Oxidative Stress-Involved Mitophagy of Retinal Pigment Epithelium and Retinal Degenerative Diseases
Cell Mol Neurobiol. 2023 Jul 1. doi: 10.1007/s10571-023-01383-z. Online ahead of print. ABSTRACT The retinal pigment epithelium (RPE) is a highly specialized and polarized epithelial cell layer that plays an important role in sustaining the structural and functional integrity of photoreceptors. However, the death of RPE is a common pathological feature in various retinal diseases, […]
Inhibition of DRP1-dependent mitochondrial fission by Mdivi-1 alleviates atherosclerosis through the modulation of M1 polarization
J Transl Med. 2023 Jun 30;21(1):427. doi: 10.1186/s12967-023-04270-9. ABSTRACT BACKGROUND: Inflammation and immune dysfunction with classically activated macrophages(M1) infiltration are important mechanisms in the progression of atherosclerosis (AS). Dynamin-related protein 1 (DRP1)-dependent mitochondrial fission is a novel target for alleviating inflammatory diseases. This study aimed to investigate the effects of DRP1 inhibitor Mdivi-1 on AS. […]
Immunobiology of a rationally-designed AAV2 capsid following intravitreal delivery in mice
Gene Ther. 2023 Jun 29. doi: 10.1038/s41434-023-00409-x. Online ahead of print. ABSTRACT Adeno-associated virus serotype 2 (AAV2) is a viral vector that can be used to deliver therapeutic genes to diseased cells in the retina. One strategy for altering AAV2 vectors involves the mutation of phosphodegron residues, which are thought to be phosphorylated/ubiquitinated in the […]
Progress in the Treatment of High Altitude Cerebral Edema: Targeting REDOX Homeostasis
J Inflamm Res. 2023 Jun 23;16:2645-2660. doi: 10.2147/JIR.S415695. eCollection 2023. ABSTRACT With the increasing of altitude activities from low-altitude people, the study of high altitude cerebral edema (HACE) has been revived. HACE is a severe acute mountain sickness associated with exposure to hypobaric hypoxia at high altitude, often characterized by disturbance of consciousness and ataxia. […]
Non-Pharmaceutical Interventions against COVID-19 Causing a Lower Trend in Age of LHON Onset
Genes (Basel). 2023 Jun 12;14(6):1253. doi: 10.3390/genes14061253. ABSTRACT Leber hereditary optic neuropathy (LHON) is a monogenic but multifactorial disease vulnerable to environmental triggers. Little is known about how LHON onset changed during the COVID-19 pandemic and how non-pharmaceutical interventions (NPHIs) against COVID-19 impact LHON onset. One hundred and forty-seven LHON patients with the m.11778G>A mutation […]
A p-Tyr42 RhoA Inhibitor Promotes the Regeneration of Human Corneal Endothelial Cells by Ameliorating Cellular Senescence
Antioxidants (Basel). 2023 May 30;12(6):1186. doi: 10.3390/antiox12061186. ABSTRACT The development of treatment strategies for human corneal endothelial cells (hCECs) disease is necessary because hCECs do not regenerate in vivo due to the properties that are similar to senescence. This study is performed to investigate the role of a p-Tyr42 RhoA inhibitor (MH4, ELMED Inc., Chuncheon) […]
Role of NADPH Oxidase 4 in Corneal Endothelial Cells Is Mediated by Endoplasmic Reticulum Stress and Autophagy
Antioxidants (Basel). 2023 Jun 7;12(6):1228. doi: 10.3390/antiox12061228. ABSTRACT Human corneal-endothelial cells (hCEnCs) are located on the inner layer of the cornea. Injury to CEnCs leads to permanent corneal edema, requiring corneal transplantation. NADPH oxidase 4 (NOX4) has been reported to be implicated in the pathogenesis of CEnCs diseases. Thus, we investigated the role of NOX4 […]
TRIM25 inhibition attenuates inflammation, senescence, and oxidative stress in microvascular endothelial cells induced by hyperglycemia
Graefes Arch Clin Exp Ophthalmol. 2023 Jun 27. doi: 10.1007/s00417-023-06160-8. Online ahead of print. ABSTRACT PURPOSES: This work aimed to assess the possible role of TRIM25 in regulating hyperglycemia-induced inflammation, senescence, and oxidative stress in retinal microvascular endothelial cells, all of which exert critical roles in the pathological process of diabetic retinopathy. METHODS: The effects […]
Metformin inhibits methylglyoxal-induced retinal pigment epithelial cell death and retinopathy via AMPK-dependent mechanisms: Reversing mitochondrial dysfunction and upregulating glyoxalase 1
Redox Biol. 2023 Jun 15;64:102786. doi: 10.1016/j.redox.2023.102786. Online ahead of print. ABSTRACT Diabetic retinopathy (DR) is a major cause of blindness in adult, and the accumulation of advanced glycation end products (AGEs) is a major pathologic event in DR. Methylglyoxal (MGO), a highly reactive dicarbonyl compound, is a precursor of AGEs. Although the therapeutic potential […]
Three-Dimensional Spheroid Configurations and Cellular Metabolic Properties of Oral Squamous Carcinomas Are Possible Pharmacological and Pathological Indicators
Cancers (Basel). 2023 May 17;15(10):2793. doi: 10.3390/cancers15102793. ABSTRACT The objective of the current study was to elucidate the clinicopathological significance and appearance of in vitro three-dimension (3D) spheroid models of oral malignant tumors that were prepared from four pathologically different squamous cell carcinoma (OSCC; low-grade; SSYP and MO-1000, intermediate-grade; LEM2) and oral adenosquamous carcinoma (OASC; […]