Artesunate protects against ocular fibrosis by suppressing fibroblast activation and inducing mitochondria-dependent ferroptosis
FASEB J. 2023 Jun;37(6):e22954. doi: 10.1096/fj.202201867R. ABSTRACT Artesunate, a derivative from extracts of Artemisia annua, has recently been reported to alleviate fibrosis recently. Here, in this study, we sought to determine the anti-fibrosis effect of artesunate in rabbit glaucoma filtration surgery (GFS) model and illuminate underlying mechanisms. Our results showed that artesunate subconjunctival injection alleviated […]
GSK-3β-dependent Nrf2 antioxidant response modulates ferroptosis of lens epithelial cells in age-related cataract
Free Radic Biol Med. 2023 May 6:S0891-5849(23)00399-4. doi: 10.1016/j.freeradbiomed.2023.04.022. Online ahead of print. ABSTRACT Oxidative stress-induced lens epithelial cells (LECs) death plays a pivotal role in age-related cataract (ARC) with severe visual impairment, in which ferroptosis is gradually receiving numerous attention resulting from lipid peroxide accumulation and reactive oxygen species (ROS) overproduction. However, the essential […]
The roles of autophagy and mitophagy in corneal pathology: current knowledge and future perspectives
Front Med (Lausanne). 2023 Apr 21;10:1064938. doi: 10.3389/fmed.2023.1064938. eCollection 2023. ABSTRACT The cornea is the clear dome that covers the front portion of the globe. The primary functions of the cornea are to promote the refraction of light and to protect the eye from invading pathogens, both of which are essential for the preservation of […]
Dual leucine zipper kinase is necessary for retinal ganglion cell axonal regeneration in Xenopus laevis
PNAS Nexus. 2023 Mar 30;2(5):pgad109. doi: 10.1093/pnasnexus/pgad109. eCollection 2023 May. ABSTRACT Retinal ganglion cell (RGC) axons of the African clawed frog, Xenopus laevis, unlike those of mammals, are capable of regeneration and functional reinnervation of central brain targets following injury. Here, we describe a tadpole optic nerve crush (ONC) procedure and assessments of brain reinnervation […]
Optic atrophy in a patient with axonal Charcot-Marie-Tooth disease 2A2A due to MFN2 gene mutations
Zhonghua Yan Ke Za Zhi. 2023 May 11;59(5):408-410. doi: 10.3760/cma.j.cn112142-20220611-00289. ABSTRACT A 27-year-old male patient had progressive vision loss in both eyes, which was mainly manifested by impaired ganglion cells in the macular area, accompanied by systemic muscle atrophy in limbs. A complete mitochondrial exon gene detection was performed. The final diagnosis was bilateral optic […]
Protective effects of Scoparia dulcis L. extract on high glucose-induced injury in human retinal pigment epithelial cells
Front Nutr. 2023 Mar 30;10:1085248. doi: 10.3389/fnut.2023.1085248. eCollection 2023. ABSTRACT Diabetic retinopathy (DR) is a major cause of vision loss in diabetic patients. Hyperglycemia-induced oxidative stress and the accumulation of inflammatory factors result in blood-retinal barrier dysfunction and the pathogenesis of DR. Scoparia dulcis L. extract (SDE), a traditional Chinese medicine, has been recently recognized […]
Mitochondrial decline in the ageing old world primate retina: Little evidence for difference between the centre and periphery
PLoS One. 2023 May 2;18(5):e0273882. doi: 10.1371/journal.pone.0273882. eCollection 2023. ABSTRACT Mitochondrial decline is a key feature of ageing. The retina has more mitochondria than any other tissue and ages rapidly. To understand human retinal ageing it is critical to examine old world primates that have similar visual systems to humans, and do so across central […]
The Interplay Between Metabolites and MicroRNAs in Aqueous Humor to Coordinate Corneal Endothelium Integrity
Ophthalmol Sci. 2023 Mar 16;3(3):100299. doi: 10.1016/j.xops.2023.100299. eCollection 2023 Sep. ABSTRACT PURPOSE: The purpose of the study was to clarify the interplay between metabolites and microRNAs (miRs) in the aqueous humor (AqH) of bullous keratopathy (BK) patients to retain human corneal endothelium (HCE) integrity. DESIGN: Prospective, comparative, observational study. PARTICIPANTS: A total of 55 patients […]
iPSC-derived retinal pigmented epithelial cells from patients with macular telangiectasia show decreased mitochondrial function
J Clin Invest. 2023 May 1;133(9):e163771. doi: 10.1172/JCI163771. ABSTRACT Patient-derived induced pluripotent stem cells (iPSCs) provide a powerful tool for identifying cellular and molecular mechanisms of disease. Macular telangiectasia type 2 (MacTel) is a rare, late-onset degenerative retinal disease with an extremely heterogeneous genetic architecture, lending itself to the use of iPSCs. Whole-exome sequencing screens […]
Nordalbergin Exerts Anti-Neuroinflammatory Effects by Attenuating MAPK Signaling Pathway, NLRP3 Inflammasome Activation and ROS Production in LPS-Stimulated BV2 Microglia
Int J Mol Sci. 2023 Apr 14;24(8):7300. doi: 10.3390/ijms24087300. ABSTRACT Microglia-associated neuroinflammation is recognized as a critical factor in the pathogenesis of neurodegenerative diseases; however, there is no effective treatment for the blockage of neurodegenerative disease progression. In this study, the effect of nordalbergin, a coumarin isolated from the wood bark of Dalbergia sissoo, on […]