Endoplasmic reticulum-mitochondria lockdown in Wolfram syndrome

Cell Calcium. 2024 Sep 12;124:102955. doi: 10.1016/j.ceca.2024.102955. Online ahead of print.

ABSTRACT

Wolfram syndrome (WS) is an incurable autosomal recessive disorder originally described as a mitochondriopathy. In a recent work, Liiv and colleagues found that an impaired endoplasmic reticulum (ER)-to-mitochondria calcium shuttling underlies mitochondrial dysfunction in WS models.

PMID:39278009 | DOI:10.1016/j.ceca.2024.102955