Autonomic instability, arrhythmia and visual impairment in a new presentation of MTFMT-related mitochondrial disease
JIMD Rep. 2022 Dec 8;64(2):150-155. doi: 10.1002/jmd2.12355. eCollection 2023 Mar. ABSTRACT Mitochondrial methionyl-tRNA formyltransferase (MTFMT) is required for the initiation of translation in mitochondria. Pathogenic variants in MTFMT have been described in association with clinical presentations with Leigh syndrome, as well with as multisystem involvement (particularly cardiac and ocular involvement). There is a spectrum of […]
Benzyl isothiocyanate improves the prognosis of Aspergillus fumigatus keratitis by reducing fungal load and inhibiting Mincle signal pathway
Front Microbiol. 2023 Feb 16;14:1119568. doi: 10.3389/fmicb.2023.1119568. eCollection 2023. ABSTRACT Aspergillus fumigatus keratitis is a potential blinding disease associated with A. fumigatus invasion and excessive inflammatory response. Benzyl isothiocyanate (BITC) is a secondary metabolite with broad antibacterial and anti-inflammatory activity extracted from cruciferous species. However, the role of BITC in A. fumigatus keratitis has not […]
Curcumin Alleviates Oxidative stress, Neuroinflammation, and Promotes Behavioral Recovery after Traumatic Brain Injury
Curr Neurovasc Res. 2023 Mar 3. doi: 10.2174/1567202620666230303144323. Online ahead of print. ABSTRACT BACKGROUND: Neuroinflammation and oxidative stress after traumatic brain injury (TBI) can further lead to neuronal apoptosis, which plays a crucial role in the process of neuron death. Curcumin, which is derived from the rhizome of the Curcuma longa plant, has multiple pharmacological […]
Cigarette smoke induces the ROS accumulation and iNOS activation through deactivation of Nrf-2/SIRT3 axis to mediate the human bronchial epithelium ferroptosis
Free Radic Biol Med. 2023 Mar 3:S0891-5849(23)00100-4. doi: 10.1016/j.freeradbiomed.2023.03.002. Online ahead of print. ABSTRACT Cigarette smoke (CS)-induced oxidative stress drives the pathogenesis of respiratory diseases, in which the activation and accumulation of reactive oxygen species (ROS) play an important role. Ferroptosis, a regulated cell death induced by Fe2+-dependent, lipid peroxidation, and ROS, is closely related […]
Multiple Bioenergy-Linked OCT Biomarkers Suggest Greater-Than-Normal Rod Mitochondria Activity Early in Experimental Alzheimer’s Disease
Invest Ophthalmol Vis Sci. 2023 Mar 1;64(3):12. doi: 10.1167/iovs.64.3.12. ABSTRACT PURPOSE: In Alzheimer’s disease, central brain neurons show evidence for early hyperactivity. It is unclear if this occurs in the retina, another disease target. Here, we tested for imaging biomarker manifestation of prodromal hyperactivity in rod mitochondria in vivo in experimental Alzheimer’s disease. METHODS: Light- […]
Diabetic retinopathy as the leading cause of blindness and early predictor of cascading complications-risks and mitigation
EPMA J. 2023 Feb 13;14(1):21-42. doi: 10.1007/s13167-023-00314-8. eCollection 2023 Mar. ABSTRACT Proliferative diabetic retinopathy (PDR) the sequel of diabetic retinopathy (DR), a frequent complication of diabetes mellitus (DM), is the leading cause of blindness in the working-age population. The current screening process for the DR risk is not sufficiently effective such that often the disease […]
Kearns-Sayre Syndrome Masquerading as Myasthenia Gravis
Retin Cases Brief Rep. 2022 Dec 22. doi: 10.1097/ICB.0000000000001397. Online ahead of print. ABSTRACT PURPOSE: Kearns-Sayre syndrome (KSS) is a mitochondrial DNA (mtDNA) deletion syndrome that is characterized by the triad of onset commonly before age twenty, pigmentary retinopathy, and chronic progressive external ophthalmoplegia. Here we present a case of KSS masquerading as myasthenia gravis […]
A case of Aicardi syndrome associated with duplication event of Xp22 including SHOX
Ophthalmic Genet. 2023 Feb 2:1-4. doi: 10.1080/13816810.2023.2172190. Online ahead of print. ABSTRACT BACKGROUND: Aicardi syndrome is a neurodevelopmental disorder characterized by a triad of partial or complete agenesis of the corpus callosum, infantile spasms, and pathognomonic chorioretinal lacunae. METHODS: Examination, multimodal imaging, and genetic testing were used to guide diagnosis. RESULTS: We report a case […]
Long-term blue light exposure impairs mitochondrial dynamics in the retina in light-induced retinal degeneration in vivo and in vitro
J Photochem Photobiol B. 2023 Mar;240:112654. doi: 10.1016/j.jphotobiol.2023.112654. Epub 2023 Jan 24. ABSTRACT Long-term light exposure, especially in the spectrum of blue light, frequently causes excessive oxidative stress in dry age-related macular degeneration (AMD). Here, to gain insight into the underlying mechanism, we focused on mitochondrial dynamics alterations under long-term exposure to blue light in […]
TiO2nanotubes induce early mitochondrial fission in BMMSCs and promote osseointegration
Biomed Mater. 2023 Feb 8;18(2). doi: 10.1088/1748-605X/acb7bc. ABSTRACT Nanotopography can promote osseointegration, but how bone marrow mesenchymal stem cells (BMMSCs) respond to this physical stimulus is unclear. Here, we found that early exposure of BMMSCs to nanotopography (6 h) caused mitochondrial fission rather than fusion, which was necessary for osseointegration. We analyzed the changes in […]