Empagliflozin targets Mfn1 and Opa1 to attenuate microglia-mediated neuroinflammation in retinal ischemia and reperfusion injury
J Neuroinflammation. 2023 Dec 12;20(1):296. doi: 10.1186/s12974-023-02982-9. ABSTRACT BACKGROUND: Neuroinflammation and mitochondrial dysfunction play crucial roles in retinal ischemia and reperfusion (IR) injury. Recent studies have identified mitochondrial function as a promising target for immunomodulation. Empagliflozin (EMPA), an anti-diabetic drug, has exhibited great potential as both an anti-inflammatory agent and a protector of mitochondrial health. […]
Hypertrophic cardiomyopathy is characterized by alterations of the mitochondrial calcium uniporter complex proteins: insights from patients with aortic valve stenosis versus hypertrophic obstructive cardiomyopathy
Front Pharmacol. 2023 Nov 22;14:1264216. doi: 10.3389/fphar.2023.1264216. eCollection 2023. ABSTRACT Introduction: Hypertrophies of the cardiac septum are caused either by aortic valve stenosis (AVS) or by congenital hypertrophic obstructive cardiomyopathy (HOCM). As they induce cardiac remodeling, these cardiac pathologies may promote an arrhythmogenic substrate with associated malignant ventricular arrhythmias and may lead to heart failure. […]
PEDF Prevents Mitochondrial Function Decay and ER Stress Induced by Rotenone in Aging RPE Cells
Front Biosci (Landmark Ed). 2023 Nov 29;28(11):319. doi: 10.31083/j.fbl2811319. ABSTRACT BACKGROUND: Neurodegenerative diseases, including age-related macular degeneration (AMD), may be linked to mitochondrial dysfunction and endoplasmic reticulum (ER) stress. We examined whether Pigment epithelium-derived factor (PEDF) could prevent changes in the structure and function of these organelles by accelerating by rotenone (ROT), a mitochondrial inhibitor, […]
Exploring mito-nuclear genetic factors in Leber’s hereditary optic neuropathy: insights from comprehensive profiling of unique cases
EXCLI J. 2023 Oct 9;22:1077-1091. doi: 10.17179/excli2023-6297. eCollection 2023. ABSTRACT Leber’s hereditary optic neuropathy (LHON) is a mitochondrial complex I disorder and causes inexorable painless vision loss. Recent studies from India reported that a significant proportion of LHON patients lack primary mitochondrial DNA mutations, suggesting that alternative genetic factors contribute to disease development. Therefore, this […]
Anti-Nasopharyngeal carcinoma mechanism of sanguinarine based on network pharmacology and molecular docking
Medicine (Baltimore). 2023 Dec 1;102(48):e36477. doi: 10.1097/MD.0000000000036477. ABSTRACT BACKGROUND: The purpose of this study was to investigate the mechanism of sanguinarine (SAN) against nasopharyngeal carcinoma (NPC) by means of network pharmacology, molecular docking technique, and experimental verification. METHODS: The SAN action targets were predicted using the Swiss Target Prediction database, the related NPC targets were […]
In vivo measurement of mitochondrial ROS production in mouse models of photoreceptor degeneration
Redox Biochem Chem. 2023 Dec;5-6:None. doi: 10.1016/j.rbc.2023.100007. ABSTRACT Retinitis pigmentosa (RP) is a disease characterised by photoreceptor cell death. It can be initiated by mutations in a number of different genes, primarily affecting rods, which will die first, resulting in loss of night vision. The secondary death of cones then leads to loss of visual […]
Do multiple physiological OCT biomarkers indicate age-related decline in rod mitochondrial function in C57BL/6J mice?
Front Neurosci. 2023 Nov 17;17:1280453. doi: 10.3389/fnins.2023.1280453. eCollection 2023. ABSTRACT PURPOSE: To test the hypothesis that rod photoreceptor mitochondria function in vivo progressively declines over time. METHODS: 2, 12, and 24 month-old dark- and light-adapted C57BL/6J (B6J) mice were examined by OCT. We measured (i) an index of mitochondrial configuration within photoreceptors measured from the […]
Carnitine palmitoyl-transferase 1A is potentially involved in bovine herpesvirus 1 productive infection
Vet Microbiol. 2023 Nov 30;288:109932. doi: 10.1016/j.vetmic.2023.109932. Online ahead of print. ABSTRACT Bovine herpesvirus 1(BoHV-1) is an important bovine pathogen that causes great economic loss to cattle farms worldwide. The virus-productive infection in bovine kidney (MDBK) cells results in ATP depletion. The mechanisms are not well understood. Mitochondrial fatty acid β-oxidation (FAO) is an important […]
Optic Disc and Retinal Architecture Changes in Patients with Spinocerebellar Ataxia Type 2
Mov Disord. 2023 Nov 30. doi: 10.1002/mds.29675. Online ahead of print. ABSTRACT BACKGROUND: ATXN2 is the causative gene of spinocerebellar ataxia type 2 (SCA2) and has been implicated in glaucoma pathogenesis. Therefore, studying ocular changes in SCA2 could uncover clinically relevant changes. OBJECTIVE: The aim was to investigate optic disc and retinal architecture in SCA2. […]
Non-apoptotic regulated cell death in Fuchs endothelial corneal dystrophy
Regen Ther. 2023 Nov 10;24:592-601. doi: 10.1016/j.reth.2023.11.001. eCollection 2023 Dec. ABSTRACT INTRODUCTION: Fuchs endothelial corneal dystrophy (FECD) is the leading cause of corneal blindness in developed countries. Corneal endothelial cells in FECD are susceptive to oxidative stress, leading to mitochondrial dysfunction and cell death. Oxidative stress causes many forms of cell death including parthanatos, which […]