Vitreal Concentrations of Vascular Endothelial Growth Factor in Patients with Rhegmatogenous Retinal Detachment
J Clin Med. 2023 Feb 5;12(4):1259. doi: 10.3390/jcm12041259. ABSTRACT The purpose of this study is to evaluate the concentration of vascular endothelial growth factor (VEGF) in the vitreous humor of patients with primary rhegmatogenous retinal detachment (RRD). This is a prospective case control study. Eighteen patients with primary RRD without proliferative vitreoretinopathy C (PVR C) […]
Insight into the mechanisms of coronaviruses evading host innate immunity
Biochim Biophys Acta Mol Basis Dis. 2023 Feb 27:166671. doi: 10.1016/j.bbadis.2023.166671. Online ahead of print. ABSTRACT The SARS-CoV-2 induced coronavirus disease (COVID-19) has recently caused a pandemic. Patients with COVID-19 presented with a wide spectrum of symptoms for the disease, from entirely asymptomatic to full-blown pneumonia and multiorgan failures. More evidence emerged, showing the production […]
Harel Yoon syndrome: a novel mutation in ATAD3A gene and expansion of the clinical spectrum
Ophthalmic Genet. 2023 Mar 1:1-8. doi: 10.1080/13816810.2023.2183223. Online ahead of print. ABSTRACT BACKGROUND: Harel-Yoon syndrome (HAYOS) is a recently described neurodevelopmental disorder characterized by psychomotor delay, truncal hypotonia, appendicular spasticity, and peripheral neuropathy. It is caused by mutations in ATAD3A gene located on chromosome 1p.36.33 whose functions include mitochondrial DNA stabilization, the regulation of mitochondrial […]
Rescuing cellular function in Fuchs endothelial corneal dystrophy by healthy exogenous mitochondrial internalization
Sci Rep. 2023 Feb 28;13(1):3380. doi: 10.1038/s41598-023-30383-8. ABSTRACT Fuchs endothelial corneal dystrophy (FECD) is characterized by an accelerated loss of corneal endothelial cells. Since the function of these cells is to maintain the cornea in a state of deturgescence necessary for its transparency, the depletion of corneal endothelial cells ultimately causes corneal edema and irreversible […]
Molybdenum Cofactor Deficiency
2021 Dec 2 [updated 2023 Feb 2]. In: Adam MP, Everman DB, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2023. ABSTRACT CLINICAL CHARACTERISTICS: Molybdenum cofactor deficiency (MoCD) represents a spectrum, with some individuals experiencing significant signs and symptoms in the neonatal […]
PK2/PKRs pathway is involved in the protective effect of artemisinin against trimethyltin chloride-induced hippocampal injury
Toxicology. 2023 Mar 1;486:153432. doi: 10.1016/j.tox.2023.153432. Epub 2023 Jan 22. ABSTRACT Neuroinflammation is one of the important mechanisms of trimethyltin chloride (TMT) central neurotoxicity. Artemisinin (ARS) is a well-known antimalarial drug that also has significant anti-inflammatory effects. Prokineticin 2 (PK2) is a small molecule secreted protein that is widely expressed in the nervous system and […]
Inhibition of mitochondrial VDAC1 oligomerization alleviates apoptosis and necroptosis of retinal neurons following OGD/R injury
Ann Anat. 2023 Jan 20;247:152049. doi: 10.1016/j.aanat.2023.152049. Online ahead of print. ABSTRACT Ischemia-reperfusion (I/R) injury is a common pathological mechanism in many retinal diseases, which can lead to cell death via mitochondrial dysfunction. Voltage-dependent anion channel 1 (VDAC1), which is mainly located in the outer mitochondrial membrane, is the gatekeeper of mitochondria. The permeability of […]
Case Report: Abnormalities of sperm motility and morphology in a patient with Leber hereditary optic neuropathy: Improvement after idebenone therapy
Front Neurol. 2023 Jan 4;13:946559. doi: 10.3389/fneur.2022.946559. eCollection 2022. ABSTRACT CASE: We report the sperm characteristics of a male patient who developed, when he was 18 years old, a Leber hereditary optic neuropathy, a hereditary optic neuropathy due to mtDNA mutation as well as variants in the nuclear DNA. At the age of 30 years-old, […]
The amoebicidal effect of Torreya nucifera extract on Acanthamoeba lugdunensis
PLoS One. 2023 Feb 6;18(2):e0281141. doi: 10.1371/journal.pone.0281141. eCollection 2023. ABSTRACT As the number of contact lens users increases, contact lens induced corneal infection is becoming more common. Acanthamoeba keratitis (AK) is a type of those which is caused by Acanthamoeba species, and may cause severe ocular inflammation and visual loss. We evaluated whether Torreya nucifera […]
Leber’s Hereditary Optic Neuropathy with Mitochondrial DNA Mutation G11778A: A Systematic Literature Review and Meta-Analysis
Biomed Res Int. 2023 Jan 24;2023:1107866. doi: 10.1155/2023/1107866. eCollection 2023. ABSTRACT BACKGROUND: LHON is a progressive disease with early disease onset and male predominance, usually causing devastating visual loss to patients. These systematic review and meta-analysis are aimed at summarizing epidemiology, disease onset and progression, visual recovery, risk factors, and treatment options of Leber’s hereditary […]