methods and therapies for proliferative diabetic retinopathy (PDR), it is still a major cause of blindness. Rapidly dividing cells reprogram their metabolism toward hyperglycolysis (the Warburg effect), a process recently implicated in angiogenesis. In this study, […]
Pathogenic mechanisms of Leber hereditary optic neuropathy caused by m.3472T>C mutation
Zhejiang Da Xue Xue Bao Yi Xue Ban. 2025 Nov 12:1-11. doi: 10.3724/zdxbyxb-2025-0241. Online ahead of print. ABSTRACT OBJECTIVES: To investigate the molecular mechanism underlying Leber hereditary optic neuropathy (LHON) caused by the m.3472T>C (p.Phe56Leu) mutation. METHODS: From a cohort of 1397 LHON patients, three large pedigrees (WZL122, WZ676, WZ706) carrying the m.3472T>C mutation were […]