Intraocular fatty acids induce reinforcement of barrier functions on the outer blood-retinal barrier
Prostaglandins Leukot Essent Fatty Acids. 2024 Aug 8;202:102637. doi: 10.1016/j.plefa.2024.102637. Online ahead of print. ABSTRACT The aim of the present study was to elucidate unknown effects of intraocular fatty acids (ioFAs) including palmitic acid (C16:0), stearic acid (C18:0), oleic acid (C18:1), linoleic acid (C18:2), arachidonic acid (C20:4), eicosapentaenoic acid (EPA, C20:5) and docosahexaenoic acid (DHA, […]
Inducible RPE-specific GPX4 knockout causes oxidative stress and retinal degeneration with features of age-related macular degeneration
Exp Eye Res. 2024 Aug 9:110028. doi: 10.1016/j.exer.2024.110028. Online ahead of print. ABSTRACT Age-related macular degeneration (AMD) is one of the leading causes of vision loss in the elderly. This disease involves oxidative stress burden in the retina leading to death of retinal pigment epithelial (RPE) cells and photoreceptors. The retina is susceptible to oxidative […]
Dynasore Modulates Store-Operated Calcium Entry and Mitochondrial Calcium Release in Corneal Epithelial Cells
Exp Eye Res. 2024 Aug 8:110029. doi: 10.1016/j.exer.2024.110029. Online ahead of print. ABSTRACT Dysregulation of calcium homeostasis can precipitate a cascade of pathological events that lead to tissue damage and cell death. Dynasore is a small molecule that inhibits endocytosis by targeting classic dynamins. In a previous study, we showed that dynasore can protect human […]
Inhibition of angiogenesis by the secretome from iPSC-derived retinal ganglion cells with Leber’s hereditary optic neuropathy-like phenotypes
Biomed Pharmacother. 2024 Aug 9;178:117270. doi: 10.1016/j.biopha.2024.117270. Online ahead of print. ABSTRACT The blood supply in the retina ensures photoreceptor function and maintains regular vision. Leber’s hereditary optic neuropathy (LHON), caused by the mitochondrial DNA mutations that deteriorate complex I activity, is characterized by progressive vision loss. Although some reports indicated retinal vasculature abnormalities as […]
The Scavenging Activity of Coenzyme Q10 Plus a Nutritional Complex on Human Retinal Pigment Epithelial Cells
Int J Mol Sci. 2024 Jul 24;25(15):8070. doi: 10.3390/ijms25158070. ABSTRACT Age-related macular degeneration (AMD) and diabetic retinopathy (DR) are common retinal diseases responsible for most blindness in working-age and elderly populations. Oxidative stress and mitochondrial dysfunction play roles in these pathogenesis, and new therapies counteracting these contributors could be of great interest. Some molecules, like […]
PDK4-mediated metabolic reprogramming is a potential therapeutic target for neovascular age-related macular degeneration
Cell Death Dis. 2024 Aug 9;15(8):582. doi: 10.1038/s41419-024-06968-0. ABSTRACT Age-related macular degeneration (AMD) causes severe blindness in the elderly due to choroidal neovascularization (CNV), which results from the dysfunction of the retinal pigment epithelium (RPE). While normal RPE depends exclusively on mitochondrial oxidative phosphorylation for energy production, the inflammatory conditions associated with metabolic reprogramming of […]
Pericyte loss via glutaredoxin2 downregulation aggravates diabetes-induced microvascular dysfunction
Exp Eye Res. 2024 Aug 6:110025. doi: 10.1016/j.exer.2024.110025. Online ahead of print. ABSTRACT Diabetic retinopathy (DR) is the leading cause of vision loss and blindness among working-age adults. Pericyte loss is an early pathological feature of DR. Under hyperglycemic conditions, reactive oxygen species (ROS) production increases, leading to oxidative stress and subsequent mitochondrial dysfunction and […]
TRB3 Promotes Cataract Progression through Endoplasmic Reticulum Stress-mediated Mitochondrial Dysfunction and Cell Apoptosis
Cell Biochem Biophys. 2024 Aug 8. doi: 10.1007/s12013-024-01470-y. Online ahead of print. ABSTRACT Cataracts are characterized as a disease affecting lens opacity. Endoplasmic reticulum (ER) stress can cause lens epithelial cell (LEC) dysfunction, affecting normal lens transparency and function, but the role of Tribbles 3 (TRB3), an inducible gene of ER stress, in cataracts is […]
Cytosolic protein translation regulates cell asymmetry and function in early TCR activation of human CD8+ T lymphocytes
Front Immunol. 2024 Jul 24;15:1411957. doi: 10.3389/fimmu.2024.1411957. eCollection 2024. ABSTRACT INTRODUCTION: CD8+ cytotoxic T lymphocytes (CTLs) are highly effective in defending against viral infections and tumours. They are activated through the recognition of peptide-MHC-I complex by the T-cell receptor (TCR) and co-stimulation. This cognate interaction promotes the organisation of intimate cell-cell connections that involve cytoskeleton […]
Minocycline alleviates microglia ferroptosis by inhibiting HO-1 during cerebral ischemia-reperfusion injury
Inflamm Res. 2024 Aug 7. doi: 10.1007/s00011-024-01927-z. Online ahead of print. ABSTRACT OBJECTIVE: Ischemic stroke is a leading cause of death and disability in individuals worldwide. Cerebral ischemia-reperfusion injury (CIRI) typically results in severe secondary injury and complications following reperfusion therapy. Microglia play critical roles in the inflammatory reaction of CIRI. However, less attention has […]