Ellipsoid Zone Reflectivity: Exploring its Potential as a Novel Non-Invasive Biomarker for Assessing Mitochondrial Function
Neuroophthalmology. 2024 Jun 5;48(6):417-428. doi: 10.1080/01658107.2024.2341769. eCollection 2024. ABSTRACT The ellipsoid zone (EZ) on macular optical coherence tomography (OCT) scans exhibits high intensity due to a high density of light-scattering mitochondria, making its reflectivity a potential marker for mitochondrial function. Here, we developed a reliable analysis tool for extracting relative EZ reflectivity and explore its […]
Defective Neurogenesis in Lowe Syndrome is Caused by Mitochondria Loss and Cilia-related Sonic Hedgehog Defects
bioRxiv [Preprint]. 2024 Nov 1:2024.11.01.621496. doi: 10.1101/2024.11.01.621496. ABSTRACT Human brain development is a complex process that requires intricate coordination of multiple cellular and developmental events. Dysfunction of lipid metabolism can lead to neurodevelopmental disorders. Lowe syndrome (LS) is a recessive X-linked disorder associated with proximal tubular renal disease, congenital cataracts and glaucoma, and central nervous […]
Respiratory Chain Complex I Deficiency in Leber Hereditary Optic Neuropathy: Insights from Ophthalmologic and Molecular Investigations in Tunisia
BMC Genomics. 2024 Nov 22;25(1):1133. doi: 10.1186/s12864-024-11060-0. ABSTRACT BACKGROUND: Leber hereditary optic neuropathy (LHON) is a mitochondrial DNA (mtDNA) rare disease due to the pathogenic variant of the NADH dehydrogenase enzyme. LHON is characterized by a sudden central vision loss due to focal degeneration of the retinal ganglion cell layer and optic nerve. Symptoms usually […]
LINC02154 promotes cell cycle and mitochondrial function in oral squamous cell carcinoma
Cancer Sci. 2024 Nov 22. doi: 10.1111/cas.16379. Online ahead of print. ABSTRACT Long noncoding RNAs (lncRNAs) play pivotal roles in the development of human malignancies, though their involvement in oral squamous cell carcinoma (OSCC) remains incompletely understood. Using The Cancer Genome Atlas (TCGA) dataset, we analyzed expression of 7840 lncRNAs in primary head and neck […]
Honokiol protects against diabetic retinal microvascular injury via sirtuin 3-mediated mitochondrial fusion
Front Pharmacol. 2024 Oct 22;15:1485831. doi: 10.3389/fphar.2024.1485831. eCollection 2024. ABSTRACT INTRODUCTION: Mitochondrial dysfunction and oxidative stress play important roles in diabetic retinal vascular injuries. Honokiol (HKL) is a small-molecule polyphenol that exhibits antioxidant effects and has a beneficial effect in diabetes. This study aimed to explore the potential ability of HKL to ameliorate vascular injury […]
Mutation of CRYAB encoding a conserved mitochondrial chaperone and anti-apoptotic protein causes hereditary optic atrophy
JCI Insight. 2024 Nov 19:e182209. doi: 10.1172/jci.insight.182209. Online ahead of print. ABSTRACT The degeneration of retinal ganglion cells (RGC) due to mitochondrial dysfunctions manifests optic neuropathy. However, the molecular components of RGC linked to optic neuropathy manifestations remain largely unknown. Here, we identified a novel optic atrophy-causative CRYAB gene encoding a highly conserved major lens […]
Long noncoding RNAs and metabolic memory associated with continued progression of diabetic retinopathy
J Diabetes. 2024 Nov;16(11):e70009. doi: 10.1111/1753-0407.70009. ABSTRACT Progression of diabetic retinopathy resists arrest even after institution of intensive glycemic control, suggesting a “metabolic memory” phenomenon, but the mechanism responsible for this phenomenon is still elusive. Gene expression and biological processes can also be regulated by long noncoding RNAs (LncRNAs), the RNAs with >200 nucleotides and […]
Recent advances associated with cardiometabolic remodeling in diabetes-induced heart failure
Am J Physiol Heart Circ Physiol. 2024 Dec 1;327(6):H1327-H1342. doi: 10.1152/ajpheart.00539.2024. Epub 2024 Oct 25. ABSTRACT Diabetes mellitus (DM) is characterized by chronic hyperglycemia, and despite intensive glycemic control, the risk of heart failure in patients with diabetes remains high. Diabetes-induced heart failure (DHF) presents a unique metabolic challenge, driven by significant alterations in cardiac […]
Novel Emerging Mechanisms in Acetaminophen (APAP) Hepatotoxicity
Liver Int. 2024 Nov 15. doi: 10.1111/liv.16167. Online ahead of print. ABSTRACT BACKGROUND: Drug-induced liver injury represents a critical public health issue, marked by unpredictable and potentially severe adverse reactions to medications, herbal products or dietary supplements. AIMS: Acetaminophen is notably a leading cause of hepatotoxicity, impacting over one million individuals worldwide. MATERIALS & METHODS: […]
Oxidative Stress and Inflammation-Related mRNAs Are Elevated in Serum of a Finnish Wet AMD Cohort
Invest Ophthalmol Vis Sci. 2024 Nov 4;65(13):30. doi: 10.1167/iovs.65.13.30. ABSTRACT PURPOSE: Localized diseases can be affected by and affect the systemic environment via blood circulation. In this study, we explored the differences in circulating serum mRNAs between patients with wet AMD (wAMD) and controls. METHODS: Blood samples were obtained from 60 Finnish patients with wAMD […]