TiO2-Nanoparticle-Enhanced Sonodynamic Therapy for Prevention of Posterior Capsular Opacification and Ferroptosis Exploration of Its Mechanism
Invest Ophthalmol Vis Sci. 2024 Oct 1;65(12):24. doi: 10.1167/iovs.65.12.24. ABSTRACT PURPOSE: To explore the application and potential ferroptosis mechanisms of sonodynamic therapy (SDT) using titanium dioxide nanoparticles (TiO2-NPs) as sonosensitizers for the prevention of posterior capsule opacification (PCO). METHODS: We fabricated TiO2-NP-coated intraocular lenses (TiO2-IOLs) using the spin-coating method, followed by ultrasound activation of the […]
The Role of Nicotinamide Riboside in the Preservation of Retinal Ganglion Cells Using An In Vitro Glutamate-Induced Excitotoxicity Model
Exp Eye Res. 2024 Oct 14:110126. doi: 10.1016/j.exer.2024.110126. Online ahead of print. ABSTRACT Delaying or preventing the loss of retinal ganglion cells (RGCs) in glaucoma is needed for vision preservation. Glutamate-mediated neurotoxicity arises from the excessive stimulation of N-methyl-D-aspartate membrane receptors by glutamate. This overstimulation, occurring specifically in RGCs, triggers a progressive deterioration of the […]
Copper aggravated synaptic damage after traumatic brain injury by downregulating BNIP3-mediated mitophagy
Autophagy. 2024 Oct 16:1-17. doi: 10.1080/15548627.2024.2409613. Online ahead of print. ABSTRACT Synaptic damage is a crucial pathological process in traumatic brain injury. However, the mechanisms driving this process remain poorly understood. In this report, we demonstrate that the accumulation of damaged mitochondria, resulting from impaired mitphagy, plays a significant role in causing synaptic damage. Moreover, […]
Multifocal vitelliform lesions associated with mitochondrial retinopathy
Am J Ophthalmol Case Rep. 2024 Oct 2;36:102181. doi: 10.1016/j.ajoc.2024.102181. eCollection 2024 Dec. ABSTRACT PURPOSE: To report a case of multifocal vitelliform lesions in a patient affected by metabolic encephalomyopathy, lactic acidosis and stroke-like episodes (MELAS) with the m.3243A>G variant. OBSERVATIONS: A 37-year-old woman affected by MELAS was referred to our center for progressive vision […]
Hypoxia-mediated rescue of retinal ganglion cells deficient in mitochondrial complex I is independent of the hypoxia-inducible factor pathway
Sci Rep. 2024 Oct 15;14(1):24114. doi: 10.1038/s41598-024-75916-x. ABSTRACT Continuous exposure to environmental hypoxia (11% O2) has been shown to markedly slow the progressive degeneration of retinal ganglion cells (RGCs) in a mouse model of mitochondrial optic neuropathy with RGC-specific deletion of the key mitochondrial complex I accessory subunit ndufs4. As a first step toward identifying […]
Exploring the Potential of Synthetic Cannabinoids: Modulation of Biological Activity of Normal and Cancerous Human Colon Epithelial Cells
Cells. 2024 Sep 26;13(19):1616. doi: 10.3390/cells13191616. ABSTRACT Colorectal cancer (CRC) is a global problem. Oncology currently practices conventional methods of treating this carcinoma, including surgery, chemotherapy, and radiotherapy. Unfortunately, their efficacy is low; hence, the exploration of new therapies is critical. Recently, many efforts have focused on developing safe and effective anticancer compounds. Some of […]
Electroacupuncture Slows Experimental Myopia Progression by Improving Retinal Mitochondrial Function: A Study Based on Single-Cell RNA Sequencing
Adv Biol (Weinh). 2024 Oct 15:e2400269. doi: 10.1002/adbi.202400269. Online ahead of print. ABSTRACT This study aimed to establish a complete atlas of retinal cells in lens-induced myopia (LIM) and electroacupuncture (EA) intervention by single-cell RNA sequencing (scRNA-seq) and to explore the potential mechanism of EA in improving experimental myopia progression in guinea pigs. scRNA-seq is […]
Hyperglycemia-depleted glutamine contributes to the pathogenesis of diabetic corneal endothelial dysfunction
Exp Eye Res. 2024 Oct 11:110124. doi: 10.1016/j.exer.2024.110124. Online ahead of print. ABSTRACT Diabetic mellitus causes various complications, including the corneal endothelial dysfunction (CED) that leads to corneal edema and vision loss, especially in the DM patients with intraocular surgeries. However, the pathogenic mechanism of hyperglycemia-caused CED remains incomplete understood. Here we firstly screened and […]
Nrf2 mitigates sepsis-associated encephalopathy-induced hippocampus ferroptosis via modulating mitochondrial dynamic homeostasis
Int Immunopharmacol. 2024 Oct 12;143(Pt 1):113331. doi: 10.1016/j.intimp.2024.113331. Online ahead of print. ABSTRACT Sepsis-associated encephalopathy (SAE) is a serious neurological complication accompanied with acute and long-term cognitive dysfunction. Ferroptosis is a newly discovered type of cell death that is produced by iron-dependent lipid peroxidation. Emerging evidence suggests that ferroptosis is involved in SAE. The nuclear […]
COL8A2 Activation Enhances Function of Corneal Endothelial Cells through HIPPO Signaling/Mitochondria Pathway
Matrix Biol. 2024 Oct 10:S0945-053X(24)00122-7. doi: 10.1016/j.matbio.2024.10.001. Online ahead of print. ABSTRACT Corneal endothelial cells (CECs) are essential for maintaining corneal transparency and hydration through their barrier and pump functions. The COL8A2 gene encodes a component of the extracellular matrix of the cornea, which is crucial for the normal functioning of these cells. Mutations in […]