A case for the use of chemotherapy in hereditary mitochondrial optic neuropathies: Successful administration of cisplatin/etoposide in a male patient with testicular seminoma and Leber’s hereditary optic neuropathy

Clin Case Rep. 2024 Jul 8;12(7):e9045. doi: 10.1002/ccr3.9045. eCollection 2024 Jul.


We report on the successful use of chemotherapy for treatment of stage 2B testicular seminoma in a carrier of the Leber’s hereditary optic neuropathy 11778 mitochondrial mutation. Neurotoxic chemotherapy may not prompt disease conversion.

PMID:38979087 | PMC:PMC11228619 | DOI:10.1002/ccr3.9045