Letter to the Editor: Comment on Takai et al.’s “Age-Associated Differences in Optic Disc Findings of Leber’s Hereditary Optic Neuropathy”

Neuroophthalmology. 2026 Mar 9;50(3):292-293. doi: 10.1080/01658107.2026.2642121. eCollection 2026.

ABSTRACT

This letter comments on the study by Takai et al examining age-related differences in acute phase optic disc morphology in Leber hereditary optic neuropathy. We highlight methodological considerations in subjective fundus photograph assessment, and discuss additional factors such as refractive status and timing of presentation that may influence the presence of optic disc edema. These points may aid in refining phenotypic interpretation in future LHON studies.

PMID:42131159 | PMC:PMC13166217 | DOI:10.1080/01658107.2026.2642121