Ptosis in human immunodeficiency virus-infected patients under long-term antiretroviral treatment
Clin Neurol Neurosurg. 2024 Dec 13;249:108690. doi: 10.1016/j.clineuro.2024.108690. Online ahead of print. ABSTRACT OBJECTIVE: To present cases of ptosis in HIV-1 patients on long-term antiretroviral therapy (ART) and review the existing literature. METHODS: Five HIV-1-positive patients with slowly progressive bilateral ptosis underwent a comprehensive diagnostic evaluation, including imaging studies, neurophysiological testing, muscle biopsy, and genetic […]
How crosstalk between mitochondria, lysosomes, and other organelles can prevent or promote dry age-related macular degeneration
Exp Eye Res. 2024 Dec 21:110219. doi: 10.1016/j.exer.2024.110219. Online ahead of print. ABSTRACT Organelles such as mitochondria, lysosomes, peroxisomes, and the endoplasmic reticulum form highly dynamic cellular networks and exchange information through sites of physical contact. While each organelle performs unique functions, this inter-organelle crosstalk helps maintain cell homeostasis. Age-related macular degeneration (AMD) is a […]
Extracellular Mitochondria Exacerbate Retinal Pigment Epithelium Degeneration in Diabetic Retinopathy
Diabetes. 2024 Dec 23:db240040. doi: 10.2337/db24-0040. Online ahead of print. ABSTRACT Advances in fundus imaging are revealing disruptions in the neurovascular unit in diabetic retinopathy (DR). In the era of anti-VEGF treatment, a thorough characterization of neurodegeneration is imperative until DR patients are sufficiently cured. Here we demonstrate that extracellular mitochondria exacerbate retinal pigment epithelium […]
Photobiomodulation Therapy for Non-exudative Age-related Macular Degeneration
Int Ophthalmol Clin. 2025 Jan 1;65(1):47-52. doi: 10.1097/IIO.0000000000000543. Epub 2024 Dec 23. ABSTRACT Age-related macular degeneration (AMD) is a chronic condition that causes gradual central vision loss, most commonly in patients 50 years or older. This disease is commonly classified as either dry (non-exudative) or wet (exudative). Most patients with AMD have the non-exudative form, […]
Reprogramming patient-iPSC specific retinal organoids for deciphering epigenetic modifications of RNA methylation
J Chin Med Assoc. 2024 Dec 23. doi: 10.1097/JCMA.0000000000001198. Online ahead of print. ABSTRACT BACKGROUND: Induced pluripotent stem cell (iPSC) technology has emerged as a powerful tool for disease modeling, providing an innovative platform for investigating disease mechanisms. iPSC-derived organoids, including retinal organoids, offer patient-specific models that closely replicate in vivo cellular environments, making them […]
Taurine mechanism in preventing retinal cell damage from acute ocular hypertension through GTPBP3 regulation
Exp Eye Res. 2024 Dec 20:110222. doi: 10.1016/j.exer.2024.110222. Online ahead of print. ABSTRACT We aimed to explore the protective effects and underlying mechanisms of taurine on retinal cells during acute ocular hypertension (AOH)-induced damage. Retinal morphology, apoptosis, mitochondrial structure, electroretinography, expression of GTP binding protein 3 (GTPBP3), and molecules in the unfolded protein response (UPR) […]
PRDX4 mitigates diabetic retinopathy by inhibiting reactive gliosis, apoptosis, ER stress, oxidative stress, and mitochondrial dysfunction in Muller cells
J Biol Chem. 2024 Dec 18:108111. doi: 10.1016/j.jbc.2024.108111. Online ahead of print. ABSTRACT Diabetic retinopathy (DR) is a neurovascular complication of diabetes. As a crucial player in the retinal physiology, Müller cells are affected in DR, impairments of Müller cell function lead to retinal malfunctions. Therefore, searching for approaches to mitigate diabetes-induced injury in Müller […]
Clinical trials in Leber hereditary optic neuropathy: outcomes and opportunities
Curr Opin Neurol. 2024 Dec 23. doi: 10.1097/WCO.0000000000001343. Online ahead of print. ABSTRACT PURPOSE OF REVIEW: Leber hereditary optic neuropathy (LHON) is a mitochondrial DNA disease characterised by sequential bilateral vision loss due to loss of retinal ganglion cells. The purpose of this review is to provide an update on the results of recent clinical […]
Proteomic Alterations in Retinal Müller Glial Cells Lacking Interleukin-6 Receptor: A Comprehensive Analysis
Invest Ophthalmol Vis Sci. 2024 Dec 2;65(14):33. doi: 10.1167/iovs.65.14.33. ABSTRACT PURPOSE: Interleukin-6 (IL-6) is an inflammatory cytokine implicated in various retinal pathologies and functions primarily through two signaling pathways: cis-signaling via IL-6 binding to its membrane-bound receptor (IL-6Rα), and trans-signaling via IL-6 binding to soluble IL-6 receptor (sIL-6R). Because the differential effects of IL-6 signaling […]
Five-Year Outcomes of Lenadogene Nolparvovec Gene Therapy in Leber Hereditary Optic Neuropathy
JAMA Ophthalmol. 2024 Dec 19. doi: 10.1001/jamaophthalmol.2024.5375. Online ahead of print. ABSTRACT IMPORTANCE: Limited studies have assessed the long-term benefit/risk of gene therapy for Leber hereditary optic neuropathy (LHON). OBJECTIVE: To determine the safety and efficacy of lenadogene nolparvovec in patients with LHON due to the MT-ND4 gene variant for up to 5 years after […]