Mitofusin 2 inhibits high glucose-induced apoptosis of human lens epithelial cells via modulating mitochondrial function and autophagy
Folia Histochem Cytobiol. 2024 Jun 24. doi: 10.5603/fhc.98875. Online ahead of print. ABSTRACT INTRODUCTION: Diabetic cataract (DC) is a common ocular complication of diabetes. Mitofusin 2 (MFN2), a mitochondrial fusion protein, is involved in the pathogenesis of cataract and diabetic complications. However, its role and molecular mechanisms in DC remain unclear. MATERIALS AND METHODS: DC […]
Crucial Roles of RSAD2/viperin in Immunomodulation, Mitochondrial Metabolism and Autoimmune Diseases
Inflammation. 2024 Jun 23. doi: 10.1007/s10753-024-02076-5. Online ahead of print. ABSTRACT Autoimmune diseases are typically characterized by aberrant activation of immune system that leads to excessive inflammatory reactions and tissue damage. Nevertheless, precise targeted and efficient therapies are limited. Thus, studies into novel therapeutic targets for the management of autoimmune diseases are urgently needed. Radical […]
Sleep deprivation induces corneal endothelial dysfunction by downregulating Bmal1
BMC Ophthalmol. 2024 Jun 21;24(1):268. doi: 10.1186/s12886-024-03524-4. ABSTRACT BACKGROUND: Sleep deprivation (SD) is a common public health problem that contributes to various physiological disorders and increases the risk of ocular diseases. However, whether sleep loss can damage corneal endothelial function remains unclear. This study aimed to determine the effect and possible mechanism of SD on […]
Identification of the central role of RNA polymerase mitochondrial for angiogenesis
Cell Commun Signal. 2024 Jun 21;22(1):343. doi: 10.1186/s12964-024-01712-9. ABSTRACT Mitochondria are central to endothelial cell activation and angiogenesis, with the RNA polymerase mitochondrial (POLRMT) serving as a key protein in regulating mitochondrial transcription and oxidative phosphorylation. In our study, we examined the impact of POLRMT on angiogenesis and found that its silencing or knockout (KO) […]
NAD(+) Supplementation Improves Mitochondrial Functions and Normalizes Glaucomatous Trabecular Meshwork Features
Exp Cell Res. 2024 Jun 17:114137. doi: 10.1016/j.yexcr.2024.114137. Online ahead of print. ABSTRACT Glaucoma is characterized by pathological elevation of intraocular pressure (IOP) due to dysfunctional trabecular meshwork (TM), which is the primary cause of irreversible vision loss. There are currently no effective treatment strategies for glaucoma. Mitochondrial function plays a crucial role in regulating […]
Mitochondrial Retinopathy by MT-ATP6 Variant Revealed by Whole Genome Sequencing: A Case Report
Korean J Ophthalmol. 2024 Jun 19. doi: 10.3341/kjo.2024.0013. Online ahead of print. NO ABSTRACT PMID:38897591 | DOI:10.3341/kjo.2024.0013
Spinocerebellar ataxias: from pathogenesis to recent therapeutic advances
Front Neurosci. 2024 Jun 4;18:1422442. doi: 10.3389/fnins.2024.1422442. eCollection 2024. ABSTRACT Spinocerebellar ataxia is a phenotypically and genetically heterogeneous group of autosomal dominant-inherited degenerative disorders. The gene mutation spectrum includes dynamic expansions, point mutations, duplications, insertions, and deletions of varying lengths. Dynamic expansion is the most common form of mutation. Mutations often result in indistinguishable clinical […]
Manipulating mitochondrial pyruvate carrier function causes metabolic remodeling in corneal myofibroblasts that ameliorates fibrosis
Redox Biol. 2024 Jun 8;75:103235. doi: 10.1016/j.redox.2024.103235. Online ahead of print. ABSTRACT Myofibroblasts are key cellular effectors of corneal wound healing from trauma, surgery, or infection. However, their persistent deposition of disorganized extracellular matrix can also cause corneal fibrosis and visual impairment. Recent work showed that the PPARγ agonist Troglitazone can mitigate established corneal fibrosis, […]
Optic Nerve T2 Signal Intensity and Caliber Reflect Clinical Severity in Genetic Optic Atrophy
J Neuroophthalmol. 2024 Jun 17. doi: 10.1097/WNO.0000000000002191. Online ahead of print. ABSTRACT BACKGROUND: Genetic optic atrophies comprise phenotypically heterogenous disorders of mitochondrial function. We aimed to correlate quantitative neuroimaging findings of the optic nerves in these disorders with clinical measures. METHODS: From a retrospective database of 111 patients with bilateral optic atrophy referred for genetic […]
Mir-204-5p alleviates mitochondrial dysfunction by targeting IGFBP5 in diabetic cataract
Mol Biol Rep. 2024 Jun 14;51(1):755. doi: 10.1007/s11033-024-09701-4. ABSTRACT BACKGROUND: Cataract contributes to visual impairment worldwide, and diabetes mellitus accelerates the formation and progression of cataract. Here we found that the expression level of miR-204-5p was diminished in the lens epithelium with anterior lens capsule of cataract patients compared to normal donors, and decreased more […]