Petrified heart in a patient with Wolfram Syndrome

J Public Health Res. 2022 Jul 9;11(3):22799036221107063. doi: 10.1177/22799036221107063. eCollection 2022 Jul.


Myocardial calcification is a rare complication of severe systemic sepsis. The pathophysiological mechanisms underlying calcium accumulation in cardiomyocytes in generalized sepsis are complex and still under investigation. It is a serious and life-threatening condition, usually diagnosed by autopsy, rarely with imaging techniques. We describe the case of a 38-year-old woman with Wolfram Syndrome who developed diffuse myocardial calcification during an episode of generalized sepsis.

PMID:35911432 | PMC:PMC9335481 | DOI:10.1177/22799036221107063