The Role of HIF-1α in Retinopathy of Prematurity: A Review of Current Literature
J Clin Med. 2024 Jul 10;13(14):4034. doi: 10.3390/jcm13144034. ABSTRACT Hypoxia-inducible factor (HIF) plays a crucial role in regulating oxygen sensing and adaptation at the cellular level, overseeing cellular oxygen homeostasis, erythrocyte production, angiogenesis, and mitochondrial metabolism. The hypoxia-sensitive HIF-1α subunit facilitates tissue adaptation to hypoxic conditions, including the stimulation of proangiogenic factors. Retinopathy of prematurity […]
Genetic Analysis of 252 Index Cases with Inherited Retinal Diseases Using a Panel of 351 Retinal Genes
Genes (Basel). 2024 Jul 16;15(7):926. doi: 10.3390/genes15070926. ABSTRACT Inherited retinal diseases (IRDs) are extremely heterogeneous with at least 350 causative genes, complicating the process of genetic diagnosis. We analyzed samples of 252 index cases with IRDs using the Blueprint Genetics panel for “Retinal Dystrophy” that includes 351 genes. The cause of disease could be identified […]
Lactate/lactylation in ocular development and diseases
Trends Mol Med. 2024 Jul 24:S1471-4914(24)00187-4. doi: 10.1016/j.molmed.2024.07.001. Online ahead of print. ABSTRACT Lactylation, a post-translational modification (PTM) induced by lactate, has crucial roles in the regulation of transcription, DNA repair, and mitochondrial metabolism. Here, we discuss the role of lactate/lactylation signaling in regulating eye morphogenesis and retinal homeostasis, as well as various ophthalmic disorders, […]
OPTICAL COHERENCE TOMOGRAPHY FINDINGS IN PRESUMED VETERINARY ANTHELMINTIC DRUG-INDUCED RETINAL TOXICITY: A Glimpse into Underlying Mechanism
Retina. 2024 Aug 1;44(8):1456-1462. doi: 10.1097/IAE.0000000000004128. ABSTRACT PURPOSE: To report optical coherence tomography findings of presumed veterinary anthelmintic drugs (VADs)-induced retinal toxicity that may aid in understanding potential pathogenic mechanisms. METHODS: This is a retrospective observational case series analysis of patients with vision abnormalities following the accidental or intentional consumption of veterinary anthelmintic drugs. All […]
Mitochondrial transfer between BMSCs and Muller promotes mitochondrial fusion and suppresses gliosis in degenerative retina
iScience. 2024 Jun 20;27(7):110309. doi: 10.1016/j.isci.2024.110309. eCollection 2024 Jul 19. ABSTRACT Mitochondrial dysfunction and Müller cells gliosis are significant pathological characteristics of retinal degeneration (RD) and causing blinding. Stem cell therapy is a promising treatment for RD, the recently accepted therapeutic mechanism is cell fusion induced materials transfer. However, whether materials including mitochondrial transfer between […]
Evaluation of the Ocular Safety of Hollow Mesoporous Organosilica Nanoparticles with Different Tetrasulfur Bond Content
Int J Nanomedicine. 2024 Jul 16;19:7123-7136. doi: 10.2147/IJN.S464524. eCollection 2024. ABSTRACT BACKGROUND: Drug therapy for eye diseases has been limited by multiple protective mechanisms of the eye, which can be improved using well-designed drug delivery systems. Mesoporous silica nanoparticles (MSNs) had been used in many studies as carriers of therapeutic agents for ocular diseases treatment. […]
The landscape of clinical trials research in inherited ophthalmic disease
Ophthalmic Genet. 2024 Jul 24:1-8. doi: 10.1080/13816810.2024.2378013. Online ahead of print. ABSTRACT OBJECTIVE: To describe the current status of clinical trials of genetic eye diseases with identified molecular targets for future areas of research. METHOD: Data analysis of the clinical trials database on clinicaltrials.gov with keywords for eight common, genetically tractable inherited eye diseases and […]
Vitamin B5 metabolism is essential for vacuolar and mitochondrial functions and drug detoxification in fungi
Commun Biol. 2024 Jul 23;7(1):894. doi: 10.1038/s42003-024-06595-7. ABSTRACT Fungal infections, a leading cause of mortality among eukaryotic pathogens, pose a growing global health threat due to the rise of drug-resistant strains. New therapeutic strategies are urgently needed to combat this challenge. The PCA pathway for biosynthesis of Co-enzyme A (CoA) and Acetyl-CoA (AcCoA) from vitamin […]
Inhibition of mTOR differently modulates planar and subepithelial fibrogenesis in human conjunctival fibroblasts
Graefes Arch Clin Exp Ophthalmol. 2024 Jul 23. doi: 10.1007/s00417-024-06481-2. Online ahead of print. ABSTRACT PURPOSE: In the current investigation, the effects of the mTOR inhibitors, Rapa and Torin1 on the TGF-β2-induced conjunctival fibrogenesis were studied. STUDY DESIGN: Experimental research. METHODS: 2D and 3D cultures of HconF were subjected to the following analyses; (1) planar […]
The AKT2/SIRT5/TFEB pathway as a potential therapeutic target in non-neovascular AMD
Nat Commun. 2024 Jul 21;15(1):6150. doi: 10.1038/s41467-024-50500-z. ABSTRACT Non-neovascular or dry age-related macular degeneration (AMD) is a multi-factorial disease with degeneration of the aging retinal-pigmented epithelium (RPE). Lysosomes play a crucial role in RPE health via phagocytosis and autophagy, which are regulated by transcription factor EB/E3 (TFEB/E3). Here, we find that increased AKT2 inhibits PGC-1α […]