Development of novel cytoprotective small compounds inhibiting mitochondria-dependent cell death
iScience. 2023 Sep 17;26(10):107916. doi: 10.1016/j.isci.2023.107916. eCollection 2023 Oct 20. ABSTRACT We identified cytoprotective small molecules (CSMs) by a cell-based high-throughput screening of Bax inhibitors. Through a medicinal chemistry program, M109S was developed, which is orally bioactive and penetrates the blood-brain/retina barriers. M109S protected retinal cells in ocular disease mouse models. M109S directly interacted with […]
An early glycolysis burst in microglia regulates mitochondrial dysfunction in oligodendrocytes under neuroinflammation
iScience. 2023 Sep 15;26(10):107921. doi: 10.1016/j.isci.2023.107921. eCollection 2023 Oct 20. ABSTRACT Metabolism and energy processes governing oligodendrocyte function during neuroinflammatory disease are of great interest. However, how varied cellular environments affect oligodendrocyte activity during neuroinflammation is unknown. We demonstrate that activated microglial energy metabolism controls oligodendrocyte mitochondrial respiration and activity. Lipopolysaccharide/interferon gamma promote glycolysis and […]
COG1410 regulates microglial states and protects retinal ganglion cells in retinal ischemia-reperfusion injury
Exp Eye Res. 2023 Oct 13:109678. doi: 10.1016/j.exer.2023.109678. Online ahead of print. ABSTRACT Progressive loss of retinal ganglion cells (RGCs) caused by retinal ischemia-reperfusion (IR) injury can lead to irreversible vision impairment, with neuroinflammatory responses playing an important role in this process. COG1410, a mimetic peptide of apolipoprotein E, has demonstrated protective potential in the […]
Unveiling Neuroprotection and Regeneration Mechanisms in Optic Nerve Injury: Insight from Neural Progenitor Cell Therapy with Focus on Vps35 and Syntaxin12
Cells. 2023 Oct 6;12(19):2412. doi: 10.3390/cells12192412. ABSTRACT Axonal degeneration resulting from optic nerve damage can lead to the progressive death of retinal ganglion cells (RGCs), culminating in irreversible vision loss. We contrasted two methods for inducing optic nerve damage: optic nerve compression (ONCo) and optic nerve crush (ONCr). These were assessed for their respective merits […]
Astrocytes of the eye and optic nerve: heterogeneous populations with unique functions mediate axonal resilience and vulnerability to glaucoma
Front Ophthalmol (Lausanne). 2023;3:1217137. doi: 10.3389/fopht.2023.1217137. Epub 2023 Jul 21. ABSTRACT The role of glia, particularly astrocytes, in mediating the central nervous system’s response to injury and neurodegenerative disease is an increasingly well studied topic. These cells perform myriad support functions under physiological conditions but undergo behavioral changes – collectively referred to as ‘reactivity’ – […]
Near-Infrared BODIPY Photosensitizer for Modulating Mitochondrial Fusion Proteins and Inhibiting Choroidal Neovascularization
ACS Appl Mater Interfaces. 2023 Oct 9. doi: 10.1021/acsami.3c11053. Online ahead of print. ABSTRACT Photosensitizers have emerged as cytotoxic reactive oxygen species (ROS) activators in photodynamic therapy (PDT), which induced cell apoptosis. As the major contributors to ROS and oxidative stress, mitochondria play an important role in cell apoptosis. Although there are many reports about […]
cGAS-STING Pathway Activation and Systemic Anti-Tumor Immunity Induction via Photodynamic Nanoparticles with Potent Toxic Platinum DNA Intercalator Against Uveal Melanoma
Adv Sci (Weinh). 2023 Oct 9:e2302895. doi: 10.1002/advs.202302895. Online ahead of print. ABSTRACT The cGAS-STING pathway, as a vital innate immune signaling pathway, has attracted considerable attention in tumor immunotherapy research. However, STING agonists are generally incapable of targeting tumors, thus limiting their clinical applications. Here, a photodynamic polymer (P1) is designed to electrostatically couple […]
Use of 31 P magnetisation transfer magnetic resonance spectroscopy to measure ATP changes after 670 nm transcranial photobiomodulation in older adults
Aging Cell. 2023 Oct 6:e14005. doi: 10.1111/acel.14005. Online ahead of print. ABSTRACT Mitochondrial function declines with age, and many pathological processes in neurodegenerative diseases stem from this dysfunction when mitochondria fail to produce the necessary energy required. Photobiomodulation (PBM), long-wavelength light therapy, has been shown to rescue mitochondrial function in animal models and improve human […]
Early proteomic characteristics and changes in the optic nerve head, optic nerve, and retina in a rat model of ocular hypertension
Mol Cell Proteomics. 2023 Oct 2:100654. doi: 10.1016/j.mcpro.2023.100654. Online ahead of print. ABSTRACT The pathogenesis of glaucoma is still unknown. There are few studies on the dynamic change of tissue-specific and time-specific molecular pathophysiology caused by ocular hypertension (OHT). This study aimed to identify the early proteomic alterations in the retina, optic nerve head (ONH), […]
Repeated Low-Level Red-Light Therapy for Controlling Onset and Progression of Myopia-a Review
Int J Med Sci. 2023 Sep 4;20(10):1363-1376. doi: 10.7150/ijms.85746. eCollection 2023. ABSTRACT Repeated low-level red-light (RLRL), characterized by increased energy supply and cellular metabolism, thus enhancing metabolic repair processes, has gained persistent worldwide attention in recent years as a new novel scientific approach for therapeutic application in myopia. This therapeutic revolution led by RLRL therapy […]