Category: Ophthalmology AND mitochondrial

Evolution of therapeutic strategy based on oxidant-antioxidant balance for Fuchs endothelial corneal dystrophy

Ocul Surf. 2024 Aug 5:S1542-0124(24)00083-1. doi: 10.1016/j.jtos.2024.08.003. Online ahead of print. ABSTRACT Fuchs endothelial corneal dystrophy (FECD) stands as the most prevalent primary corneal endothelial dystrophy worldwide, posing a significant risk to corneal homeostasis and clarity. Corneal endothelial cells exhibit susceptibility to oxidative stress, suggesting a nuanced relationship between oxidant-antioxidant imbalance and FECD pathogenesis, irrespective […]

Glutamine is the only amino acid that can adequately support the generation of NADPH in rod photoreceptors

Exp Eye Res. 2024 Aug 5:110018. doi: 10.1016/j.exer.2024.110018. Online ahead of print. ABSTRACT NADPH, the primary source of reducing equivalents in the cytosol, is used in vertebrate rod photoreceptor outer segments to reduce the all-trans retinal released from photoactivated visual pigment to all-trans retinol. Light activation of the visual pigment isomerizes the 11-cis retinal chromophore […]

Integrated Histological and Molecular Analysis of Filarial Species and Associated Wolbachia Endosymbionts in Human Filariasis Cases Presenting Atypically in Thailand

Am J Trop Med Hyg. 2024 Aug 6:tpmd240147. doi: 10.4269/ajtmh.24-0147. Online ahead of print. ABSTRACT Atypical presentations of filariasis have posed diagnostic challenges due to the complexity of identifying the causative species and the difficulties in both diagnosis and treatment. In this study, we present the integrative histological and molecular analysis of seven atypical filariasis […]

Novel Variant of FDXR as a Molecular Etiology of Postlingual Post-Synaptic Auditory Neuropathy Spectrum Disorder via Mitochondrial Dysfunction: Reiteration of the Correlation between Genotype and Cochlear Implantation Outcomes

Clin Exp Otorhinolaryngol. 2024 Aug 6. doi: 10.21053/ceo.2024.00184. Online ahead of print. ABSTRACT OBJECTIVES: FDXR encodes the mitochondrial ferredoxin reductase, which is associated with auditory neuropathy spectrum disorder (ANSD) and optic atrophy. Only two studies have described FDXRrelated hearing loss. The auditory rehabilitation outcomes of this disease entity have not been investigated, and the pathophysiologic […]

Discovery of novel disease-causing mutation in SSBP1 and its correction using adenine base editor to improve mitochondrial function

Mol Ther Nucleic Acids. 2024 Jun 17;35(3):102257. doi: 10.1016/j.omtn.2024.102257. eCollection 2024 Sep 10. ABSTRACT Mutations in nuclear genes regulating mitochondrial DNA (mtDNA) replication are associated with mtDNA depletion syndromes. Using whole-genome sequencing, we identified a heterozygous mutation (c.272G>A:p.Arg91Gln) in single-stranded DNA-binding protein 1 (SSBP1), a crucial protein involved in mtDNA replisome. The proband manifested symptoms […]

A Comprehensive Review of Leber Hereditary Optic Neuropathy and Its Association with Multiple Sclerosis-Like Phenotypes Known as Harding’s Disease

Eye Brain. 2024 Jul 29;16:17-24. doi: 10.2147/EB.S470184. eCollection 2024. ABSTRACT Leber Hereditary Optic Neuropathy (LHON) stands as a distinctive maternally inherited mitochondrial disorder marked by painless, subacute central vision loss, primarily affecting young males. This review covers the possible relationship between LHON and multiple sclerosis (MS), covering genetic mutations, clinical presentations, imaging findings, and treatment […]

Mitochondrial control of hypoxia-induced pathological retinal angiogenesis

Angiogenesis. 2024 Aug 3. doi: 10.1007/s10456-024-09940-w. Online ahead of print. ABSTRACT OBJECTIVE: Pathological retinal neovascularization is vision-threatening. In mouse oxygen-induced retinopathy (OIR) we sought to define mitochondrial respiration changes longitudinally during hyperoxia-induced vessel loss and hypoxia-induced neovascularization, and to test interventions addressing those changes to prevent neovascularization. METHODS: OIR was induced in C57BL/6J mice and […]

G-quadruplex-Based Artificial Transmembrane Channels Induce Cancer Cell Apoptosis by Perturbing Potassium Ion Homeostasis

Adv Healthc Mater. 2024 Aug 2:e2402023. doi: 10.1002/adhm.202402023. Online ahead of print. ABSTRACT Transmembrane ion transport modality has received a widespread attention due to its apoptotic activation toward anticancer cell activities. In this study, G-quadruplex-based potassium-specific transmembrane channels have been developed to facilitate the intracellular K+ efflux, which perturbs the cellular ion homeostasis thereby inducing […]

Corosolic acid attenuates cardiac ischemia/reperfusion injury through the PHB2/PINK1/parkin/mitophagy pathway

iScience. 2024 Jul 8;27(8):110448. doi: 10.1016/j.isci.2024.110448. eCollection 2024 Aug 16. ABSTRACT Despite advances in treatment, myocardial infarction remains the leading cause of heart failure and death worldwide, and the restoration of coronary blood flow can also cause heart damage. In this study, we found that corosolic acid (CA), also known as plant insulin, significantly protects […]