Short-term high-dose nicotinamide treatment across glaucoma subtypes reveals increased mtDNA content and minimal metabolomic change in blood
Exp Eye Res. 2025 Dec 16:110807. doi: 10.1016/j.exer.2025.110807. Online ahead of print. ABSTRACT In glaucoma, retinal ganglion cell degeneration has been linked to declining mitochondrial metabolic capacity. Nicotinamide (NAM) supplementation has emerged as a potential treatment for this. We assessed the effects of a 2-week NAM supplementation on blood buffy coat mitochondrial content (qPCR to […]
Ezetimibe attenuates diabetic retinopathy via NRF2-mediated suppression of inflammation and oxidative stress
J Diabetes Complications. 2025 Dec 13;40(2):109250. doi: 10.1016/j.jdiacomp.2025.109250. Online ahead of print. ABSTRACT BACKGROUND: Diabetic retinopathy (DR) is a leading cause of blindness in working-age adults, driven by chronic inflammation and oxidative stress. Ezetimibe (EZE), a lipid-lowering agent, has been shown to activate the NRF2 pathway, but its role in DR remains unexplored. Our study […]
Long-acting fenofibrate-loaded microparticles for treating retinal disorders
Int J Pharm. 2025 Dec 15:126503. doi: 10.1016/j.ijpharm.2025.126503. Online ahead of print. ABSTRACT Age-related macular degeneration (AMD) and Diabetic retinopathy (DR) are the most common forms of retinal disorders and are the leading causes of vision loss. Traditional treatments such as anti-VEGF therapies often require repeated intravitreal injections. Up to 40 % DR/AMD patients do […]
Association between serum carotenoid concentrations and risk of major age-related eye diseases among middle-aged and older adults
Front Med (Lausanne). 2025 Dec 1;12:1596799. doi: 10.3389/fmed.2025.1596799. eCollection 2025. ABSTRACT BACKGROUND: Age-related eye diseases are the main causes of progressive and irreversible vision loss in aging populations worldwide. Carotenoids, as a group of common natural antioxidants, can suppress free radicals produced by complex physiological reactions, thereby protecting the eyes from the effects of oxidative […]
Single Cell RNAseq Analysis of Thyroid Hormone Effects on Retinal Glial Cells
Aging Dis. 2025 Dec 15. doi: 10.14336/AD.2025.1221. Online ahead of print. ABSTRACT Thyroid hormone (TH) signaling regulates cellular metabolism and stress response in the retina. Increased TH levels in circulation are associated with a higher incidence of age-related macular degeneration. Furthermore, stimulation of TH signaling induces retinal degeneration in mice, which is accompanied by the […]
Full recovery of vision following early and intensive hemodialysis in an 18-year-old woman with methylmalonic acidemia-related optic neuropathy
Mol Genet Metab Rep. 2025 Nov 27;45:101279. doi: 10.1016/j.ymgmr.2025.101279. eCollection 2025 Dec. ABSTRACT BACKGROUND: Methylmalonic acidemia (MMA) caused by complete or partial deficiency of the mitochondrial enzyme methylmalonyl-CoA mutase (mut0 or mut- enzymatic subtype, respectively) leads to the accumulation of toxic organic acids, causing severe organ dysfunction and life-threatening complications. Despite appropriate treatment, optic neuropathy […]
Endothelial mitochondrial-derived vesicles (EMDVs) with retinal targeted homing properties dynamically modulate the eIF2alpha-ATF4-CHOP signaling pathway and efficiently restore mitochondrial homeostasis in diabetic retina
J Nanobiotechnology. 2025 Dec 14. doi: 10.1186/s12951-025-03929-3. Online ahead of print. NO ABSTRACT PMID:41392137 | DOI:10.1186/s12951-025-03929-3
Melatonin alleviates atherosclerosis by inhibiting pro-inflammatory differentiation of macrophages via regulating Sirt3-Drp1 mediated mitochondrial fission
Int Immunopharmacol. 2025 Dec 12;169:116019. doi: 10.1016/j.intimp.2025.116019. Online ahead of print. ABSTRACT BACKGROUND: Pro-inflammatory macrophage function is linked to an increase in mitochondrial fission. Melatonin has a positive impact on atherosclerosis and has a significant effect on the control of mitochondrial fission and fusion. Nevertheless, it is still unclear how melatonin contributes to slowing the […]
Retinal Ganglion Cell Diversity in Disease: Clinical Implications and Type-Specific Evaluation
J Neuroophthalmol. 2025 Sep 1;45(3):350-361. doi: 10.1097/WNO.0000000000002381. ABSTRACT BACKGROUND: Retinal ganglion cells (RGCs) are diverse. Various types play specialized roles in vision, and they may be differentially susceptible in optic nerve disease where their death causes vision loss. RGCs are accordingly compelling targets for novel therapeutic strategies, and so it is clinically imperative to be […]
Honokiol (HNK) accelerates corneal epithelial wound healing by promoting HMGCS2-mediated mitochondrial metabolic homeostasis
Exp Eye Res. 2025 Dec 9:110805. doi: 10.1016/j.exer.2025.110805. Online ahead of print. ABSTRACT Corneal epithelial regeneration is critical for restoring ocular surface function after injury. This study investigated the therapeutic potential and molecular mechanism of honokiol (HNK) in promoting corneal epithelial repair. Using a murine corneal epithelial debridement model, we observed that HNK accelerated wound […]