Rhein protects retinal Müller cells from high glucose-induced injury via activating the AMPK/Sirt1/PGC-1α pathway
J Recept Signal Transduct Res. 2023 Jun 18:1-10. doi: 10.1080/10799893.2023.2223319. Online ahead of print. ABSTRACT Oxidative stress, inflammation and apoptosis are important pathogenic factors of diabetic retinopathy (DR). In the current study, we aimed to evaluate the potential role of Rhein, a natural anthraquinone compound found in rhubarb, in high glucose (HG)-induced Müller cells (MIO-M1). […]
Titanium alloys with varying surface micro-area potential differences have antibacterial abilities and a favorable cellular response
Clin Oral Investig. 2023 Jun 17. doi: 10.1007/s00784-023-05115-x. Online ahead of print. ABSTRACT OBJECTIVES: Surface micro-area potential difference (MAPD) can achieve bacteriostatic performance independent of metal ion dissolution. To study the influence of MAPD on antibacterial properties and the cellular response, Ti-Ag alloys with different surface potentials were designed and prepared by changing the preparation […]
Evaluation of the role of Sigma 1 receptor and Cullin3 in retinal photoreceptor cells
Free Radic Biol Med. 2023 Jun 14:S0891-5849(23)00496-3. doi: 10.1016/j.freeradbiomed.2023.06.010. Online ahead of print. ABSTRACT Sigma 1 receptor (Sig1R), a pluripotent modulator of cell survival, is neuroprotective in models of retinal degeneration when activated by the high-affinity, high-specificity ligand (+)-pentazocine ((+)-PTZ). The molecular mechanisms of Sig1R-mediated retinal neuroprotection are under investigation. We previously reported that the […]
Targeting Ca2+-dependent pathways to promote corneal epithelial wound healing induced by CISD2 deficiency
Cell Signal. 2023 Jun 12:110755. doi: 10.1016/j.cellsig.2023.110755. Online ahead of print. ABSTRACT Chronic epithelial defects of the cornea, which are usually associated with severe dry eye disease, diabetes mellitus, chemical injuries or neurotrophic keratitis, as well as aging, are an unmet clinical need. CDGSH Iron Sulfur Domain 2 (CISD2) is the causative gene for Wolfram […]
Inhibiting HIF-1 signaling alleviates HTRA1-induced RPE senescence in retinal degeneration
Cell Commun Signal. 2023 Jun 14;21(1):134. doi: 10.1186/s12964-023-01138-9. ABSTRACT BACKGROUND: Age-related macular degeneration (AMD), characterized by the degeneration of retinal pigment epithelium (RPE) and photoreceptors, is the leading cause of irreversible vision impairment among the elderly. RPE senescence is an important contributor to AMD and has become a potential target for AMD therapy. HTRA1 is […]
(2E)-1-(2,4,6-trimethoxyphenyl)-3-(3-chlorophenyl)-2-propen-1-one, a Chalcone Derivative, Promotes Apoptosis by Suppressing RAS-ERK and AKT/FOXO3a Pathways in Hepatocellular Carcinoma Cells
Chem Biodivers. 2023 Jun 14:e202300050. doi: 10.1002/cbdv.202300050. Online ahead of print. ABSTRACT BACKGROUND: Liver cancer is an extremely common cancer with the highest mortality rate and poor prognosis. Owing to their low systemic toxicity and few side effects, natural compounds may provide better therapeutic effects for patients. (2E)-1-(2,4,6-trimethoxyphenyl)-3-(3-chlorophenyl)-2-propen-1-one (TMOCC), a chalcone derivative, exhibits cytotoxicity towards […]
Frontiers in Understanding the Pathological Mechanism of Diabetic Retinopathy
Med Sci Monit. 2023 Jun 12;29:e939658. doi: 10.12659/MSM.939658. ABSTRACT The retina is a light-sensitive membrane responsible for optical signal reception and concatenation with the optic nerve. Retinal damage causes blurred vision or visual dysfunction. Diabetic retinopathy (DR) is a common microvascular complication of diabetes mellitus (DM) that is induced by the interaction of multiple factors […]
Role of A-Kinase Anchoring Protein 1 in Retinal Ganglion Cells: Neurodegeneration and Neuroprotection
Cells. 2023 Jun 3;12(11):1539. doi: 10.3390/cells12111539. ABSTRACT A-Kinase anchoring protein 1 (AKAP1) is a multifunctional mitochondrial scaffold protein that regulates mitochondrial dynamics, bioenergetics, and calcium homeostasis by anchoring several proteins, including protein kinase A, to the outer mitochondrial membrane. Glaucoma is a complex, multifactorial disease characterized by a slow and progressive degeneration of the optic […]
Multimodal single-cell analysis of non-random heteroplasmy distribution in human retinal mitochondrial disease
JCI Insight. 2023 Jun 8:e165937. doi: 10.1172/jci.insight.165937. Online ahead of print. ABSTRACT Variants within the high copy number mitochondrial genome (mtDNA) can disrupt organelle function and lead to severe multi-system disease. The wide range of manifestations observed in mitochondrial disease patients results from varying fractions of abnormal mtDNA molecules in different cells and tissues, a […]
Akkermansia muciniphila-Nlrp3 is involved in the neuroprotection of phosphoglycerate mutase 5 deficiency in traumatic brain injury mice
Front Immunol. 2023 May 23;14:1172710. doi: 10.3389/fimmu.2023.1172710. eCollection 2023. ABSTRACT INTRODUCTION: Gut-microbiota-brain axis is a potential treatment to decrease the risk of chronic traumatic encephalopathy following traumatic brain injury (TBI). Phosphoglycerate mutase 5 (PGAM5), a mitochondrial serine/threonine protein phosphatase, resides in mitochondrial membrane and regulates mitochondrial homeostasis and metabolism. Mitochondria mediates intestinal barrier and gut […]