Nystagmus in the B6(CG)Tyr(c-2J)/J Albino Mouse: A Functional and RNA-Seq Analysis
Invest Ophthalmol Vis Sci. 2024 Jan 2;65(1):26. doi: 10.1167/iovs.65.1.26. ABSTRACT PURPOSE: Infantile nystagmus syndrome (INS) is a gaze-holding disorder characterized by conjugate, uncontrolled eye oscillations that can result in significant visual acuity loss. INS is often associated with albinism, but the mechanism is unclear. Albino mice have nystagmus; however, a pigmented mouse with a tyr […]
Distinct Metabolic Profiles of Ocular Hypertensives in Response to Hypoxia
Int J Mol Sci. 2023 Dec 22;25(1):195. doi: 10.3390/ijms25010195. ABSTRACT Glaucoma is a neurodegenerative disease that affects the retinal ganglion cells (RGCs). The main risk factor is elevated intraocular pressure (IOP), but the actual cause of the disease remains unknown. Emerging evidence indicates that metabolic dysfunction plays a central role. The aim of the current […]
Lipid Metabolism Regulators Are the Possible Determinant for Characteristics of Myopic Human Scleral Stroma Fibroblasts (HSSFs)
Int J Mol Sci. 2023 Dec 29;25(1):501. doi: 10.3390/ijms25010501. ABSTRACT The purpose of the current investigation was to elucidate what kinds of responsible mechanisms induce elongation of the sclera in myopic eyes. To do this, two-dimensional (2D) cultures of human scleral stromal fibroblasts (HSSFs) obtained from eyes with two different axial length (AL) groups, <26 […]
The Relationship between Complements and Age-Related Macular Degeneration and Its Pathogenesis
J Ophthalmol. 2024 Jan 2;2024:6416773. doi: 10.1155/2024/6416773. eCollection 2024. ABSTRACT Age-related macular degeneration is a retinal disease that causes permanent loss of central vision in people over the age of 65. Its pathogenesis may be related to mitochondrial dysfunction, inflammation, apoptosis, autophagy, complement, intestinal flora, and lipid disorders. In addition, the patient’s genes, age, gender, […]
Butyrate reduction and HDAC4 increase underlie maternal high fructose-induced metabolic dysfunction in hippocampal astrocytes in female rats
J Nutr Biochem. 2024 Jan 8:109571. doi: 10.1016/j.jnutbio.2024.109571. Online ahead of print. ABSTRACT Maternal nutrient intake influences the health of the offspring via microenvironmental systems in digestion and absorption. Maternal high fructose diet (HFD) impairs hippocampus-dependent memory in adult female rat offspring. However, the underlying mechanisms remain largely unclear. Maternal HFD causes microbiota dysbiosis. In […]
Long-term prognosis of fatty-acid oxidation disorders in adults: Optimism despite the limited effective therapies available
Eur J Neurol. 2024 Feb;31(2):e16138. doi: 10.1111/ene.16138. Epub 2023 Nov 28. ABSTRACT INTRODUCTION: Fatty-acid oxidation disorders (FAODs) are recessive genetic diseases. MATERIALS AND METHODS: We report here clinical and paraclinical data from a retrospective study of 44 adults with muscular FAODs from six French reference centers for neuromuscular or metabolic diseases. RESULTS: The study cohort […]
Trilliumosides K and L, two novel steroidal saponins from rhizomes of Trillium govanianum, as potent anti-cancer agents targeting apoptosis in the A-549 cancer cell line
Front Chem. 2023 Dec 22;11:1306271. doi: 10.3389/fchem.2023.1306271. eCollection 2023. ABSTRACT Two novel steroidal saponins, trilliumosides K (1) and L (2), were isolated from the rhizomes of Trillium govanianum led by bioactivity-guided phytochemical investigation along with seven known compounds: govanoside D (3), protodioscin (4), borassoside E (5), 20-hydroxyecdysone (6), 5,20-hydroxyecdysone (7), govanic acid (8), and diosgenin […]
Subacute-onset cataract in a 29-year-old man with mitochondrial encephalomyopathy: A case report
Clin Case Rep. 2024 Jan 4;12(1):e8417. doi: 10.1002/ccr3.8417. eCollection 2024 Jan. ABSTRACT This case report aims to emphasize that subacute occurrence of nuclear cataract might be one of the underestimated manifestations of mitochondrial encephalomyopathy, thus periodical ophthalmologic examinations are recommended. PMID:38188847 | PMC:PMC10766551 | DOI:10.1002/ccr3.8417
UCP2-SIRT3 Signaling Relieved Hyperglycemia-Induced Oxidative Stress and Senescence in Diabetic Retinopathy
Invest Ophthalmol Vis Sci. 2024 Jan 2;65(1):14. doi: 10.1167/iovs.65.1.14. ABSTRACT PURPOSE: Diabetic retinopathy (DR) is one of the most common reasons for blindness. uncoupling protein 2 (UCP2), an uncoupling protein located in mitochondria, has been reported to be related to metabolic and vascular diseases. This research aimed to illustrate the function and mechanism of UCP2 […]
VDAC1, as a downstream molecule of MLKL, participates in OGD/R-induced necroptosis by inducing mitochondrial damage
Heliyon. 2023 Dec 11;10(1):e23426. doi: 10.1016/j.heliyon.2023.e23426. eCollection 2024 Jan 15. ABSTRACT Ischemia-reperfusion (I/R) injury constitutes a significant risk factor for a range of diseases, including ischemic stroke, myocardial infarction, and trauma. Following the restoration of blood flow post-tissue ischemia, oxidative stress can lead to various forms of cell death, including necrosis, apoptosis, autophagy, and necroptosis. […]