Anaphylatoxin C5a receptor signaling induces mitochondrial fusion and sensitizes retina pigment epithelial cells to oxidative stress
Biochim Biophys Acta Gen Subj. 2023 May 13:130374. doi: 10.1016/j.bbagen.2023.130374. Online ahead of print. ABSTRACT Mitochondrial dynamics is a morphological balance between fragmented and elongated shapes, reflecting mitochondrial metabolic status, cellular damage, and mitochondrial dysfunction. The anaphylatoxin C5a derived from complement component 5 cleavage, enhances cellular responses involved in pathological stimulation, innate immune responses, and […]
Mitochondria and the eye-manifestations of mitochondrial diseases and their management
Eye (Lond). 2023 Apr 25. doi: 10.1038/s41433-023-02523-x. Online ahead of print. ABSTRACT Historically, distinct mitochondrial syndromes were recognised clinically by their ocular features. Due to their predilection for metabolically active tissue, mitochondrial diseases frequently involve the eye, resulting in a range of ophthalmic manifestations including progressive external ophthalmoplegia, retinopathy and optic neuropathy, as well as […]
lncRNA TUG1 regulates Smac/DIABLO expression by competitively inhibiting miR-29b and modulates the apoptosis of lens epithelial cells in age-related cataracts
Chin Med J (Engl). 2023 Apr 26. doi: 10.1097/CM9.0000000000002530. Online ahead of print. ABSTRACT BACKGROUND: As one of the early discovered long non-coding RNAs (lncRNA), taurine upregulation gene 1 (TUG1) has been widely expressed in a variety of tumors. Moreover, it promotes cell proliferation, differentiation, apoptosis, and migration. However, our understanding of its importance in […]
Wolfram syndrome: new pathophysiological insights and therapeutic strategies
Ther Adv Rare Dis. 2021 Aug 16;2:26330040211039518. doi: 10.1177/26330040211039518. eCollection 2021 Jan-Dec. ABSTRACT Wolfram Syndrome (WS) is an ultra-rare, progressive neurodegenerative disease characterized by early-onset diabetes mellitus and irreversible loss of vision, secondary to optic nerve degeneration. Visual loss in WS is an important cause of registrable blindness in children and young adults and the […]
Mitochondrial Quality Control and Metabolic Memory Phenomenon Associated with Continued Progression of Diabetic Retinopathy
Int J Mol Sci. 2023 Apr 29;24(9):8076. doi: 10.3390/ijms24098076. ABSTRACT Diabetic retinopathy continues to progress even when hyperglycemia is terminated, suggesting a ‘metabolic memory’ phenomenon. Mitochondrial dysfunction is closely associated with the development of diabetic retinopathy, and mitochondria remain dysfunctional. Quality control of mitochondria requires a fine balance between mitochondrial fission-fusion, removal of the damaged […]
Tunneling nanotubes-based intercellular mitochondrial trafficking as a novel therapeutic target in dry eye
Exp Eye Res. 2023 May 9:109497. doi: 10.1016/j.exer.2023.109497. Online ahead of print. ABSTRACT Cell-to-cell mitochondria transfer via tunneling nanotubes (TNTs) has recently been revealed as a spontaneous way to protect damaged cells. Previously, we have reported mesenchymal stem cells (MSCs) can rescue retinal ganglion cell and corneal epithelium through intercellular mitochondrial trafficking. Mitochondrial damage and […]
Effect of PPARγ on oxidative stress in diabetes-related dry eye
Exp Eye Res. 2023 May 9:109498. doi: 10.1016/j.exer.2023.109498. Online ahead of print. ABSTRACT Oxidative stress is closely associated with diabetes and can cause free radical accumulation and eventually lead to ocular surface tissue damage. The purpose of this study was to investigate peroxisome proliferator-activated receptor-γ (PPARγ) expression in the lacrimal gland (LG), meibomian gland, and […]
Dysregulation of DNA repair genes in Fuchs endothelial corneal dystrophy
Exp Eye Res. 2023 May 9:109499. doi: 10.1016/j.exer.2023.109499. Online ahead of print. ABSTRACT Fuchs Endothelial Corneal Dystrophy (FECD), a late-onset oxidative stress disorder, is the most common cause of corneal endothelial degeneration and is genetically associated with CTG repeat expansion in TCF4. We previously reported accumulation of nuclear (nDNA) and mitochondrial (mtDNA) damage in FECD. […]
Hydrogel assisted photoreceptor delivery inhibits material transfer
Biomaterials. 2023 Apr 29;298:122140. doi: 10.1016/j.biomaterials.2023.122140. Online ahead of print. ABSTRACT Cell therapy holds tremendous promise for vision restoration; yet donor cell survival and integration continue to limit efficacy of these strategies. Transplanted photoreceptors, which mediate light sensitivity in the retina, transfer cytoplasmic components to host photoreceptors instead of integrating into the tissue. Donor cell […]
Spatiotemporal Coordination of RPE Cell Quality by Extracellular Vesicle miR-494-3p Via Competitive Interplays With SIRT3 or PTEN
Invest Ophthalmol Vis Sci. 2023 May 1;64(5):9. doi: 10.1167/iovs.64.5.9. ABSTRACT PURPOSE: To reveal the molecular mechanism underlying degeneration in human retinal pigment epithelial (hRPE) cells with dysfunctional mitochondrial homeostasis. METHODS: The expression of recently identified miR-494-3p in extracellular vesicles (EV) released from induced-pluripotential-stem-cell-derived human RPE (iPS-hRPE), during coculture with macrophages (Mps) was investigated in iPS-hRPE […]