Oxidative Stress in Diabetic Retinopathy: A Comprehensive Review of Mechanisms, Biomarkers, and Therapeutic Perspectives
Antioxidants (Basel). 2025 Oct 4;14(10):1204. doi: 10.3390/antiox14101204. ABSTRACT Diabetic retinopathy (DR) is a leading cause of vision loss globally and represents one of the most common microvascular complications of diabetes. In addition to metabolic disturbances associated with hyperglycemia, oxidative stress has emerged as a critical contributor to the onset and progression of DR. Oxidative stress, […]
An intraocular lens coated with polycaprolactone and methotrexate as a slow-release system for prophylaxis of posterior capsule opacification in-vitro
Biomed Pharmacother. 2025 Oct 27;192:118693. doi: 10.1016/j.biopha.2025.118693. Online ahead of print. ABSTRACT PURPOSE: Posterior capsule opacification (PCO) is the most common postoperative complication after cataract surgery. As a pharmacological prophylaxis, we designed a drug-carrying slow-release intraocular lens (IOL) implant coated with polycaprolactone and methotrexate and characterized the release kinetics and the in-vitro effect. METHODS: Electron […]
The Neuro-Ophthalmologic Manifestations of SPG7-Associated Disease
J Pers Med. 2025 Oct 16;15(10):495. doi: 10.3390/jpm15100495. ABSTRACT The gene SPG7 codes for the protein paraplegin, a subunit of the m-AAA protease in the inner mitochondrial membrane involved in protein quality control. SPG7 was initially identified as causing autosomal recessive hereditary spastic paraplegia (HSP), with a pure (insidiously progressive bilateral leg weakness and spasticity) […]
Deficiency of 2-Oxoglutarate Carrier (Slc25a11) Drives RPE Epithelial-to-Mesenchymal Transition and Exacerbates Subretinal Fibrosis in Neovascular Age-Related Macular Degeneration
Aging Cell. 2025 Oct 28:e70271. doi: 10.1111/acel.70271. Online ahead of print. ABSTRACT Subretinal fibrosis significantly contributes to vision loss in neovascular age-related macular degeneration (nAMD). Epithelial-to-mesenchymal transition (EMT) in RPE cells is a key early step in subretinal fibrosis. While mitochondrial dysfunction in RPE is involved, the metabolic and molecular connections between EMT and mitochondria […]
Light-evoked activity and BDNF regulate mitochondrial dynamics and mitochondrial localized translation in CNS axons
iScience. 2025 Sep 15;28(10):113563. doi: 10.1016/j.isci.2025.113563. eCollection 2025 Oct 17. ABSTRACT Mitochondria coordinate well-described maintenance functions within neuronal axons and dendrites. However, less is known about how mitochondria are regulated during axon development and maturation. Here, we demonstrate that within the developing visual system, retinal ganglion cell (RGC) axons in the retina and optic nerve […]
Necrotic cell death through sodium overload provides a potential mechanism against neurodegenerative diseases
Environ Pollut. 2025 Oct 23:127308. doi: 10.1016/j.envpol.2025.127308. Online ahead of print. NO ABSTRACT PMID:41138844 | DOI:10.1016/j.envpol.2025.127308
Development of an AAV-Based Gene Therapy for the Ocular Phenotype of Friedreich’s Ataxia
Mol Ther. 2025 Oct 23:S1525-0016(25)00869-X. doi: 10.1016/j.ymthe.2025.10.048. Online ahead of print. ABSTRACT Friedreich’s Ataxia (FA) is a leading form of hereditary ataxia caused by autosomal recessive mutations in frataxin (FXN). GAA triplet repeat expansions lead to lower levels of FXN expression, abnormal influx of iron into mitochondria and damage to the nervous system. Patients typically […]
Advances in eye-brain axis: anatomy, immunity, and association with visual dysfunction
Ageing Res Rev. 2025 Oct 22:102925. doi: 10.1016/j.arr.2025.102925. Online ahead of print. ABSTRACT The “eye-brain axis” refers to the dynamic system of interactions between the eyes and the brain, collectively encompassing the visual signal transmission and integration pathways. The eyes and the brain exhibit structural and functional synergy, and visual dysfunction not only impairs information […]
Sappanone A alleviates high glucose-induced retinal oxidative injury and mitochondrial dysfunction via SIRT7/NRF2 pathway
J Ethnopharmacol. 2025 Oct 22:120774. doi: 10.1016/j.jep.2025.120774. Online ahead of print. ABSTRACT ETHNOPHARMACOLOGICAL RELEVANCE: Diabetic retinopathy (DR) is a major microvascular complication of diabetes characterized by oxidative stress, mitochondrial dysfunction, and inflammation. Sappanone A (SA), a natural flavonoid derived from Caesalpinia sappan, is known for its antioxidant activity, but its ocular pharmacological potential and underlying […]
Transcriptomic profiling reveals neural-immune-stromal dysregulation and risk-associated gene signatures in advanced keratoconus
Sci Rep. 2025 Oct 24;15(1):37262. doi: 10.1038/s41598-025-21254-5. ABSTRACT This study aimed to characterize transcriptomic alterations and the effects of demographic and behavioral risk factors on disease-associated gene expression patterns in late-stage keratoconus (KC). Corneal stromal tissues from 31 KC patients and four normal donors underwent bulk RNA sequencing. Differentially expressed genes (DEGs) and weighted gene […]