PCSK7, a potential target for the treatment of age-related macular degeneration: inhibition of retinal epithelial cell death
Int J Clin Exp Pathol. 2024 Oct 15;17(10):371-380. doi: 10.62347/LEHU9944. eCollection 2024. ABSTRACT BACKGROUND: Age-related macular degeneration (AMD) is a complex disease with a pathophysiology that remains incompletely understood. PCSK7 is closely related to the normal development of ocular tissues; however, the roles and mechanisms of PCSK7 in AMD have yet to be elucidated. Therefore, […]
Multiwavelength photobiomodulation in atrophic age-related macular degeneration
Eur J Ophthalmol. 2024 Nov 15:11206721241298316. doi: 10.1177/11206721241298316. Online ahead of print. ABSTRACT PURPOSE: To evaluate photobiomodulation (PBM) safety and efficacy in patient with atrophic AMD and to explore tissue effects using Spectrally Resolved Autofluorescence (SrAF) to identify a potential biomarker indicative of mitochondrial activity, the primary PBM target. METHODS: This retrospective, non-comparative case series […]
HO-1-Mediated Ferroptosis Regulates Retinal Neovascularization via the COX2/VEGFA Axis
Free Radic Biol Med. 2024 Nov 12:S0891-5849(24)01051-7. doi: 10.1016/j.freeradbiomed.2024.11.017. Online ahead of print. ABSTRACT Retinal neovascularization (RNV) is a key pathological process in many blinding disorders. This study aims to investigate the potential mechanisms of heme oxygenase-1 (HO-1) on ferroptosis during RNV. Through bioinformatics analysis, differentially expressed ferroptosis-related genes were identified in the oxygen-induced retinopathy […]
Editorial: Mitochondrial dysfunction and genetic variations in neuro-ophthalmology diseases
Front Ophthalmol (Lausanne). 2024 Oct 30;4:1483607. doi: 10.3389/fopht.2024.1483607. eCollection 2024. NO ABSTRACT PMID:39539390 | PMC:PMC11557555 | DOI:10.3389/fopht.2024.1483607
RTA408 alleviates retinal ganglion cells damage in mouse glaucoma by inhibiting excessive autophagy
PLoS One. 2024 Nov 11;19(11):e0313446. doi: 10.1371/journal.pone.0313446. eCollection 2024. ABSTRACT BACKGROUND: Glaucoma, characterized by a high incidence and significant ocular harm, has been elucidated through various mechanisms. Excessive autophagy leading to the loss of retinal ganglion cells (RGCs) is suggested as one potential cause for visual impairment in glaucoma. METHODS: A glaucoma model was established […]
Late-Onset Mitochondrial Neurogastrointestinal Encephalopathy Presenting With Isolated Ophthalmic Findings
J Neuroophthalmol. 2024 Nov 11. doi: 10.1097/WNO.0000000000002287. Online ahead of print. NO ABSTRACT PMID:39527508 | DOI:10.1097/WNO.0000000000002287
Leber Hereditary Optic Neuropathy With Significant Visual Recovery: An MT-ND6 Mutation in a Malay Patient
Cureus. 2024 Oct 10;16(10):e71210. doi: 10.7759/cureus.71210. eCollection 2024 Oct. ABSTRACT Leber hereditary optic neuropathy (LHON) is a rare maternally inherited mitochondrial disorder that predominantly affects young men, leading to optic nerve degeneration and subsequent vision loss. The rarity of LHON and its clinical similarity to optic neuritis complicates diagnosis, necessitating genetic testing to confirm specific […]
Structure-Function Correlation in Cobalt-Induced Brain Toxicity
Cells. 2024 Oct 24;13(21):1765. doi: 10.3390/cells13211765. ABSTRACT Cobalt toxicity is difficult to detect and therefore often underdiagnosed. The aim of this study was to explore the pathophysiology of cobalt-induced oxidative stress in the brain and its impact on structure and function. Thirty-five wild-type C57B16 mice received intraperitoneal cobalt chloride injections: a single high dose with […]
Prominin-1 Knockdown Causes RPE Degeneration in a Mouse Model
Cells. 2024 Oct 24;13(21):1761. doi: 10.3390/cells13211761. ABSTRACT There are currently no effective treatments for retinal pigment epithelial (RPE) cell loss in atrophic AMD (aAMD). However, our research on Prominin-1 (Prom1), a known structural protein in photoreceptors (PRs), has revealed its distinct role in RPE and offers promising insights. While pathogenic Prom1 mutations have been linked […]
Mechanisms Regulating Mitochondrial Transfer in Human Corneal Epithelial Cells
Invest Ophthalmol Vis Sci. 2024 Nov 4;65(13):10. doi: 10.1167/iovs.65.13.10. ABSTRACT PURPOSE: The intraepithelial corneal nerves (ICNs) innervating the cornea are essential to corneal epithelial cell homeostasis. Rho-associated kinase (ROCK) inhibitors (RIs) have been reported to play roles in neuron survival after injury and in mitochondrial transfer between corneal epithelial cells. In this study, the mechanisms […]