Curcumin attenuates hydroxychloroquine-mediated apoptosis and oxidative stress via the inhibition of TRPM2 channel signalling pathways in a retinal pigment epithelium cell line
Graefes Arch Clin Exp Ophthalmol. 2023 Apr 26. doi: 10.1007/s00417-023-06082-5. Online ahead of print. ABSTRACT PURPOSE: Hydroxychloroquine (HCQ) is used in the treatment of several diseases, such as malaria, Sjögren’s disease, Covid-19, and rheumatoid arthritis. However, HCQ induces retinal pigment epithelium death via the excessive increase of cytosolic (cROS) and mitochondrial (mROS) free oxygen radical […]
Fucoxanthin protects retinal ganglion cells and promotes parkin-mediated mitophagy against glutamate excitotoxicity
Neuroreport. 2023 May 3;34(7):385-394. doi: 10.1097/WNR.0000000000001902. Epub 2023 Apr 1. ABSTRACT OBJECTIVE: To clarify whether fucoxanthin plays a protective role and regulates parkin-mediated mitophagy on retinal ganglion cells (RGCs) against glutamate excitotoxicity. METHODS: The excitotoxicity model of primary RGCs was carried out with glutamate. Mitochondrial membrane potential was measured by JC-1 kit (Abcam, USA). The […]
Fucoxanthin protects retinal ganglion cells and promotes parkin-mediated mitophagy against glutamate excitotoxicity
Neuroreport. 2023 Apr 3. doi: 10.1097/WNR.0000000000001902. Online ahead of print. ABSTRACT OBJECTIVE: To clarify whether fucoxanthin plays a protective role and regulates parkin-mediated mitophagy on retinal ganglion cells (RGCs) against glutamate excitotoxicity. METHODS: The excitotoxicity model of primary RGCs was carried out with glutamate. Mitochondrial membrane potential was measured by JC-1 kit (Abcam, USA). The […]
Metabolic Intervention Liposome Boosted Lung Cancer Radio-Immunotherapy via Hypoxia Amelioration and PD-L1 Restraint
Adv Sci (Weinh). 2023 Apr 24:e2207608. doi: 10.1002/advs.202207608. Online ahead of print. ABSTRACT At present, radiotherapy (RT) still acquires limited success in clinical due to the lessened DNA damage under hypoxia and acquired immune tolerance owing to the amplified programmed death ligand-1 (PD-L1) expression. Incredibly, intracellular PD-L1 expression depression is proven to better sensitize RT […]
Central retinal artery occlusion as a result of symptomatic patent foramen ovale
Rom J Ophthalmol. 2023 Jan-Mar;67(1):69-72. doi: 10.22336/rjo.2023.12. ABSTRACT Objective: The objective of this case report is to highlight the importance of patent foramen ovale (PFO) as a potential cause of central retinal artery occlusion (CRAO). Methods: A teenage girl presented with a sudden painless onset of vision loss in the right eye, which was accompanied […]
Hyperglycemia induces tear reduction and dry eye in diabetic mice through the norepinephrine-α1AR -mitochondrial impairment axis of lacrimal gland
Am J Pathol. 2023 Apr 21:S0002-9440(23)00132-3. doi: 10.1016/j.ajpath.2023.03.015. Online ahead of print. ABSTRACT Dry eye syndrome is a common complication in diabetic patients with a prevalence of up to 54.3%. However, the pathogenic mechanisms underlying hyperglycemia-induced tear reduction and dry eye remain less understood. In the present study, we found that both norepinephrine (NE) and […]
Watching the human retina breath in real time and the slowing of mitochondrial respiration with age
Sci Rep. 2023 Apr 20;13(1):6445. doi: 10.1038/s41598-023-32897-7. ABSTRACT The retina has the greatest metabolic demand in the body particularly in dark adaptation when its sensitivity is enhanced. This requires elevated level of perfusion to sustain mitochondrial activity. However, mitochondrial performance declines with age leading to reduced adaptive ability. We assessed human retina metabolism in vivo […]
Therapeutic possibilities of stimulating reparative neurogenesis in patients with glaucoma who have recovered from a coronavirus infection
Vestn Oftalmol. 2023;139(2):44-51. doi: 10.17116/oftalma202313902144. ABSTRACT In patients with glaucoma, the neuroplasticity of retinal cells, their axons and neuroglial elements is pathogenetically reduced, including due to a decrease in the concentration of neurotrophic factors. Coronavirus infections contribute to the damage processes, causing apoptosis of retinal and optic nerve cells. In this regard, the possibility of […]
Comparison of different gene-therapy methods to treat Leber hereditary optic neuropathy in a mouse model
Front Neurosci. 2023 Mar 27;17:1119724. doi: 10.3389/fnins.2023.1119724. eCollection 2023. ABSTRACT INTRODUCTION: Therapies for Leber hereditary optic neuropathy (LHON), in common with all disorders caused by mutated mitochondrial DNA, are inadequate. We have developed two gene therapy strategies for the disease: mitochondrial-targeted and allotopic expressed and compared them in a mouse model of LHON. METHODS: A […]
The Pathological Mechanisms and Novel Therapeutics for Leber’s Hereditary Optic Neuropathy
J Chin Med Assoc. 2023 Apr 10. doi: 10.1097/JCMA.0000000000000927. Online ahead of print. ABSTRACT Optic neuropathies were estimated to affect 115 in 100,000 population in 2018. Leber’s Hereditary Optic Neuropathy (LHON) as one of such optic neuropathy diseases that was first identified in 1871 and can be defined as a hereditary mitochondrial disease. LHON is […]