Insulin-like growth factor binding protein-3 mediates hyperosmolar stress-induced mitophagy through the mechanistic target of rapamycin
J Biol Chem. 2023 Sep 8:105239. doi: 10.1016/j.jbc.2023.105239. Online ahead of print. ABSTRACT Hyperosmolarity of the ocular surface triggers inflammation and pathological damage in dry eye disease (DED). In addition to a reduction in quality of life, DED causes vision loss and when severe, blindness. Mitochondrial dysfunction occurs as a consequence of hyperosmolar stress. We […]
The RLR intrinsic antiviral system is expressed in neural retina and restricts lentiviral transduction of human Mueller cells
Exp Eye Res. 2023 Sep 7:109647. doi: 10.1016/j.exer.2023.109647. Online ahead of print. ABSTRACT The retinoic acid-inducible gene I (RIG)-I-like receptor (RLR) family of RNA sensor proteins plays a key role in the innate immune response to viral nucleic acids, including viral gene delivery vectors, but little is known about the expression of RLR proteins in […]
Probucol attenuates high glucose-induced Müller cell damage through enhancing the Nrf2/p62 signaling pathway
Int Ophthalmol. 2023 Sep 9. doi: 10.1007/s10792-023-02859-z. Online ahead of print. ABSTRACT PURPOSE: This study investigated the protective effect of probucol on Müller cells exposed to high glucose conditions and examined potential mechanisms of action. METHODS: Primary human retinal Müller cells were incubated with high glucose (HG, 35 mM) in the present or absence of […]
Pyrroloquinoline quinone drives ATP synthesis in vitro and in vivo and provides retinal ganglion cell neuroprotection
Acta Neuropathol Commun. 2023 Sep 8;11(1):146. doi: 10.1186/s40478-023-01642-6. ABSTRACT Retinal ganglion cells are highly metabolically active requiring strictly regulated metabolism and functional mitochondria to keep ATP levels in physiological range. Imbalances in metabolism and mitochondrial mechanisms can be sufficient to induce a depletion of ATP, thus altering retinal ganglion cell viability and increasing cell susceptibility […]
Physical Properties and Cellular Metabolic Characteristics of 3D Spheroids Are Possible Definitive Indices for the Biological Nature of Cancer-Associated Fibroblasts
Cells. 2023 Aug 28;12(17):2160. doi: 10.3390/cells12172160. ABSTRACT The current study’s objective was to elucidate some currently unknown biological indicators to evaluate the biological nature of cancer-associated fibroblasts (CAFs). For this purpose, four different CAFs, CAFS1, CAFS2, SCC17F and MO-1000, were established using surgical specimens from oral squamous cell carcinomas (OSCC) with different clinical malignant stages […]
Neuropathy, ataxia, retinitis pigmentosa: a case of a mother and two siblings
Ophthalmic Genet. 2023 Sep 6:1-8. doi: 10.1080/13816810.2023.2253905. Online ahead of print. ABSTRACT AIM: We describe the ophthalmic manifestations of Neuropathy, ataxia, retinitis pigmentosa (NARP) syndrome in three related patients. METHODS: We examined a mother and her two children, who were carriers of the mt 8993T>G mutation. The mother, patient I, is the first known carrier […]
Long-term high-fat diet’s impact on synaptic plasticity in the visual cortex and hippocampus neurons: an experimental study
Zhonghua Yan Ke Za Zhi. 2023 Sep 11;59(9):730-739. doi: 10.3760/cma.j.cn112142-20221213-00633. ABSTRACT Objective: To investigate the effects and mechanisms of long-term high-fat diet on synaptic plasticity in the visual cortex and hippocampus neurons of juvenile mice. Methods: This was an experimental study. Twenty-four 4-week-old male C57BL/6J mice were randomly divided into two groups, using a randomized […]
Myopathy and Ophthalmologic Abnormalities in Association With Multiple Skeletal Muscle Mitochondrial DNA Deletions
J Neuroophthalmol. 2023 Sep 4. doi: 10.1097/WNO.0000000000001984. Online ahead of print. ABSTRACT BACKGROUND: Establishing a molecular diagnosis of mitochondrial diseases due to pathogenic mitochondrial DNA (mtDNA) variants can be difficult because of varying levels of tissue heteroplasmy, and identifying these variants is important for clinical management. Here, we present clinical and molecular findings in 8 […]
Safety of YAG laser vitreolysis for intraocular tissues: analysis of postoperative complications
Int Ophthalmol. 2023 Sep 4. doi: 10.1007/s10792-023-02858-0. Online ahead of print. ABSTRACT PURPOSE: To evaluate the safety of yttrium-aluminum-garnet (YAG) laser vitreolysis for intraocular tissues. METHODS: Thirty-six New Zealand rabbits were divided as follows: Group 1000 (n = 12) treated with YAG laser of 1000 mJ (5 mJ × 200 shots), Group 2000 (n = […]
Supramolecular Senolytics via Intracellular Oligomerization of Peptides in Response to Elevated Reactive Oxygen Species Levels in Aging Cells
J Am Chem Soc. 2023 Sep 4. doi: 10.1021/jacs.3c06898. Online ahead of print. ABSTRACT Senolytics, which eliminate senescent cells from tissues, represent an emerging therapeutic strategy for various age-related diseases. Most senolytics target antiapoptotic proteins, which are overexpressed in senescent cells, limiting specificity and inducing severe side effects. To overcome these limitations, we constructed self-assembling […]