Astrocytes of the eye and optic nerve: heterogeneous populations with unique functions mediate axonal resilience and vulnerability to glaucoma
Front Ophthalmol (Lausanne). 2023;3:1217137. doi: 10.3389/fopht.2023.1217137. Epub 2023 Jul 21. ABSTRACT The role of glia, particularly astrocytes, in mediating the central nervous system’s response to injury and neurodegenerative disease is an increasingly well studied topic. These cells perform myriad support functions under physiological conditions but undergo behavioral changes – collectively referred to as ‘reactivity’ – […]
Near-Infrared BODIPY Photosensitizer for Modulating Mitochondrial Fusion Proteins and Inhibiting Choroidal Neovascularization
ACS Appl Mater Interfaces. 2023 Oct 9. doi: 10.1021/acsami.3c11053. Online ahead of print. ABSTRACT Photosensitizers have emerged as cytotoxic reactive oxygen species (ROS) activators in photodynamic therapy (PDT), which induced cell apoptosis. As the major contributors to ROS and oxidative stress, mitochondria play an important role in cell apoptosis. Although there are many reports about […]
cGAS-STING Pathway Activation and Systemic Anti-Tumor Immunity Induction via Photodynamic Nanoparticles with Potent Toxic Platinum DNA Intercalator Against Uveal Melanoma
Adv Sci (Weinh). 2023 Oct 9:e2302895. doi: 10.1002/advs.202302895. Online ahead of print. ABSTRACT The cGAS-STING pathway, as a vital innate immune signaling pathway, has attracted considerable attention in tumor immunotherapy research. However, STING agonists are generally incapable of targeting tumors, thus limiting their clinical applications. Here, a photodynamic polymer (P1) is designed to electrostatically couple […]
Use of 31 P magnetisation transfer magnetic resonance spectroscopy to measure ATP changes after 670 nm transcranial photobiomodulation in older adults
Aging Cell. 2023 Oct 6:e14005. doi: 10.1111/acel.14005. Online ahead of print. ABSTRACT Mitochondrial function declines with age, and many pathological processes in neurodegenerative diseases stem from this dysfunction when mitochondria fail to produce the necessary energy required. Photobiomodulation (PBM), long-wavelength light therapy, has been shown to rescue mitochondrial function in animal models and improve human […]
Early proteomic characteristics and changes in the optic nerve head, optic nerve, and retina in a rat model of ocular hypertension
Mol Cell Proteomics. 2023 Oct 2:100654. doi: 10.1016/j.mcpro.2023.100654. Online ahead of print. ABSTRACT The pathogenesis of glaucoma is still unknown. There are few studies on the dynamic change of tissue-specific and time-specific molecular pathophysiology caused by ocular hypertension (OHT). This study aimed to identify the early proteomic alterations in the retina, optic nerve head (ONH), […]
Repeated Low-Level Red-Light Therapy for Controlling Onset and Progression of Myopia-a Review
Int J Med Sci. 2023 Sep 4;20(10):1363-1376. doi: 10.7150/ijms.85746. eCollection 2023. ABSTRACT Repeated low-level red-light (RLRL), characterized by increased energy supply and cellular metabolism, thus enhancing metabolic repair processes, has gained persistent worldwide attention in recent years as a new novel scientific approach for therapeutic application in myopia. This therapeutic revolution led by RLRL therapy […]
CircRNA itchy E3 ubiquitin protein ligase improves mitochondrial dysfunction in sepsis-induced acute kidney injury by targeting microRNA-214-3p/ATP-binding cassette A1 axis
Ren Fail. 2023;45(2):2261552. doi: 10.1080/0886022X.2023.2261552. Epub 2023 Oct 2. ABSTRACT BACKGROUND: Circular RNAs (circRNAs) are promising biomarkers and therapeutic targets for acute kidney injury (AKI). In this study, we investigated the mechanism by which circRNA itchy E3 ubiquitin protein ligase (circ-ITCH) regulates sepsis-induced AKI. METHODS: A sepsis-induced AKI mouse model was created using LPS induction […]
5-aminolevulinate and CHIL3/CHI3L1 treatment amid ischemia aids liver metabolism and reduces ischemia-reperfusion injury
Theranostics. 2023 Aug 28;13(14):4802-4820. doi: 10.7150/thno.83163. eCollection 2023. ABSTRACT Rationale: Liver resection and transplantation surgeries are accompanied by hepatic ischemia-reperfusion (HIR) injury that hampers the subsequent liver recovery. Given that the liver is the main organ for metabolism and detoxification, ischemia-reperfusion in essence bestows metabolic stress upon the liver and disrupts local metabolic and immune […]
Genipin relieves diabetic retinopathy by down-regulation of advanced glycation end products via the mitochondrial metabolism related signaling pathway
World J Diabetes. 2023 Sep 15;14(9):1349-1368. doi: 10.4239/wjd.v14.i9.1349. ABSTRACT BACKGROUND: Glycation is an important step in aging and oxidative stress, which can lead to endothelial dysfunction and cause severe damage to the eyes or kidneys of diabetics. Inhibition of the formation of advanced glycation end products (AGEs) and their cell toxicity can be a useful […]
Shedding Light on Photobiomodulation Therapy for Age-Related Macular Degeneration: A Narrative Review
Ophthalmol Ther. 2023 Sep 28. doi: 10.1007/s40123-023-00812-y. Online ahead of print. ABSTRACT BACKGROUND: Photobiomodulation (PBM) relies on the pathophysiological mechanism whereby red to near-infrared light can target mitochondrial activity and promote ATP synthesis. Preclinical and clinical studies have shown promising results in treating intermediate age-related macular degeneration (AMD), since PBM can produce photochemical reactions in […]