Leber’s hereditary optic neuropathy
Rinsho Shinkeigaku. 2024 Apr 20. doi: 10.5692/clinicalneurol.cn-001924. Online ahead of print. ABSTRACT Leber’s hereditary optic atrophy (LHON) is a genetic optic neuropathy that is more prevalent in young males but can occur from childhood to old age. The primary cause is mitochondrial genetic mutations, which are associated with dysfunction of mitochondrial electron transport chain complex […]
Nanoceria-Mediated Cyclosporin A Delivery for Dry Eye Disease Management through Modulating Immune-Epithelial Crosstalk
ACS Nano. 2024 Apr 17. doi: 10.1021/acsnano.3c11514. Online ahead of print. ABSTRACT Dry eye disease (DED) affects a substantial worldwide population with increasing frequency. Current single-targeting DED management is severely hindered by the existence of an oxidative stress-inflammation vicious cycle and complicated intercellular crosstalk within the ocular microenvironment. Here, a nanozyme-based eye drop, namely nanoceria […]
Metabolic reprogramming of the retinal pigment epithelium by cytokines associated with age-related macular degeneration
Biosci Rep. 2024 Apr 24;44(4):BSR20231904. doi: 10.1042/BSR20231904. ABSTRACT The complex metabolic relationship between the retinal pigment epithelium (RPE) and photoreceptors is essential for maintaining retinal health. Recent evidence indicates the RPE acts as an adjacent lactate sink, suppressing glycolysis in the epithelium in order to maximize glycolysis in the photoreceptors. Dysregulated metabolism within the RPE […]
Retinoprotective Effect of SkQ1, Visomitin Eye Drops, Is Associated with Suppression of P38 MAPK and ERK1/2 Signaling Pathways Activity
Biochemistry (Mosc). 2024 Feb;89(2):201-211. doi: 10.1134/S0006297924020020. ABSTRACT Visomitin eye drops are the first and, so far, the only drug based on SkQ1 – the mitochondria-targeted antioxidant 10-(6′-plastoquinonyl) decyltriphenylphosphonium, developed in the laboratories of Moscow State University under the leadership of Academician V. P. Skulachev. SkQ1 is considered as a potential tool to combat the aging […]
Induction of Petite Colonies in Candida glabrate via Rose Bengal-Mediated Photodynamic Therapy
J Vis Exp. 2024 Mar 29;(205). doi: 10.3791/66549. ABSTRACT Facing a 40% mortality rate in candidemia patients, drug-resistant Candida and their petite mutants remain a major treatment challenge. Antimicrobial photodynamic therapy (aPDT) targets multiple fungal structures, unlike antibiotics/antifungals, potentially thwarting resistance. Traditional methods for inducing petite colonies rely on ethidium bromide or fluconazole, which can […]
A challenging differential diagnosis – Leber’s Hereditary Optic Neuropathy
Rom J Ophthalmol. 2024 Jan-Mar;68(1):65-71. doi: 10.22336/rjo.2024.13. ABSTRACT Leber’s hereditary optic neuropathy (LHON) is the most common maternally inherited disease linked to mitochondrial DNA (mtDNA). The patients present with subacute asymmetric bilateral vision loss. Approximately 95% of the LHON cases are caused by m.3460G>A (MTND1), m.11778G>A (MTND4), and m.14484T>C (MTND6) mutations. The hallmark of hereditary […]
Glutaminase deficiency in rod photoreceptors disrupts nonessential amino acid levels to activate the integrated stress response and induce rapid degeneration
bioRxiv [Preprint]. 2024 Mar 27:2024.03.26.582525. doi: 10.1101/2024.03.26.582525. ABSTRACT The bioenergetic demand of photoreceptors rivals that of cancer cells, and numerous metabolic similarities exist between these cells. Glutamine (Gln) anaplerosis via the tricarboxylic acid (TCA) cycle provides biosynthetic intermediates and is a hallmark of cancer metabolism. In this process, Gln is first converted to glutamate via […]
AIBP controls TLR4 inflammarafts and mitochondrial dysfunction in a mouse model of Alzheimer’s disease
bioRxiv [Preprint]. 2024 Mar 27:2024.02.16.580751. doi: 10.1101/2024.02.16.580751. ABSTRACT Microglia-driven neuroinflammation plays an important role in the development of Alzheimer’s disease (AD). Microglia activation is accompanied by the formation and chronic maintenance of TLR4 inflammarafts, defined as enlarged and cholesterol-rich lipid rafts serving as an assembly platform for TLR4 dimers and complexes of other inflammatory receptors. […]
Circumlimbal suture and laser burns: Comparison between two different chronic glaucoma models
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2024 Jan 28;49(1):84-94. doi: 10.11817/j.issn.1672-7347.2024.230112. ABSTRACT OBJECTIVES: Glaucoma is a multifactorial optic neuropathy with a high rate of irreversible visual loss, and its pathogenesis is complex and still unclear. Elevated intraocular pressure (IOP) is well recognized as the sole modifiable risk factor for the development of […]
A Pilot Analysis of Whole Transcriptome of Human Cryopreserved Sperm
Int J Mol Sci. 2024 Apr 8;25(7):4131. doi: 10.3390/ijms25074131. ABSTRACT Sperm cryopreservation is a procedure widely used to store gametes for later use, to preserve fertility in patients prior to gonadotoxic treatments or surgery, and for sperm donation programs. The purpose of the study was to assess the impact of cryopreservation on human sperm transcriptome. […]