In Vivo Imaging of the Schlemm’s Canal and the Response to Selective Laser Trabeculoplasty
Am J Ophthalmol. 2022 Feb;234:126-137. doi: 10.1016/j.ajo.2021.07.002. Epub 2021 Jul 18. ABSTRACT OBJECTIVE: To evaluate the presence of angle dysgenesis on ASOCT (anterior segment optical coherence tomography) (ADoA) as a predictive factor in determining outcomes of selective laser trabeculoplasty (SLT). DESIGN: A prospective clinical cohort study. SUBJECTS: Patients with juvenile-onset open-angle glaucoma (JOAG) without angle […]
Optical coherence tomography angiography in the multimodal assessment of the retinal posterior pole in autosomal dominant optic atrophy
Acta Ophthalmol. 2022 May;100(3):e798-e806. doi: 10.1111/aos.14972. Epub 2021 Jul 11. ABSTRACT PURPOSE: To assess retinal vascular involvement in patients with autosomal dominant optic atrophy (ADOA) genetically confirmed by the presence of the OPA1 (Optic Atrophy 1) gene mutation using a multimodal protocol of investigation of retinal posterior pole. METHODS: In this cross-sectional, case-control, observational study, […]
OPA1 Modulates Mitochondrial Ca2+ Uptake Through ER-Mitochondria Coupling
Front Cell Dev Biol. 2022 Jan 3;9:774108. doi: 10.3389/fcell.2021.774108. eCollection 2021. ABSTRACT Autosomal Dominant Optic Atrophy (ADOA), a disease that causes blindness and other neurological disorders, is linked to OPA1 mutations. OPA1, dependent on its GTPase and GED domains, governs inner mitochondrial membrane (IMM) fusion and cristae organization, which are central to oxidative metabolism. Mitochondrial […]
An aptamer-tethered DNA origami amplifier for sensitive and accurate imaging of intracellular microRNA
Nanoscale. 2022 Jan 27;14(4):1327-1332. doi: 10.1039/d1nr06399e. ABSTRACT Accurate detection and imaging of low-abundance microRNA (miRNA) in living cells are essential for the diagnosis and prognosis of diseases. Designing nanoprobes with resistance to enzyme degradation, effective cell-binding, and efficient signal amplification is crucial for in vivo imaging. In this study, we present an aptamer-tethered DNA origami […]
Mitochondrial Retinopathies
Int J Mol Sci. 2021 Dec 25;23(1):210. doi: 10.3390/ijms23010210. ABSTRACT The retina is an exquisite target for defects of oxidative phosphorylation (OXPHOS) associated with mitochondrial impairment. Retinal involvement occurs in two ways, retinal dystrophy (retinitis pigmentosa) and subacute or chronic optic atrophy, which are the most common clinical entities. Both can present as isolated or […]
Knee osteoarthritis accelerates amyloid beta deposition and neurodegeneration in a mouse model of Alzheimer’s disease
Mol Brain. 2023 Jan 2;16(1):1. doi: 10.1186/s13041-022-00986-9. ABSTRACT Knee osteoarthritis (OA) is characterized by knee cartilage degeneration and secondary bone hyperplasia, resulting in pain, stiffness, and gait disturbance. The relationship between knee OA and neurodegenerative diseases is still unclear. This study used an Alzheimer’s disease (AD) mouse model to observe whether osteoarthritis accelerates dementia progression […]
The effect of serifs and stroke contrast on low vision reading
Acta Psychol (Amst). 2023 Feb;232:103810. doi: 10.1016/j.actpsy.2022.103810. Epub 2022 Dec 21. ABSTRACT PURPOSE: Patients with low vision are generally recommended to use the same fonts as individuals with normal vision. However, we are yet to fully understand whether stroke width and serifs (small ornamentations at stroke endings) can increase readability. This study’s purpose was to […]
Expectation-Maximization-Based Simultaneous Localization and Mapping for Millimeter-Wave Communication Systems
Sensors (Basel). 2022 Sep 14;22(18):6941. doi: 10.3390/s22186941. ABSTRACT In this paper, we proposed a novel expectation-maximization-based simultaneous localization and mapping (SLAM) algorithm for millimeter-wave (mmW) communication systems. By fully exploiting the geometric relationship among the access point (AP) positions, the angle difference of arrival (ADOA) from the APs and the mobile terminal (MT) position, and […]
Reproducibility of retinal vessel density among three different OCTA devices in ADOA patients
Graefes Arch Clin Exp Ophthalmol. 2023 Jan;261(1):277-279. doi: 10.1007/s00417-022-05788-2. Epub 2022 Aug 8. NO ABSTRACT PMID:35939119 | DOI:10.1007/s00417-022-05788-2
Autosomal dominant optic atrophy caused by six novel pathogenic OPA1 variants and genotype-phenotype correlation analysis
BMC Ophthalmol. 2022 Jul 26;22(1):322. doi: 10.1186/s12886-022-02546-0. ABSTRACT PURPOSE: To describe the genetic and clinical features of nineteen patients from eleven unrelated Chinese pedigrees with OPA1-related autosomal dominant optic atrophy (ADOA) and define the phenotype-genotype correlations. METHODS: Detailed ophthalmic examinations were performed. Targeted next-generation sequencing (NGS) was conducted in the eleven probands using a custom […]