Correction: PSF functions as a repressor of hypoxia-induced angiogenesis by promoting mitochondrial function
Cell Commun Signal. 2023 Jul 24;21(1):183. doi: 10.1186/s12964-023-01237-7. NO ABSTRACT PMID:37488561 | DOI:10.1186/s12964-023-01237-7
Exome sequencing reveals IFT172 variants in patients with non-syndromic cholestatic liver disease
PLoS One. 2023 Jul 20;18(7):e0288907. doi: 10.1371/journal.pone.0288907. eCollection 2023. ABSTRACT BACKGROUND AND AIM: Gene defects contribute to the aetiology of intrahepatic cholestasis. We aimed to explore the outcome of whole-exome sequencing (WES) in a cohort of 51 patients with this diagnosis. PATIENTS AND METHODS: Both paediatric (n = 33) and adult (n = 18) patients […]
Exposure to long wavelength light that improves aged mitochondrial function shifts acute cytokine expression in serum and the retina
PLoS One. 2023 Jul 21;18(7):e0284172. doi: 10.1371/journal.pone.0284172. eCollection 2023. ABSTRACT Aged mitochondrial function can be improved with long wavelength light exposure. This reduces cellular markers of inflammation and can improve system function from fly through to human. We have previously shown that with age there are increases in cytokine expression in mouse serum. Here, we […]
Mitochondrial DNA 13513G>A Mutation Causing Leber Hereditary Optic Neuropathy Associated With Adult-Onset Renal Failure
J Neuroophthalmol. 2023 Jul 21. doi: 10.1097/WNO.0000000000001946. Online ahead of print. ABSTRACT BACKGROUND: Leber hereditary optic neuropathy (LHON) is one of the more common mitochondrial diseases and is rarely associated with mitochondrial renal disease. We report 3 unrelated patients with a background of adult-onset renal failure who presented to us with LHON and were shown […]
Aqueous Fluid Transcriptome Profiling Differentiates Between Non-Neovascular and Neovascular AMD
Invest Ophthalmol Vis Sci. 2023 Jul 3;64(10):26. doi: 10.1167/iovs.64.10.26. ABSTRACT PURPOSE: Early and intermediate non-neovascular AMD (NN-AMD) has the potential to progress to either advanced NN-AMD with geographic atrophy, or to neovascular AMD (N-AMD) with CNV. This exploratory study performed an unbiased analysis of aqueous humor transcriptome in patients with early or intermediate NN-AMD vs. […]
Diurnal proteome profile of the mouse cerebral cortex: Conditional deletion of the Bmal1 circadian clock gene elevates astrocyte protein levels and cell abundance in the neocortex and hippocampus
Glia. 2023 Jul 20. doi: 10.1002/glia.24443. Online ahead of print. ABSTRACT Circadian oscillators, defined by cellular 24 h clock gene rhythms, are found throughout the brain. Cerebral cortex-specific conditional knockout of the clock gene Bmal1 (Bmal1 CKO) leads to depressive-like behavior, but the molecular link from clock gene to altered behavior is unknown. Further, diurnal […]
Congenital cataracts affect the retinal visual cycle and mitochondrial function: A multi-omics study of GJA8 knockout rabbits
J Proteomics. 2023 Jul 17:104972. doi: 10.1016/j.jprot.2023.104972. Online ahead of print. ABSTRACT Congenital cataracts are a threat to visual development in children, and the visual impairment persists after surgical treatment; however, the mechanisms involved remain unclear. Previous clinical studies have identified the effect of congenital cataracts on retinal morphology and function. To further understand the […]
Mitochondrial genome-encoded long noncoding RNA Cytochrome B and mitochondrial dysfunction in diabetic retinopathy
Antioxid Redox Signal. 2023 Jul 18. doi: 10.1089/ars.2023.0303. Online ahead of print. ABSTRACT Aim Mitochondrial dysfunction is closely associated with the development of diabetic complications. In diabetic retinopathy, electron transport chain is compromised and mtDNA is damaged, downregulating transcription of mtDNA-encoded cytochrome B (CYTB) and its antisense long noncoding RNA, LncCytB. Our goal was to […]
Prostanoid FP and EP2 Receptor Agonists Induce Epithelial and Subepithelial Fibrogenetic Changes in Human Conjunctival Fibroblasts in Different Manners
J Ocul Pharmacol Ther. 2023 Jul;39(6):404-414. doi: 10.1089/jop.2023.0011. ABSTRACT Purpose: To examine the effects of prostanoid FP and EP2 receptor agonists, PGF2α and Omidenepag (OMD), respectively, on the transforming growth factor beta (TGF-β2) induced conjunctival fibrogenesis. Methods: Two-dimension (2D) and three-dimension (3D) cultures of these fibroblasts were subjected to following analyses: (1) planar proliferation evaluated […]
An optimized temporally controlled Gal4 system in Drosophila reveals degeneration caused by adult-onset neuronal Vps13D knockdown
Front Neurosci. 2023 Jun 29;17:1204068. doi: 10.3389/fnins.2023.1204068. eCollection 2023. ABSTRACT Mutations in the human gene VPS13D cause the adult-onset neurodegenerative disease ataxia. Our previous work showed that disruptions in the Vps13D gene in Drosophila neurons causes mitochondrial defects. However, developmental lethality caused by Vps13D loss limited our understanding of the long-term physiological effects of Vps13D […]