Cell Calcium. 2022 Jun;104:102572. doi: 10.1016/j.ceca.2022.102572. Epub 2022 Mar 24.
ABSTRACT
Wolfram syndrome is a rare genetic disorder characterized by endocrine dysfunction and progressive neurodegeneration. By targeting intracellular calcium dysregulations, a sigma-1 receptor agonist rescued neurological deficits in preclinical models of Wolfram syndrome.
PMID:35366518 | DOI:10.1016/j.ceca.2022.102572