Eye on the horizon: The metabolic landscape of the RPE in aging and disease
Prog Retin Eye Res. 2024 Oct 19:101306. doi: 10.1016/j.preteyeres.2024.101306. Online ahead of print. ABSTRACT To meet the prodigious bioenergetic demands of the photoreceptors, glucose and other nutrients must traverse the retinal pigment epithelium (RPE), a polarised monolayer of cells that lie at the interface between the outer retina and the choroid, the principal vascular layer […]
Mitochondrial Transfer Via Tunneling Nanotubes Between Mesenchymal Stem Cells and Retinal Pigment Epithelium In Vitro
J Vis Exp. 2024 Oct 4;(212). doi: 10.3791/66917. ABSTRACT Mitochondrial transfer is a normal physiological phenomenon that occurs widely among various types of cells. In the study to date, the most important pathway for mitochondrial transport is through tunneling nanotubes (TNTs). There have been many studies reporting that mesenchymal stem cells (MSCs) can transfer mitochondria […]
A novel ferroptosis inhibitor, Thonningianin A, improves Alzheimer’s disease by activating GPX4
Theranostics. 2024 Sep 23;14(16):6161-6184. doi: 10.7150/thno.98172. eCollection 2024. ABSTRACT Background: Ferroptosis, a recently unveiled iron-dependent form of cellular demise, has emerged as a pivotal process contributing to the pathology of Alzheimer’s Disease (AD). Glutathione Peroxidase 4 (GPX4), a vital defense mechanism countering ferroptosis by nullifying lipid peroxides and maintaining cellular redox equilibrium, has garnered significant […]
Photobiomodulation in Ophthalmology: A Comprehensive Review of Bench-to-Bedside Research and Clinical Integration
Cureus. 2024 Sep 18;16(9):e69651. doi: 10.7759/cureus.69651. eCollection 2024 Sep. ABSTRACT Photobiomodulation (PBM), also known as low-level laser therapy, is an emerging therapeutic modality in ophthalmology, attracting increasing interest for its potential to manage a variety of ocular conditions. PBM employs low-energy light within the red and near-infrared spectrum to penetrate biological tissues, where it interacts […]
Retinal pigment epithelium-specific ablation of GPx4 in adult mice recapitulates key features of geographic atrophy in age-related macular degeneration
Cell Death Dis. 2024 Oct 19;15(10):763. doi: 10.1038/s41419-024-07150-2. ABSTRACT Age-related macular degeneration (AMD) is a leading cause of irreversible vision loss in the elderly population, particularly the late-stage of dry AMD known as geographic atrophy (GA), lacks effective treatment options. Genetic mouse models of AMD have revealed the significance of impaired lipid metabolism and anti-oxidative […]
Correction: Mitochondrial control of hypoxia-induced pathological retinal angiogenesis
Angiogenesis. 2024 Oct 19. doi: 10.1007/s10456-024-09952-6. Online ahead of print. NO ABSTRACT PMID:39425886 | DOI:10.1007/s10456-024-09952-6
Clinical and genetic landscape of optic atrophy in 826 families: insights from 50 nuclear genes
Brain. 2024 Oct 18:awae324. doi: 10.1093/brain/awae324. Online ahead of print. ABSTRACT Hereditary optic neuropathies (HON) are a group of diseases due to genetic defects either in mitochondria or in nuclear genomes. The increasing availability of genetic testing has expanded a broader genetic and phenotypic spectrum of HON than previously recognized. To provide systematic insight into […]
Meta-analysis of treatment outcomes for patients with m.11778G>A MT-ND4 Leber Hereditary Optic Neuropathy
Surv Ophthalmol. 2024 Oct 15:S0039-6257(24)00130-9. doi: 10.1016/j.survophthal.2024.10.002. Online ahead of print. ABSTRACT Our aim was to assess the visual outcomes of patients with Leber hereditary optic neuropathy (LHON) harboring the m.11778G>A MT-ND4 mutation who had no treatment (natural history) or received idebenone or lenadogene nolparvovec. Efficacy outcomes included clinically relevant recovery (CRR) from nadir and […]
TiO2-Nanoparticle-Enhanced Sonodynamic Therapy for Prevention of Posterior Capsular Opacification and Ferroptosis Exploration of Its Mechanism
Invest Ophthalmol Vis Sci. 2024 Oct 1;65(12):24. doi: 10.1167/iovs.65.12.24. ABSTRACT PURPOSE: To explore the application and potential ferroptosis mechanisms of sonodynamic therapy (SDT) using titanium dioxide nanoparticles (TiO2-NPs) as sonosensitizers for the prevention of posterior capsule opacification (PCO). METHODS: We fabricated TiO2-NP-coated intraocular lenses (TiO2-IOLs) using the spin-coating method, followed by ultrasound activation of the […]
The Role of Nicotinamide Riboside in the Preservation of Retinal Ganglion Cells Using An In Vitro Glutamate-Induced Excitotoxicity Model
Exp Eye Res. 2024 Oct 14:110126. doi: 10.1016/j.exer.2024.110126. Online ahead of print. ABSTRACT Delaying or preventing the loss of retinal ganglion cells (RGCs) in glaucoma is needed for vision preservation. Glutamate-mediated neurotoxicity arises from the excessive stimulation of N-methyl-D-aspartate membrane receptors by glutamate. This overstimulation, occurring specifically in RGCs, triggers a progressive deterioration of the […]