Mitochondrial ferritin upregulation by deferiprone reduced neuronal ferroptosis and improved neurological deficits via NDRG1/Yap pathway in a neonatal rat model of germinal matrix hemorrhage
J Cereb Blood Flow Metab. 2024 Sep 24:271678X241252110. doi: 10.1177/0271678X241252110. Online ahead of print. ABSTRACT Ferroptosis contributes to brain injury after germinal matrix hemorrhage (GMH). Mitochondrial ferritin (FTMT), a novel mitochondrial outer membrane protein, reduces oxidative stress in neurodegenerative diseases. In vitro, Deferiprone has been shown to upregulate FTMT. However, the effects of FTMT upregulation […]
Overexpression of PRDM16 attenuates acute kidney injury progression: genetic and pharmacological approaches
MedComm (2020). 2024 Sep 21;5(10):e737. doi: 10.1002/mco2.737. eCollection 2024 Oct. ABSTRACT Acute kidney injury (AKI) presents as a condition marked by a sudden and rapid decrease in kidney function over a short timeframe, resulting from diverse causes. As a transcription factor, PR domain-containing 16 (PRDM16), has recently been implicated in brown fat biogenesis and heart […]
Mitochondrial metabolism blockade nanoadjuvant reversed immune-resistance microenvironment to sensitize albumin-bound paclitaxel-based chemo-immunotherapy
Acta Pharm Sin B. 2024 Sep;14(9):4087-4101. doi: 10.1016/j.apsb.2024.05.028. Epub 2024 Jun 3. ABSTRACT Currently, the efficacy of albumin-bound paclitaxel (PTX@Alb) is still limited due to the impaired PTX@Alb accumulation in tumors partly mediated by the dense collagen distribution. Meanwhile, acquired immune resistance always occurs due to the enhanced programmed cell death-ligand 1 (PD-L1) expression after […]
A novel frameshift variant in LAMP2 gene mimicking choroideremia carrier retinopathy
Ophthalmic Genet. 2024 Sep 19:1-8. doi: 10.1080/13816810.2024.2404148. Online ahead of print. ABSTRACT BACKGROUND: Danon disease is a rare, multisystemic X-linked dominant disorder caused by variants in the LAMP2 gene. It can be associated with retinal degeneration, but this is not well characterized. Here we describe a late presentation of a mild retinal phenotype, initially diagnosed […]
Zotarolimus alleviates post-trabeculectomy fibrosis via dual functions of anti-inflammation and regulating AMPK/mTOR axis
Int Immunopharmacol. 2024 Sep 19;142(Pt B):113176. doi: 10.1016/j.intimp.2024.113176. Online ahead of print. ABSTRACT OBJECTIVE: Postoperative scar formation is the primary cause of uncontrolled intraocular pressure following trabeculectomy failure. This study aimed to evaluate the efficacy of zotarolimus as an adjuvant anti-scarring agent in the experimental trabeculectomy. METHODS: We performed differential gene and Gene Ontology enrichment […]
Morphological multiparameter filtration and persistent homology in mitochondrial image analysis
PLoS One. 2024 Sep 20;19(9):e0310157. doi: 10.1371/journal.pone.0310157. eCollection 2024. ABSTRACT The complexity of branching and curvilinear morphology of a complete mitochondrial network within each cell is challenging to analyze and quantify. To address this challenge, we developed an image analysis technique using persistent homology with a multiparameter filtration framework, combining image processing techniques in mathematical […]
Hallmarks of aging in age-related macular degeneration and age-related neurological disorders: novel insights into common mechanisms and clinical relevance
Eye (Lond). 2024 Sep 17. doi: 10.1038/s41433-024-03341-5. Online ahead of print. ABSTRACT Age-related macular degeneration (AMD) and age-related neurological diseases (ANDs), such as Alzheimer’s and Parkinson’s Diseases, are increasingly prevalent conditions that significantly contribute to global morbidity, disability, and mortality. The retina, as an accessible part of the central nervous system (CNS), provides a unique […]
Timed topical dexamethasone eye drops improve mitochondrial function to prevent severe retinopathy of prematurity
Angiogenesis. 2024 Sep 17. doi: 10.1007/s10456-024-09948-2. Online ahead of print. ABSTRACT Pathological neovascularization in retinopathy of prematurity (ROP) can cause visual impairment in preterm infants. Current ROP treatments which are not preventative and only address late neovascular ROP, are costly and can lead to severe complications. We showed that topical 0.1% dexamethasone eye drops administered […]
Sex-dependent regulation of retinal pigment epithelium and retinal function by Pgc-1α
Front Cell Neurosci. 2024 Sep 2;18:1442079. doi: 10.3389/fncel.2024.1442079. eCollection 2024. ABSTRACT Age-related macular degeneration (AMD) is a major cause of blindness that affects people over 60. While aging is the prominent factor in AMD, studies have reported a higher prevalence of AMD in women compared to age-matched men. Higher levels of the innate immune response’s […]
Licochalcone A Ameliorates Aspergillus fumigatus Keratitis by Reducing Fungal Load and Activating the Nrf2/HO-1 Signaling Pathway
ACS Infect Dis. 2024 Sep 16. doi: 10.1021/acsinfecdis.4c00123. Online ahead of print. ABSTRACT Fungal keratitis (FK) is a blinding corneal infectious disease. The prognosis is frequently unfavorable due to fungal invasion and an excessive host inflammatory response. Licochalcone A (Lico A) exhibits a broad spectrum of pharmacological activities, encompassing antifungal, anti-inflammatory, antioxidation, and antitumor properties. […]